Strother, Stephen Dr.
Dr. Stephen Strother
Senior Scientist Rotman Research Institute, Baycrest
Professor Department of Medical Biophysics, University of Toronto
Research Focus
My research is directed at developing and testing a set of optimal experimental planning and analysis tools for neuroimaging researchers that are coupled with our own, and others', state-of-the-art neuroimaging research data-bases. The ultimate goal is to optimize and merge neuroimaging and meta-data in a more principled manner to yield new insights into human mental functions, how they are changed with normal aging, and compromised by damage and disease in the aging brain.
As an example we are focusing on optimized experimental neuroimaging protocols for Vascular Cognitive Impairment and stroke using multiple behavioural tasks that take only a short time to complete, and are suitable as clinical probes of cognitive brain function. Our goal is to develop a database library of such probes to assist in designing new multi-task protocols that can be tailored to a particular clinical or research goal as a function of age, and to predict likely prognosis and treatment outcomes.
These goals require optimization of the experimental designs, data-analysis algorithms and associated software tools being developed for cognitive neuroscience and clinical fMRI as a function of age, in the so-called "fMRI processing pipeline". We do this with a particular focus on brain networks measured using multivariate machine learning models and resampling techniques from the field of statistical learning theory. In particular we are developing a quantitative testing framework that focuses on prediction and reproducibility metrics called NPAIRS. This software package combined with the Partial Least Square tools developed by Randy McIntosh is distributed as an opensource Java package.
Neuroimaging processing pipeline choices pose a range of critical issues, particularly which tools/packages to use for a particular experiment. All too often these choices are resolved expediently in favour of availability, familiarity and ease of use in the hope that the exact choices will not significantly change the experimental results. However, there is growing evidence that new insights into human brain function may be obscured by poor choices in the image processing pipeline particularly as a function of age and disease.
Publications
| Title | Source (Journal/Book/Conference) | Authors/Presenters | Published On | Type |
|---|---|---|---|---|
| Complex and magnitude-only preprocessing of 2D and 3D BOLD fMRI data at 7 Tesla | Mag. Res. Medicine | Barry RL, Strother SC, Gore JC | 1313121600 | Journal Article |
| PHYCAA: Data-Driven Measurement and Removal of Physiological Noise in BOLD fMRI | NeuroImage | Churchill N, Yourganov G, Spring R, Rasmussen P, Lee W, Ween J, Strother SC | 1313121600 | Journal Article |
| Optimizing preprocessing and analysis pipelines for single-subject fMRI. I. Standard temporal motion and physiological noise correction methods. | Human Brain Mapping | Churchill NW, Oder A, Abdi H, Tam F, Lee W, Thomas C, Ween JE, Graham SJ, Strother SC | 1306814400 | Journal Article |
| Dimensionality estimation for optimal detection of functional networks in BOLD fMRI data. | NeuroImage | Yourganov G, Chen X, Lukic AS, Grady CL, Small SL, Wernick MN, Strother SC | 1305432000 | Journal Article |
| A mutual information-based metric for evaluation of fMRI data-processing approaches. | Human Brain Mapping | Afshin-Pour B, Soltanian-Zadeh H, Hossein-Zadeh GA, Grady CL, Strother SC | 1301630400 | Journal Article |
| Data-driven optimization and evaluation of 2D EPI and 3D PRESTO for BOLD fMRI at 7 Tesla: I. Focal coverage. | NeuroImage | Barry RL, Strother SC, Gatenby JC, Gore JC | 1301630400 | Journal Article |
| Reproducible Pipelines, Statistical Parametric Maps and Strong Inference in fMRI | NEUROIMAGE | Strother SC | 1299906000 | Abstract |
| A new tablet for writing and drawing during functional MRI | Human Brain Mapping | Tam F, Churchill NW, Strother SC, Graham SJ | 1296536400 | Journal Article |
