Kie Honjo

Dr. Kie Honjo

Post-Doctoral Fellow Kunin-Lunenfeld Applied Research Unit (KLARU), Baycrest

Research Focus

My research is mainly focusing on detection of beta-amyloid with the tracer [11C]SB-13 positron emission tomography (PET). Applying this tracer for the brain of patients with Alzheimer’s disease, it could be useful for monitoring the relationship between progression of symptoms and progression of neuropathology, and also for monitoring the effect of the amyloid-reducing treatments. Applying this tracer for the brain of patients at the risk for progressing to Alzheimer’s disease will be another focus of the research.

Publications

Title Source (Journal/Book/Conference) Authors/Presenters Published On Type
Variability in stroke motor outcome is explained by structural and functional integrity of the motor system. Nat Sci Rep Lam TK, Dawson DR, Honjo K, Ross B, Binns MA, Stuss DT, Black SE, Chen JJ, Levine, BT, Fujioka, T, Chen, JL 1529035200 Journal Article
Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke J Neurol Sci Lam TK, Dawson DR, Honjo K, Ross B, Binns MA, Stuss DT, Black SE, Chen JJ, Levine BT, Fujioka T, Chen JL 1515992400 Journal Article
Progression of limb apraxia in corticobasal syndrome: neuropychological and functional neuroimaging report of a case series. Neurocase Stamenova V, Roy EA, Szilagyi G, Honjo K, Black SE, Masellis M 1420088400 Journal Article
Congenital absence of the mammillary bodies: a novel finding in a well-studied case of developmental amnesia. Neuropsychologia Rosenbaum RS, Gao F, Honjo K, Raybaud C, Olsen RK, Palombo DJ, Levine B, Black SE 1388552400 Journal Article
An [11C]SB-13 PET study correlating neuropsychiatric symptoms in Alzheimer’s disease with regional beta-amyloid burden Psychiatry Research: Neuroimaging Kaye ED, Honjo K, Petrovic-Poljak A, Reekum R, Streiner DL, Wilson AA, Black SE, Freedman M, Rusjan P, Houle S, Chow TW, Verhoeff NPLG 1325307600 Journal Article
Amyloid imaging with [11C]SB-13 PET: a test-retest reliability study 36th Annual Harvery Stancer Research Day Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black S 1303963200 Presentation
Amyloid Imaging with [11C]SB-13 PET: A Test-Retest Reliability Study Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black S 1278734400 Presentation
Amyloid imaging with [11C]SB-13 PET: A test-retest reliability study ALZHEIMER'S & DEMENTIA Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black SE 1278734400 Abstract
Correlating neuropsychiatric symptoms with cerebral beta-amyloid load in mild Alzheimer's disease using [11C]SB-13 PET Kaye ED, Honjo K, Petrovic-Poljak A, van Reekum R, Streiner DL, Wilson A, Black SE, Freedman M, Rusjan P, Houle S, Verhoeff NPLG 1276747200 Presentation
Commentary on the letter for Alzheimer’s disease and infection: Do infectious agents contribute to progression of Alzheimer’s disease? Alzheimer’s & Dementia Honjo K, Van Reekum R, Verhoeff NPLG 1262322000 Journal Article
Correlating neuropsychiatric symptoms with regional Beta-Amyloid load in the Alzheimer’s Disease brain using [11C]SB-13 PET Kaye E, Honjo K, Petrovic-Poljak A, van Reekum R, Streiner D, Wilson A, Black S, Freedman M, Rusjan P, Houle S, Verhoeff P 1258088400 Presentation
Does Beta-Amyloid correlate with neuropsychiatric symptoms in mild Alzheimer’s Disease? Kaye E, Honjo K, Petrovic-Poljak A, van Reekum R, Streiner D, Wilson A, Black S, Freedman M, Rusjan P, Houle S, Verhoeff P 1258088400 Presentation
Cognitive correlations of stroke, white matter disease and brain atrophy after stroke: preliminary validation of NINDS-VCI Harmonization Criteria CANADIAN JOURNAL OF GERIATRICS Honjo K, Gao FQ, Stebbins GT, Lobaugh NJ, Scott CJM, Zhou XJ, Graham SJ, Rizkalla MN, Geary E, Ganda A, Stuss DT, Nyenhuis DL, Black SE 1254369600 Abstract
