Lynne Williams

Dr. Lynne Williams, PhD

fMRI Specialist and Program Manager Centre for Brain Fitness, Rotman Research Institute, Baycrest

Research Focus

My research interests are in the cognitive neuroscience of language development over the lifespan and in developing statistical techniques to analyse multivariate data as found, for example, in functional brain imaging (including fMRI, MEG, fNIRS and EEG) and discourse analysis (e.g., multi-block discriminant correspondence analysis, partial least squares analysis).  My most recent work is concerned with pattern classifiers in brain imaging, changes and variability in brain activation and behaviour in ageing and dementia, and the development of semantic and conceptual representations across the lifespan.

Publications

Title Source (Journal/Book/Conference) Authors/Presenters Published On Type
Learning, neural plasticity and sensitive periods: Implications for language acquisition, music training, and transfer across the lifespan Frontiers in Systems Neuroscience White E, Hutka S, Williams L, Moreno S 1386565200 Journal Article
Multiple factor analysis: principal component analysis for multi-table and multi-block data sets Wiley Interdisciplinary Reviews Computational Statistics Abdi H, Williams LJ, Valentin D 1357016400 Journal Article
The Survey of Autobiographical Memory (SAM): A novel measure of trait mnemonics in everyday life. Cortex Palombo D, Williams L, Abdi H, Levine B 1347422400 Journal Article
Partial least squares methods: Partial least squares correlation and partial least square regression Methods in Molecular Biology: Computational Toxicology Abdi H, Williams LJ 1342411200 Book Chapter
Effect of Age on Variability in the Production of Text-Based Global Inferences PLoS ONE Williams LJ, Dunlop JP, Abdi H 1338609600 Journal Article
Analysis of regional cerebral blood flow data to discriminate among Alzheimer's disease, fronto-temporal dementia, and elderly controls: A multi-block barycentric discriminant analysis (MUBADA) methodology Journal of Alzheimer Disease Abdi H, Williams LJ, Beaton D, Posamentier M, Harris TS, Krishnan A, Devous MD 1338523200 Journal Article
Multiple Subject Barycentric Discriminant Analysis (MUSUBADA): How to assign scans to categories without using spatial normalization Computational and Mathematical Methods in Medicine Abdi H, Williams LJ, Connolly AC, Gobbini MI, Dunlop JP, Haxby JV 1334030400 Journal Article
STATIS and DISTATIS: optimum multitable principal component analysis and three way metric multidimensional scaling Wiley Interdisciplinary Reviews: Computational Statistics Abdi H, Williams LJ, Valentin D, Bennani-Dosse M 1329368400 Journal Article
Neural circuitry of emotional processing in late-life depression Human Brain Mapping Mah L, Williams LJ, Leung R, Freel S, Pollock B 1302235200 Abstract
Neural substrates of emotional processing in late-life depression. Biological Psychiatry Mah L, Williams LJ, Leung R, Freel S, Pollock B 1302235200 Abstract
Partial Least Squares (PLS) methods for neuroimaging: A tutorial and review NeuroImage Krishnan A, Williams LJ, McIntosh AR, Abdi H 1296277200 Journal Article
Effects of Animal Assisted Therapy on Conversation in a Married Couple with Alzheimer’s Disease International Ethological Conference Orange JB, Robertson C, Williams LJ 1288324800 Presentation
Group differences in response patterns on a measure of conversational skills in dementia International Association of Gerontology and Geriatrics Orange JB, Williams LJ, Lubinski R, Purves B, Johnson A, Small J 1288324800 Presentation
How to compute reliability estimates and display confidence and tolerance intervals for pattern classifiers using the Bootstrap and 3-way multidimensional scaling (DISTATIS) NeuroImage Abdi H, Dunlop JP, Williams LJ 1287720000 Journal Article
Coefficients of correlation, alienation, and determination Encyclopedia of Research Design Abdi H, Williams LJ 1287720000 Book Chapter
Contrast analysis Encyclopedia of Research Design Abdi H, Williams LJ 1287720000 Book Chapter
Correspondence analysis Encyclopedia of Research Design Abdi H, Williams LJ 1287720000 Book Chapter
Fisher's least significance difference (LSD) test Encyclopedia of Research Design Williams LJ, Abdi H 1287720000 Book Chapter
Honestly significant difference (HSD) test Encyclopedia of Research Design Abdi H, Williams LJ 1287720000 Book Chapter
Jackknife Encyclopedia of Research Design Abdi H, Williams LJ 1287720000 Book Chapter
Matrix algebra Encyclopedia of Research Design Abdi H, Williams LJ 1287720000 Book Chapter
Newman-Keuls and Tukey test Encyclopedia of Research Design Abdi H, Williams LJ 1287720000 Book Chapter
Normalizing data Encyclopedia of Research Design Abdi H, Williams LJ 1287720000 Book Chapter
Post-hoc comparisons Encyclopedia of Research Design Williams LJ, Abdi H 1287720000 Book Chapter
A tutorial on multiblock discriminant correspondence analysis (MUDICA): A new method for analyzing discourse data from clinical populations Journal of Speech, Language, and Hearing Research Williams LJ, Abdi H, French R, Orange JB 1285905600 Journal Article
Barycentric discriminant analysis (BADIA) Encyclopedia of Research Design Abdi H, Williams LJ 1280635200 Book Chapter
Principal component analysis Wiley Interdisciplinary Reviews: Computational Statistics Abdi H, Williams LJ 1277956800 Journal Article
Barycentric Discriminant Analysis (BDA): a new pattern recognition classifier that identifies voxels and regions of interest relevant for classification of functional brain imaging data Human Brain Mapping Devous MD, Abdi H, Williams LJ, Posamentier M, Harris TS 1245297600 Abstract
Holistic assessment of narrative quality: A social validation study Aphasiology Olness GS, Ulatowska HK, Carpenter C, Williams-Hubbard LJ, Dykes JC 1116734400 Journal Article
Coherence of narratives in aphasia Brain and Language Ulatowska HK, Olness GS, Williams LJ 1098417600 Journal Article
Evaluation of the effectiveness of two clinical training procedures to elicit yes/no responses from patients with a severe acquired brain injury: A randomized single-subject design Brain Injury Barreca S, Velikonja D, Brown L, Williams LJ, Davis L, Sigouin C 1066795200 Journal Article

Education

Academic Appointments

  • 2012–Present: fMRI Specialist and Program Manager, Centre for Brain Fitness, Rotman Research Institute, Baycrest

Reviewership

Membership

    Other

    • NeuroImage

    Research Projects

    External

    • 2010–2011: Early Researcher Award
      Supervisor: Cheryl Grady
      Collaborators: Hervé Abdi, JB Orange, Micheal Devous Sr.
      Institutions: Baycrest Centre for Geriatric Care

      Sponsors: Ontario Research Coalition of Research Institutes/Centres on Aging (ORC), $2,000 (CAD)

      Fellowship
    • 1998–2000:
      Supervisor: J.B. Orange
      Institutions: University of Western Ontario

      Sponsors: Ontario Neurotrauma Foundation, $20,000 (CAD)

      Fellowship

    Curriculum Vitae

    Contact

    3560 Bathurst Street
    Toronto, Ontario M6A 2E1
    Canada Phone: 416-785-2500 ext. 3149 Email: lwilliams@research.baycrest.org