Chau, Wilkin Dr.
Dr. Wilkin Chau
Research Focus
My research focuses on method of analyzing functional MRI (fMRI) and
magnetoencephalographic (MEG) data. I am interested in all aspects of
data processing that affect the results of neuroimging studies. My study
areas include MRI spatial normalization, multivariate data analysis and
group statistics.
Spatial normalization of imging data is one of critical steps for group analysis and for multi-modality imaging studies. I have developed a procedure to normalize the MEG Synthetic Aperture Magnetometry (SAM) data based on the individual MRIs. This method allows researchers to perform group analysis, and is now being regularly used to analyze SAM data. The method was also successfully used to analyze the fMRI and MEG data in our somatosensory study.
Combining fMRI and MEG data allows researchers to study the temporal and spatial aspects of brain functioning. We have finished a study that uses both fMRI and MEG techniques to investigate the sensory responses. The concordance of the detected active brain regions from both imaging techniques was identified. The results of this study were selected to present orally in an international conference. A second study, using the two imaging techniques, is currently carrying out to examine the cognitive processing of visual attention.
Due to the different characteristics of fMRI and MEG techniques, there are many issues have to be resolved to integrating the measurements from both modalities. I will carry out some multi-modality imaging studies to investigate the relationship between the MEG magnetic fields and the fMRI BOLD signals. My ultimate goal is to develop a statistical analysis method to allow researchers to combining information from both MEG and fMRI data.
Spatial normalization of imging data is one of critical steps for group analysis and for multi-modality imaging studies. I have developed a procedure to normalize the MEG Synthetic Aperture Magnetometry (SAM) data based on the individual MRIs. This method allows researchers to perform group analysis, and is now being regularly used to analyze SAM data. The method was also successfully used to analyze the fMRI and MEG data in our somatosensory study.
Combining fMRI and MEG data allows researchers to study the temporal and spatial aspects of brain functioning. We have finished a study that uses both fMRI and MEG techniques to investigate the sensory responses. The concordance of the detected active brain regions from both imaging techniques was identified. The results of this study were selected to present orally in an international conference. A second study, using the two imaging techniques, is currently carrying out to examine the cognitive processing of visual attention.
Due to the different characteristics of fMRI and MEG techniques, there are many issues have to be resolved to integrating the measurements from both modalities. I will carry out some multi-modality imaging studies to investigate the relationship between the MEG magnetic fields and the fMRI BOLD signals. My ultimate goal is to develop a statistical analysis method to allow researchers to combining information from both MEG and fMRI data.
Publications
| Title | Source (Journal/Book/Conference) | Authors/Presenters | Published On | Type |
|---|---|---|---|---|
| Higher complexity predicts lower BOLD activity in default mode regions after traumatic brain injury | SOCIETY FOR NEUROSCIENCE ABSTRACTS | Raja AC, Kovacevic N, Tisserand D, Chau W, McIntosh AR, | 1256011200 | Abstract |
| Music training leads to the development of timbre-specific gamma band activity | Neuroimage | Shahin AJ, Roberts LE, Chau W, Trainor LJ, Miller LM | 1203570000 | Journal Article |
| Somatosensory processing in focal hand dystonia | Festival of international conferences on caregiving, disability, aging and technology | Nelson A, Chau W, Ross B, Bardouille T, Chen R | 1181966400 | Abstract |
| Rhythmic brain activities related to singing in humans | NeuroImage | Gunji A, Ishii R, Chau W, Kakigi R, Pantev C, | 1167627600 | Journal Article |
| Traumatic brain injury patients show increased gamma activity during visual feature-matching | International Congress Series | Chau W, Ross B, Tisserand D, Restagno A, Picton TW, Stuss D, Levine B | 1167627600 | Journal Article |
| Cortical oscillations related to processing congruent and incongruent grapheme-phoneme pairs | Neuroscience Letters | Herdman AT, Fujioka T, Chau W, Ross B, Pantev C, Picton TW | 1147665600 | Journal Article |