Amyloid Imaging with [11C]SB-13 PET: A Test-Retest Reliability Study CANADIAN JOURNAL OF GERIATRICS Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black S 1254369600 Abstract
Cognitve correlations of stroke, white matter disease and brain atrophy after stroke: preliminary validation of NINDS-VCI Harmonization criteria Black SE, Honjo K, Gao FQ, Stebbins GT, Lobaugh NJ, Scott CJM, Zhou XJ, Graham SJ, Nyenhuis DL 1247284800 Presentation
MRI validation of the NINDS-CSN proposed neuropsychological assessment battery for Vascular Cognitive Impairment Murphy C, Zhou J, Graham S, Lobaugh N, Rangwala N, Scott CJM, Gao F, Black S, Nyenhuis D, Stuss D, Ganda A, Rizkalla M, Pedelty L, Geary E, Honjo K, Stebbins GT 1247284800 Presentation
Discriminant validity for the proposed NINDS-CSN harmonization vascular cognitive impairment neuropsychological assessment protocols Nyenhuis D, Geary E, Rizkalla M, Ganda A, Honjo K, Pedelty L, Black S, Stuss D, Stebbins GT 1247284800 Presentation
Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease? Alzheimer’s & Dementia Honjo K, Van Reekum R, Verhoeff NPLG 1246420800 Journal Article
Amyloid imaging with [11C]SB-13 PET: a test-retest reliability study 35th Annual Harvery Stancer Research Day Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black S 1245902400 Presentation
Correlating neuropsychiatric symptoms with regional beta-amyloid load in the Alzheimer’s disease brain using [11C]SB-13 PET UNIVERSITY OF TORONTO DEPARTMENT OF PSYCHIATRY Kaye ED, Honjo K, Petrovic-Poljak A, Van Reekum R, Streiner D, Wilson AA, Black SE, Freedman M, Rusjan P, Houle S, Verhoeff NPLG 1245902400 Abstract
Correlating neuropsychiatric symptoms with regional beta-amyloid load in the Alzheimer’s disease brain using [11C]SB-13 PET CANADIAN JOURNAL OF GERIATRICS Kaye ED, Honjo K, Petrovic-Poljak A, Van Reekum R, Streiner D, Wilson AA, Black SE, Freedman M, Rusjan P, Houle S, Verhoeff NPLG 1240632000 Abstract
Comparison of manual and semi-automated delineation of regions of interest for radioligand PET imaging analysis BMC Nuclear Medicine Chow TW, Takeshita S, Honjo K, Pataky CE, St Jacques PL, Kusano ML, Caldwell CB, Ramirez J, Black S, Verhoeff NPLG 1167627600 Journal Article
Alzheimer's disease and cerebrovascular disease - links with amyloid beta protein Kunin-Lunenfeld Applied Research Unit Rounds Honjo K, Verhoeff NPLG 1136091600 Presentation
What relevant aspects of the beta-amyloid cascade do we image with [11C]SB-13 PET? Neuroscience Rounds at at Sunnybrook and Women's College Health Sciences Centre Verhoeff NPLG, Honjo K 1136091600 Presentation
Alzheimer's disease and cerebrovascular disease - links with amyloid beta protein Department of Behavioural Neurology Rounds, Baycrest Centre for Geriatric Care Honjo K, Verhoeff NPLG 1136091600 Presentation
Alzheimer disease (AD) and cerebrovascular disease (CVD) - links with amyloid beta protein Grand Rounds at the Department of Geriatric Psychiatry Honjo K, Verhoeff NPLG 1136091600 Presentation
What relevant aspects of the beta-amyloid cascade do we image with [11C]SB-13 PET? PET Centre Seminars at the Centre for Addiction and Mental Health, Clarke Site Honjo K, Verhoeff NPLG 1104555600 Presentation
Endoscopy is one of the valuable diagnostic methods forprimary aorto-enteric fistula Digestive Endoscopy Honjo K, Okada H, Sumii K, Kobatake T, Fujioka S, Kumagai I, Takeda S, Teraoka A 1072933200 Journal Article
Quantitative assessment of cerebral blood flow in genetically confirmed spinocerebellar ataxia Type 6 Archives of Neurology Honjo K, Ohshita T, Kawakami H, Naka H, Imon Y, Maruyama H, Mimori Y, Matsumoto M 1072933200 Journal Article
Japan Statin Treatment Against Recurrent Stroke (J-STARS) Clinical Research Fellow Honjo K 1072933200 Presentation