| Data warehousing methods and processing infrastructure for brain recovery research | Archives of Italian Biology | Gee T, Kenny S, Price CJ, Seghier ML, Small SL, Leff AP, Pacurar A, Strother SC | 1283313600 | Journal Article |
| Functional connectivity metrics during stroke recovery | Archives of Italian Biology | Yourganov G, Schmah T, Small SL, Rasmussen PM, Strother SC | 1283313600 | Journal Article |
| Occupation attributes relate to location of atrophy in frontotemporal lobar degeneration | Neuropsychologia | Spreng RN, Rosen H, Strother S, Chow TW, Diehl-Schmid J, Freedman M, Graff-Radford N, Hodges J, Lipton A, Mendez M, Morelli S, Black SE, Miller BL, Levine B | 1283140800 | Journal Article |
| The NPAIRS Computational Statistics Framework for Data Analysis in Neuroimaging | Proc. 19th Int. Conf. on Computational Statistics: Refereed Keynote, Invited and Contributed Papers | Strother SC, Oder A, Spring R, Grady C | 1280635200 | Technical Paper |
| Machine learning in medical imaging | IEEE Signal Processing Magazine | Wernick MN, Yang Y, Brankov JG, Yourganov G, Strother SC | 1276488000 | Journal Article |
| Group specific optimisation of fMRI processing steps for child and adult data | NeuroImage | Evans JW, Todd RM, Taylor MJ, Strother SC | 1267506000 | Journal Article |
| Comparing classification methods for longitudinal fMRI studies. | Neural Computation | Schmah T, Yourganov G, Zemel RS, Hinton GE, Small SL, Strother SC | 1262322000 | Journal Article |
| Longitudinal cerebral blood flow changes during speech in hereditary ataxia. | Brain and Language | Sidtis JJ, Strother SC, Naoum A, Rottenberg DA, Gomez C | 1262322000 | Journal Article |
| A multivariate analysis of age-related differences in default mode and task-positive networks across multiple cognitive domains. | Cerebral Cortex | Grady CL, Protzner AB, Kovacevic N, Strother SC, Afshin-Pour B, Wojtowicz M, Anderson JA, Churchill N, McIntosh AR | 1262322000 | Journal Article |
| Better BOLD fMRI across the lifespan from children to the elderly | Rotman Rounds | Strother SC | 1257742800 | Presentation |
| Generative versus discriminative training of RBMs for classification of fMRI images | Advances in Neural Information Processing Systems | Schmah T, Hinton G, Zemel RS, Small SL, Strother SC | 1257051600 | Technical Paper |
| Reproducible pipelines, satistical parametric maps and strong inference in fMRI studies of cognitive aging | Strother SC, Afshipour B, Yourganov G, Oder A, Grady C | 1245297600 | Presentation | |
| How Close to Zero is the Estimated Zero in BOLD fMRI Analyses as a Function of Age and Task? | NEUROIMAGE | Afshinpour B, Anderson J, Churchill N, Kovacevic N, Grady C, Strother S | 1245297600 | Abstract |
| Optimizing Activation Detection with Better Dimensionality Estimation in BOLD fMRI | NEUROIMAGE | Yourganov G, Lukic A, Grady C, Wernick M, Strother S | 1245297600 | Abstract |
| Functional connectivity reveals inefficient working memory systems in post-traumatic stress disorder | Psychiatry Research: Neuroimaging | Shaw ME, Moores KA, Clark RC, McFarlane AC, Strother SC, Bryant RA, Brown GC, Taylor JD | 1243828800 | Journal Article |
| System for computerized writing and drawing during fMRI | Tam F, Churchill N, Strother SC, Graham SJ | 1240027200 | Presentation | |
| Developing clinical fMRI for stroke patients | Graham SJ, Strother SC | 1237521600 | Presentation | |
| Evaluation and optimization of fMRI single-subject processing pipelines with NPAIRS and second-level CVA | Magnetic Resonance Imaging | Zhang J, Anderson JR, Liang LC, Pulapura SK, Gatewood L, Rottenberg DA, Strother SC | 1233464400 | Journal Article |
| Generative versus discriminate RBM models for classification of fMRI images | NIPS 2008 | Schmah T, Hinton G, Zemel R, Small SL, Strother SC | 1228712400 | Abstract |
| Pacific Rim collaborations: a Canadian perspective | Brain Imaging and Behavior | Grady C, Strother SC | 1228107600 | Journal Article |
| Optimizing the design and analysis of clinical functional magnetic resonance imaging research studies | Biological Psychiatry | Carter CS, Heckers S, Nichols T, Pine DS, Strother S | 1226725200 | Journal Article |