| Modulation of effective connectivity by cognitive demand in phonological verbal fluency | Neuroimage | Fu CH, McIntosh AR, Kim J, Chau W, Bullmore ET, Williams SC, Honey GD, McGuire PK | 1138770000 | Journal Article |
| Traumatic brain injury patients show increased gamma activity during visual feature-matching | New Frontiers in Biomagnetism: Proceedings of the 15th International Conference on Biomagnetism | Chau W, Ross B, Tisserand D, Restagno A, Picton T, Stuss DT, Levine B | 1136091600 | Presentation |
| Left thalamo-cortical network implicated in successful speech separation and identification | NeuroImage | Alain C, Reinke K, McDonald KL, Chau W, Tam F, Pacurar A, Graham S | 1117598400 | Journal Article |
| The Talairach coordinate of a point in the MNI space: How to interpret it | NeuroImage | Chau W, McIntosh AR | 1112331600 | Journal Article |
| Effect of bilingualism on cognitive control in the Simon Task: Evidence from MEG | NeuroImage | Bialystok E, Craik FIM, Grady CL, Chau W, Ishii R, Gunji A, Pantev C | 1104555600 | Journal Article |
| Cortical processing of esophageal sensation is related to the representation of swallowing | Neuroreport | Dziewas R, Soros P, Ishii R, Chau W, Henningsen H, Ringelstein EB, Knecht S, Pantev C | 1104555600 | Journal Article |
| Combining Multiple Sessions MEG Data | Organization for Human Brain Mapping | Chau W, Fujioka T, Ross B | 1104555600 | Presentation |
| Cortical oscillations modulated by congruent and incongruent audiovisual stimuli | Neurology and Clinical Neurophysiology | Herdman AT, Fujioka T, Chau W, Ross B, Pantev C, Picton TW | 1101790800 | Journal Article |
| Improving permutation test power for group analysis spatially filtered MEG data | Neuroimage | Chau W, McIntosh AR, Robinson SE, Schulz M, Pantev C | 1099285200 | Journal Article |
| Improving permutation test power for group analysis of spatially filtered MEG data. | NeuroImage | Chau W, McIntosh AR, Robinson SE, Schulz M, Pantev C | 1099285200 | Journal Article |
| Spatiotemporal analysis of event-related fMRI data using partial least squares | NeuroImage | McIntosh AR, Chau W, Protzner AB | 1096603200 | Journal Article |
| Cortical representation of event-related desynchronization during singing in humans | INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY | Gunji A, Ishii R, Okamoto H, Chau W, Kakigi R, Pantev C | 1094011200 | Abstract |
| Improving Power of Permutation Test Using Unbiased Maximal Null Distribution for fMRI Data Analysis | ISMRM Twelfth Scientific Meeting & Exhibition | Chau W, McIntosh AR | 1084593600 | Presentation |
| An integrative MEG-fMRI study of the primary somatosensory cortex using cross-modal correspondence analysis | Neuroimage | Schulz M, Chau W, Graham SJ, McIntosh AR, Ross B, Ishii R, Pantev C | 1083384000 | Journal Article |
| Localization of transient and steady-state auditory evoked responses using synthetic aperture magnetometry | BRAIN AND COGNITION | Herdman AT, Wollbrink A, Chau W, Ishii R, Pantev C | 1078117200 | Abstract |
| Multi-modality imaging data analysis with partial least squares | BRAIN AND COGNITION | Chau W, Habib R, McIntosh AR | 1078117200 | Abstract |
| MEG Analysis of "Theory of Mind" in Emotional Vignettes Comprehension | Neurology and Clinical Neurophysiology | Ishii R, Gojmerac C, Stuss DT, Gallup GG, Alexander MP, Chau W, Pantev C | 1072933200 | Journal Article |
| Detection of power changes between conditions using split-half resampling of Synthetic Aperture Magnetometry data | Neurology and Clinical Neurophysiology | Chau W, Herdman AT, Picton TW | 1072933200 | Journal Article |
| The generator of MEG sleep spindle | BRAIN AND COGNITION | Ishii R, Dziewas R, Chau W, Soros P, Okamoto H, Gunji A, Pantev C | 1072933200 | Abstract |
| A spatiotemporal approach to cortical mapping using synthetic aperture magnetometry | BRAIN AND COGNITION | Bardouille T, Herdman AT, Chau W, Pantev C | 1072933200 | Abstract |
| Cortical oscillations modulated by congruent and incongruent audiovisual stimuli | 14th International Conference on Biomagnetism | Herdman AT, Fujioka T, Chau W, Ross B, Pantev C, Picton TW | 1072933200 | Presentation |
| Detection of Power Changes Between Conditions using Split-Half Resampling for Synthetic Aperture Magnetometry Data | BIOMAG 2004: 14th International Conference on Biomagnetism | Chau W, Herdman AT, Picton T | 1072933200 | Presentation |
| Determination of activation areas in the human auditory cortex by means of synthetic aperture magnetometry | NeuroImage | Herdman AT, Wollbrink A, Chau W, Ishii R, Ross B, Pantev C, Ross R | 1064980800 | Journal Article |