Progressive supranuclear palsy (in Japanese) JOHNS Mimori Y, Ohshita T, Honjo K, Imon Y 1041397200 Journal Article
Near infrared rays spectroscopy (NIRS) assessment of nicotinic effect on cognitive function in patients with dementia 2004 Annual Report Mimori Y, Ohshita T, Inoue K, Honjo K, Matsumoto M 1041397200 Presentation
Magnetization transfer measurements of brain structuresin patients with multiple system atrophy NeuroImage Naka H, Imon Y, Ohshita T, Honjo K, Kitamura T, Miyachi T, Katayama S, Mimori Y, Nakamura S 1009861200 Journal Article
Magnetization transfer measurements of cerebral white matter in patients with myotonic dystrophy Journal of the Neurological Sciences Naka H, Imon Y, Ohshita T, Honjo K, Kitamura T, Mimori Y, Nakamura S 1009861200 Journal Article
A case of late onset mitochondrial neuromyopathy Nippon Ronen Igakkai Zasshi Honjo K, Mimori Y, Morino H, Katayama S, Nakamura S 1009861200 Journal Article
Immunochemical staining of glial cytoplasmic inclusions and clinicopathological assessment using magnetization transfer imaging in multiple system atrophy 2002 Annual Group Conference: Welfare Measures for People with Neurodegenerative Disorders Nakamura S, Katayama S, Naka H, Ohshita T, Imon Y, Kitamura K, Miyachi T, Maruyama H, Honjo K, Mimori Y, Noda K, Watanabe C 978325200 Presentation
Extracting tissue volumes semi-automatically for brain-behavior stroke studies FICCDAT: Neurorehabilitation Honjo K, Gao FQ, Gibson E, Scott CJM, Ganda A, Stebbins G, Lobaugh N, Zhou XJ, Graham SJ, Stuss DT, Nyenhuis DL, Black SE -28800 Presentation
Thalamic volume is related to side of stroke, stroke volume and post-stroke cognitive impairment Vas-Cog Honjo K, Nyenhuis DL, Gao FQ, Scott CJM, Zhou XJ, Graham SJ, Rangwala N, Stebbins GT, Gibson E, Ganda A, Lobaugh NJ, Marola J, Stuss DT, Black SE -28800 Presentation
Extracting tissue compartment volumes semi-automatically for brain-behavior stroke studies Vas-Cog Honjo K, Gao FQ, Gibson E, Scott CJM, Ganda A, Stebbins GT, Lobaugh NJ, Zhou XJ, Rangwala N, Graham SJ, Stuss DT, Pedelty LL, Nyenhuis DL, Black SE -28800 Presentation
Thalamic volume is related to side and location of stroke, stroke volume and post-stroke cognitive impairment Canadian Stroke Congress Scott CJM, Honjo K, Nyenhuis DL, Gao FQ, Zhou XJ, Graham SJ, Rangwala N, Stebbins GT, Gibson E, Ganda A, Lobaugh NJ, Marola J, Stuss DT, Black SE -28800 Presentation
The sensitivity and specificity of subdomain scores from the NINDS-CSN Harmonization 60 Minute Protocol in subjects following ischemic stroke Fifth Congress of the International Society of Behavioral and Cognitive Vascular Disorders (Vas-Cog) Nyenhuis DL, Ganda A, Rangwala N, Gao F, Gibson E, Graham S, Honjo K, Lobaugh NJ, Marola J, Pedelty L, Scott CJM, Stebbins GT, Stuss DT, Zhou XJ, , Black SE -28800 Presentation
Sensitivity and specificity of the NINDS-CSN Harmonization VCI Neuropsychology Protocols in subjects following ischemic stroke Fifth Congress of the International Society of Behavioral and Cognitive Vascular Disorders (Vas-Cog) Nyenhuis, DL, Ganda A, Gao F, Gibson E, Graham S, Honjo K, Lobaugh NJ, Marola J, Pedelty L, Rangwala N, Scott CJM, Stebbins GT, Stuss DT, Zhou XJ, Black SE -28800 Presentation
Association between white matter hyperintensities, brain atrophy and cognition in Alzheimer’s disease Canadian Conference on Dementia Dossa F, Nestor SM, Gao FQ, Scott CJM, Ramirez J, Honjo K, Chan J, McNeely A, Ganda A, Stuss DT, Black SE -28800 Presentation
Validity of the NINDS-CSN VCI neuropsychological protocols is supported in a sample of ischemic stroke patients AHA International Stroke Conference Nyenhuis DL, Ganda A, Rangwala N, Gao F, Gibson E, Graham S, Honjo K, Lobaugh NJ, Marola J, Pedelty L, Scott CJM, Stebbins GT, Stuss DT, Zhou XJ, Black SE -28800 Presentation

