John, Michael Sasha Dr.
Dr. Michael Sasha John
Research Associate Rotman Research Institute, Baycrest
Assistant Professor, Cross-appointment Institute of Biomaterials and Biomedical Engineering, University of TorontoEntrepreneur /Inventor
- Master Systems Inc.
- U.S. Patent Nos.: 7,899,545; 7,894,905; 7,894,903; 7,819,812; 7,747,318; 7,471,978; 7,399,282; 7,014,613; 6,602,202; 6,463,328; 6,385,486; 6,066,163
Research Focus
My research strives to shed light on how the human auditory system processes sound. This effort has resulted in clinical devices which are used to evaluate hearing in both infants and adults. By way of evaluating neurophysiological correlates of auditory processing key advances in the field of objective audiometry using auditory steady-state responses (ASSRs) have been made. My early work with Dr. Terry Picton helped form a solid foundation for what we have termed the multiple auditory steady-state response (MASTER) technique and demonstrated how the manipulation of several key parameters either improved or degraded the performance of this testing technique. The understanding obtained in these early studies, has recently enabled us to make several advances that have significantly increased the power, speed, accuracy, and comprehensiveness of the technique. Our laboratory has introduced new types of stimuli that evoke more robust responses and thereby permit a more rapid and accurate evaluation of the auditory system's capacity for detecting both frequency modulation and amplitude modulation. The responses evoked by these novel stimuli are positively correlated with an individual's speech processing abilities. The technique may serve to objectively quantify both the processing deficiencies that underlie hearing deficits, and also the efficacy of hearing aid devices in overcoming these deficits.
Publications
| Title | Source (Journal/Book/Conference) | Authors/Presenters | Published On | Type |
|---|---|---|---|---|
| Optimal Detection Paradigm using Sequential Testing for Auditory Steady State Response | IERASG 2011 | Choi J, Purcell D, John MS | 1309320000 | Presentation |
| Phase stability of auditory steady state responses in newborn infants | Ear and Hearing | Choi JM, Purcell DW, John MS | 1293858000 | Journal Article |
| Intracardiac ST-Segment Monitoring in Ambulatory Patients: Variability during Normal Daily Life and Occlusion-Events | Heart Rhythm | Krucoff M, John MS, Holmes D, Foster M, Kovach R, Fischell T, Gibson MC | 1273636800 | Presentation |
| Initial Results Using an Implantable ST-Segment Monitoring System that Detects and Alerts Patients To Coronary Plaque Rupture and Ischemia | Society for Cardiovascular Angiography and Interventions (SCAI) | Gibson MC, Avezum A, John MS, Guimaraes H, Fischell T, Fischell DR, Foster M, Kovach R, Medeiros P, Piegas L, Holmes D | 1273032000 | Presentation |
| Evaluating the modulation transfer function of auditory steady state responses in the 65 Hz to 120 Hz range | Ear and Hearing | Purcell DW, John MS | 1270440000 | Journal Article |
| Initial clinical results using intracardiac electrogram monitoring to detect and alert patients during coronary plaque rupture and ischemia | Journal of the American College of Cardiology | Fischell TA, Fischell DR, Avezum A, John MS, Holmes D, Foster M, Kovach R, Medeiros P, Piegas LS, Guimaraes H, Gibson CM | 1270440000 | Journal Article |
| The Guardian: an implantable system for chronic ambulatory monitoring of acute myocardial infarction | Journal of Electrocardiology | Hopenfeld B, John MS, Fischell DR, Medeiros P, Guimarães HP, Piegas LS | 1259730000 | Journal Article |
| Use of ASSR Phase in Newborn Hearing Testing | International Evoked response Audiomety Study Group (IERASG) | Choi JM, John MS, Purcell DW | 1236056400 | Presentation |
| Multiple Auditory Steady State Responses (80-101 Hz): Effects of Ear, Gender, Handedness, Intensity and Modulation Rate | Ear and Hearing | Picton TW, van Roon P, John MS | 1233464400 | Journal Article |
| Technical principles of auditory steady-state response testing | Auditory Steady-State Response: Generation Recording, and Clinical Applications | John MS, Purcell DW | 1207368000 | Book Chapter |