| Neuroimaging evidence for cortical involvement in the preparation and in the act of swallowing | NeuroImage | Dziewas R, Soros P, Ishii R, Chau W, Henningsen H, Ringelstein EB, Knecht S, Pantev C | 1062388800 | Journal Article |
| Cross-Modal Correspondence Analysis for MEG and fMRI data | ISMRM Eleventh Scientific Meeting & Exhibition | Chau W, Schulz M, Graham S, Pantev C, McIntosh AR | 1057809600 | Presentation |
| Cross modal correspondance analysis for MEG and fMRI data | ISMRM Eleventh Scientific Meeting & Exhibition | Chau W, Schulz M, Graham SJ, Pantev C, McIntosh AR | 1057809600 | Presentation |
| Current source density distribution of sleep spindles in humans as found by synthetic aperture Magnetometry | Neuroscience Letters | Ishii R, Dziewas R, Chau W, Okamoto H, Gunji A, Pantev C, Soros P, Soro P | 1041397200 | Journal Article |
| Tomographic visualization of generators of posterior alpha rhythm and Rolandic Mu rhythm analyzed by SAM, SPM99 and permutation (in Japanese) | Journal of Japanese Biomagnetic Conference | Ishii R, Chau W, Gunji A, Kazuhiro S, Takeda M, Pantev C | 1041397200 | Journal Article |
| SAM Analysis on Oscillatory MEG Activity related to Auditory P300 | The 4th MEG Neuroimaging Conference, Okazaki Conference Center | Ishii R, Ukai S, Shinosaki K, Gunji A, Yamamoto M, Kawaguchi S, Ogawa A, Chau W, Pantev C, Takeda M | 1041397200 | Presentation |
| Spatiotemporal Maps of Transient Auditory Evoked Fields | Sixth IBRO World Congress of Neuroscience | Herdman AT, Bardouille T, Chau W, Ross R, Pantev C | 1041397200 | Presentation |
| A Magnetoencephalographic Study of Cortical Responses to Incongruent Grapheme-Phoneme Stimuli: When and Where in the Brain? Auditory System and Processing of Complex Acoustic Signals | A Satellite Symposium to The 6th IBRO World Congress of Neuroscience | Herdman AT, Bardouille T, Chau W, Ross R, Pantev C | 1041397200 | Presentation |
| An empirical comparison of SPM preprocessing parameters to the analysis of fMRI data | NeuroImage | Della-Maggiore V, Chau W, Peres-Neto PR, McIntosh AR | 1030852800 | Journal Article |
| Increased anterior cingulate activity with task difficulty related to modulation of its regional effective connectivity | NEUROIMAGE | CHY F, McGuire PK, Kim J, Bullmore ET, Honey G, Chau W, McIntosh AR | 1022990400 | Abstract |
| Event-related fMRI Data Analysis Using Partial Least Squares Method | ISMRM Tenth Scientific Meeting & Exhibition | Chau W, Giesbrecht B, Mangun GR, McIntosh AR | 1021694400 | Presentation |
| Group Analysis for the Synthetic Aperture Magnetometry (SAM) Data | Proceedings of the 13th International Conference on Biomagnetism, VDE Verlag | Chau W, Schulz M, Ishii R, Ross B, McIntosh AR, Pantev C | 1009861200 | Presentation |
| Comparative MEG-fMRI Study of the Human Somatosensory Cortex | Proceedings of the 13th International Conference on Biomagnetism | Schulz M, Chau W, Graham S, Ishii R, Ross B, Pantev C | 1009861200 | Presentation |
| The Interplay Between Motion Correction and Slice Timing Correction in fMRI Data Processing | ISMRM Ninth Scientific Meeting & Exhibition | Chau W, Graham SJ, McIntosh AR | 987825600 | Presentation |
| The Interplay between Motion Correction and Slice Timing Correction in fMRI Data Processing | ISMRM Ninth Scientific Meeting & Exhibition | Chau W, Graham SJ, McIntosh AR | 987825600 | Presentation |
Education
- 2001: Post-doctoral Training, NeuroImaging, Rotman Research Institute, Toronto, ON, Canada
- 1999: PhD, Computer Science, University of Waterloo, Waterloo, ON, Canada
- 1991: MSc, Computer Science, University of Regina, Regina, SK, Canada
- 1988: BSc (Hon), Computer Science, University of Regina, Regina, SK, Canada
Academic Appointments
- 2003–2005: Scientist , Rotman Research Institute, Baycrest Centre, Toronto, ON, Canada
- 2002–2003: Research Associate, Rotman Research Institute, Baycrest Centre, Toronto, ON, Canada
Professional Affiliations
- 2004–2005:
- 2002–2004: International Society for Magnetic Resonance in Medicine
Distinctions and Awards
- 1996: ITRC/ICR Ph.D. Graduate Scholarship, University of Waterloo
- 1994: Mathematics Faculty Graduate Scholarship, University of Waterloo
- 1991: Graduate Scholarship, Province of Saskatchewan
- 1988: General Proficiency Scholarship, University of Regina
- 1988: Dean's List, University of Regina
- 1986: SaskCOMP Scholarship, University of Regina
Curriculum Vitae
Contact
Rotman Research InstituteBaycrest
3560 Bathurst Street, 1006
Toronto, Ontario
Canada M6A 2E1 Phone: 416 785-2500 x2487 Email: wchau
rotman-baycrest.on.ca Fax: 416 785-2862
Baycrest is an academic health sciences centre fully affiliated with the University of Toronto
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