Education

  • 1997: Bachelor, Medicine (M.D.), Shimane Medical University Shimane, Japan (1991 to 1997)
  • 2004: Ph.D., Graduate School of Biomedical Sciences, Hiroshima University Hiroshima, Japan (2001 to 2004)
  • 2011: Postdoctorate , Baycrest Toronto, ON, Canada (2005 to present)

Academic Appointments

  • 1969–Present: Post-Doctoral Fellow, Kunin-Lunenfeld Applied Research Unit (KLARU), Baycrest, Toronto, ON, Canada (Supervisor: Dr. Nicolaas Paul L.G. Verhoeff)
  • 2001–2004: Postgraduate in Neurology, Department of Clinical Neuroscience and Therapeutics, Division of Integrated Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
  • 1999–2001: Resident in Internal Medicine, Department of Internal Medicine, Teraoka Memorial Hospital, Hiroshima, Japan
  • 1998–1999: Resident in Neurology, Department of Clinical Neuroscience and Therapeutics, Division of Integrated Medical Science, Hiroshima University Hospital, Hiroshima, Japan

Reviewership

Membership

  • 1998–2011: Japanese Society of Neurology
  • 1998–2011: Japanese Society of Internal Medicine
  • 1998–2011: Japan Geriatrics Society
  • 2002–2011: Japanese Society of Cerebral Blood Flow and Metabolism

Distinctions and Awards

  • 2003: Clinical Research Award, Hiroshima Clinical Cerebral Blood Flow and Metabolism, Japan

Certificates and Licensure

  • Medical License (Japan), in 1998
  • Board Certification in Neurology (Japan), in 2003
  • Japanese Board of Internal Medicine (Japan), in 2004

Curriculum Vitae

Contact

Kunin-Lunenfeld Applied Research Unit
Baycrest
3560 Bathurst Street, 722
Toronto, ON M6A 2E1
Canada Phone: 416-785-2500 x.3149 Email: khonjo@klaru-baycrest.on.ca Fax: 416-785-4295