| Future directions of auditory steady-state response testing | Auditory Steady-State Response: Generation Recording, and Clinical Applications | Rance G, John MS | 1207368000 | Book Chapter |
| Human auditory steady-state responses during sweeps of intensity | Ear and Hearing | Picton TW, van Roon P, John MS | 1167627600 | Journal Article |
| Simultaneous latency estimations for distortion product otoacoustic emissions and envelope following responses | Journal of the Acoustical Society of America | Purcell DW, van Roon P, John MS, Picton TW | 1136091600 | Journal Article |
| Human temporal auditory acuity as assessed by envelope following responses | Journal of the Acoustical Society of America | Purcell DW, John MS, Schneider BA, Picton TW | 1101877200 | Journal Article |
| Auditory steady-state responses and word recognition scores in normal-hearing and hearing-Impaired adults | Ear and Hearing | Dimitrijevic A, John MS, Picton TW | 1075611600 | Journal Article |
| Recording auditory steady-state responses in young infants | Ear and Hearing | John MS, Brown DK, Muir PJ, Picton TW | 1072933200 | Journal Article |
| Avoiding electromagnetic artifacts when recording auditory steady-state responses | Journal of the American Academy of Audiology | Picton TW, John MS | 1072933200 | Journal Article |
| Efficient stimuli for evoking auditory steady-state responses | Ear and Hearing | John MS, Dimitrijevic A, Picton TW | 1064980800 | Journal Article |
| Human auditory steady-state responses | International Journal of Audiology | Picton TW, John MS, Purcell DW, Dimitrijevic A | 1054440000 | Journal Article |
| Human auditory steady-state responses: The effects of recording technique and state of arousal | Anesthesia & Analgesia | Picton TW, John MS, Purcell DW, Plourde G | 1041397200 | Journal Article |
| Concurrent measurement of distortion product otoacoustic emissions and auditory steady state evoked potentials | Hearing Research | Purcell DW, John MS, Picton TW | 1041397200 | Journal Article |
| Auditory steady-state responses and word recognition scores in normal hearing and hearing-impaired adults | XVIII IERASG BIENNIAL SYMPOSIUM | Dimitrijevic A, John MS, Picton TW | 1041397200 | Presentation |
| Use of modulated noise in newborn hearing screening | XVIII IERASG BIENNIAL SYMPOSIUM | John MS, Brown D, Muir P, Picton TW | 1041397200 | Presentation |
| Auditory steady-state responses to exponential modulation envelopes | Ear and Hearing | John MS, Dimitrijevic A, Picton TW | 1017637200 | Journal Article |
| Possible roles for the auditory steady-state responses in identification, evaluation and management of hearing loss in infancy | Audiology Today | Picton TW, John MS, Dimitrijevic A | 1009861200 | Journal Article |
| Advantages and caveats when recording steady-state responses to multiple simultaneous stimuli | Journal of the American Academy of Audiology | John MS, Purcell DW, Dimitrijevic A, Picton TW | 1009861200 | Journal Article |
| Multiple auditory steady-state responses | Annals of Otology, Rhinology, and Laryngology | Picton TW, Dimitrijevic A, John MS | 1009861200 | Journal Article |
| Estimating the audiogram using multiple auditory steady-state responses | Journal of the American Academy of Audiology | Dimitrijevic A, John MS, van Roon P, Purcell DW, Adamonis J, Ostroff J, Nedzelski JM, Picton TW | 1009861200 | Journal Article |
| Possible roles for the auditory steady-state responses in fitting hearing aids | A Sound Foundation Through Early Amplification | Picton TW, Dimitrijevic A, van Roon P, John MS, Reed M, Finkelstein H | 1009861200 | Book Chapter |
| The use of phase in the detection of auditory steady-state responses | Clinical Neurophysiology | Picton TW, Dimitrijevic A, John MS, van Roon P | 999316800 | Journal Article |
| Human auditory steady-state responses to tones independently modulated in both frequency and amplitude | Ear and Hearing | Dimitrijevic A, John MS, van Roon P, Picton TW | 986014800 | Journal Article |
| Weighted averaging of steady-state responses | Clinical Neurophysiology | John MS, Dimitrijevic A, Picton TW | 983422800 | Journal Article |
| Multiple auditory steady-state responses to AM and FM stimuli | Audiology & Neurotology | John MS, Dimitrijevic A, van Roon P, Picton TW | 978325200 | Journal Article |
| Human auditory steady-state responses to amplitude-modulated tones: Phase and latency measurements | Hearing Research | John MS, Picton TW | 951886800 | Journal Article |
| MASTER: A Windows program for recording multiple auditory steady-state responses | Computer Methods and Programs in Biomedicine | John MS, Picton TW | 949381200 | Journal Article |
| Intracerebral sources of human auditory-evoked potentials | Audiology & Neurotology | Picton TW, Alain C, Woods DL, John MS, Scherg M, Valdes-Sosa P, Bosch-Bayard J, Trujillo NJ | 920264400 | Journal Article |
| Auditory steady-state responses: Using phase to measure latency | SOCIETY FOR NEUROSCIENCE ABSTRACTS | John MS, Picton TW, Alain C | 910414800 | Abstract |
| Multiple Auditory Steady-state Responses (MASTER): Stimulus and Recording Parameters | Audiology | John MS, Lins OG, Boucher B, Picton TW | 888728400 | Journal Article |
Education
- 2000: PhD, Medical Science, Institute of Medical Science Faculty of Medicine, University of Toronto, 7213 Medical Sciences Building, 1 King's College Circle, Toronto, ON
- 1996: MSc, Psychiatry, Departmant of Psychiatry, McGill University, 845 Sherbrooke Street West, Montreal, Quebec, Canada
- 1991: BA, Psychology, Department of Psychology, Reed College, 3203 SE Woodstock Boulevard Portland, Oregon
Academic Appointments
- 2003–Present: Research Associate, Rotman Research Institute, Baycrest, Toronto, Canada
- 2000–2003: Post-Doctoral Fellow, Rotman Research Institute, Baycrest, Toronto, Canada
- 2007–2010: Assistant Professor, Cross-appointment, Institute of Biomaterials and Biomedical Engineering, University of Toronto
Reviewership
Consulting
- 2006–2008: Angel-Medical Inc.
- 2005–2006: Neuropace Inc.
- 2002–Present: Bio-Logic Systems Corp (Natus)
- 2003–2006: Intelligent Hearing Systems Inc.
Editorial Board
- 2001–2005: Clinical Neurophysiology
- 2003–2004: International Journal of Audiology
- 2002–2003: Hearing Research
- 2004–2009: Ear and Hearing Guest Section Editor
Research Projects
External
-
2000–2003:
Evoked Potential Audiometry
Collaborators: Picton, Stapells, JohnSponsors: CIHR, 236,082
MT-14362
-
2002–2003:
A Screening Test for Hearing Using Auditory Steady-State Responses
Collaborators: Picton, John, BrownSponsors: CIHR, 95,094
-
2004–2007:
Steady-State Response Audiometry
Collaborators: Stapells, John, DimitrijevicSponsors: CIHR, 354,652
Operating Grant
-
2005–2008:
Improving Methods of Evoked Potential Audiometry
Collaborators: JohnSponsors: CIHR, 206,733
-
2008–2009:
Combining musical training through VMI and Smart Kids Learning Software
Collaborators: Chau, John, MorenoSponsors: ORCP Proof Of Principal Grant (Ministry of Research and Innovation), 50,000
-
2009–2010:
Pre-commercialization of the VMI Virtual Music Instrument and Smarterkids training
Collaborators: Chau, John, MorenoSponsors: NSERC/CIHR: Intellectual Property Mobilization Program, 24,000
-
2009–2010:
Acute Ischemia Monitor Utilizing Subcutaneous Electrodes
Collaborators: Hopenfeld, John, Johnson, Fischell, Fischell, HarwoodSponsors: NIH Small Business Innovation Grant (SBIR), 168,483
1R43HL96158-01
-
2010–2012:
Neurophysiological Modulation Transfer Functions of Auditory Neuropathy Patients
Collaborators: John, Purcell, DimitrijevicSponsors: The Hearing Foundation of Canada, 22,500
-
2011–2012:
Acute Ischemia Monitor Utilizing Subcutaneous Electrodes
Collaborators: Hopenfeld, John, Johnson, Fischell, Fischell, HarwoodSponsors: NIH Small Business Innovation Grant (SBIR Phase II), 1,400,000
Internal
-
2010:
Real-time protocol adjustment for auditory steady-state response tests using a modified bootstrap design
Collaborators: Terry Picton
Institutions: Rotman Research Institute, Toronto -
2010:
Steady-State Response Audiometry in Neuropathy
Collaborators: Andrew Dimitrijevic
Institutions: Rotman Research Institute, University of California, Irvine -
2001–2003:
Post-Doctoral Fellowship Award
Institutions: Rotman Research Institute , 64,000
Links
Contact
The Rotman Research InstituteBaycrest
3560 Bathurst Street
Toronto, Ontario
Canada M6A 2E1 Phone: 416-785-2500 x3591 Email: sjohn
rotman-baycrest.on.ca Fax: 416-785-2862
Baycrest is an academic health sciences centre fully affiliated with the University of Toronto
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