| Evaluation and comparison of GLM- and CVA-based fMRIprocessing pipelines with Java-based fMRI processing pipeline evaluation system | Neuroimage | Zhang J, Liang L, Anderson JR, Gatewood L, Rottenberg DA, Strother SC | 1216094400 | Journal Article |
| A java-based fMRI processing pipeline evaluation system for assessment of univariate general linear model and multivariate canonical variate analysis-based pipelines | NeuroInformatics | Zhang J, Liang L, Anderson JR, Gatewood L, Rottenberg DA, Strother SC | 1210046400 | Journal Article |
| Towards Shorter Scan Times Using Subject-Dependent Processing Pipelines for Clinical Tasks in fMRI | ISMRM 16th Scientific Meeting and Exhibition | Lee W, Mraz R, Tam F, Graham FJ, Strother SC | 1209787200 | Presentation |
| New horizons for the next era of human brain imaging, cognitive, and behavioral research: Pacific Rim interactivity | Brain Imaging and Behavior | Van Horn JD, Bandettini PA, Cheng K, Egan GF, Stenger VA, Strother S, Toga AW | 1209182400 | Journal Article |
| Multivariate Assessment of Preprocessing Choices as a Function of Age and Task | Rotman Rounds | Strother SC | 1199163600 | Presentation |
| Choosing Optimal Data Analysis Models in fMRI Studies: Interactions with Age and Task | Intelligent Signal Processing Group | Strother SC | 1199163600 | Presentation |
| Reproducibility across analysis streams | IPAM: Mathematics in Brain Imaging | Strother SC | 1199163600 | Presentation |
| Assessing fMRI Processing Choices as a Function of Age and Task | MRI Group Monthly Rounds: Medical Biophysics | Strother SC | 1199163600 | Presentation |
| Bayesian kernel methods for analysis of functional neuroimages | IEEE Transactions on Medical Imaging | Lukic AS, Wernick MN, Tzikas DG, Xu C, Likas A, Galatsanos NP, Yongyi Y, Fuqiang Z, Strother SC | 1197867600 | Journal Article |
| Effect of spatial alignment transformations in PCA and ICA of functional neuroimages | IEEE Transactions on Medical Imaging | Lukic AS, Wernick MN, Yongyi Yang, Kai Hansen L, Arfanakis K, Strother SC | 1187323200 | Journal Article |
| Image processing in fMRI | Medical Biophysics summer-student lecture series | Strother SC | 1167627600 | Presentation |
| Dysfunction of dorsolateral prefrontal cortex in antipsychotic-naïve schizophreniform psychosis. | Psychiatry Research: Neuroimaging | Harrison BJ, Yücel M, Shaw M, Brewer WJ, Nathan PJ, Strother SC, Olver JS, Egan GF, Velakoulis D, McGorry PD, Pantelis C | 1164171600 | Journal Article |
| Predictive Modeling in fMRI pipelines: Some uses and caveats | Rotman Rounds | Strother SC | 1163998800 | Presentation |
| Exploring predictive and reproducible modeling with the single-subject FIAC dataset | Human Brain Mapping | Chen X, Pereira F, Lee W, Strother SC, Mitchell T | 1163566800 | Journal Article |
| Kernel methods for functional neuroimaging analysis | 2006 Fortieth Asilomar Conference on Signals, Systems and Computers | Lukic AS, Wernick MN, Tzikas DG, Chen X, Likas A, Galatsanos NP, Yang Y, Zhao F, Strother SC | 1162098000 | Presentation |
| FMRI Image Processing & Data Analysis Choices: Do They Matter? | SOCIETY FOR NEUROSCIENCE ABSTRACTS | Strother SC | 1160712000 | Presentation |
| Mapping cerebral blood flow during speech production in hereditary ataxia | Neuroimage | Sidtis JJ, Gomez C, Naoum A, Strother SC, Rottenberg DA | 1136091600 | Journal Article |
| Evaluating brain activity in obsessive-compulsive disorder: Preliminary insights from a multivariate analysis | Psychiatry Research: Neuroimaging | Harrison BJ, Yucel M, Shaw M, Maruff P, Kyrios M, Brewer WJ, Strother SC, Nathan PJ, Scott AM, Pantelis C | 1136091600 | Journal Article |
| Motivation and synthesis of the FIAC experiment: Reproducibility of fMRI results across expert analyses | Human Brain Mapping | Poline JB, Strother SC, Dehaene-Lambertz G, Egan G, Lancaster J | 1136091600 | Journal Article |
| Dysfunction of dorsolateral prefrontal cortex in antipsychotic-naive schizophreniform psychosis | Psychiatry Research: Neuroimaging | Harrison BJ, Yucel M, Shaw M, Maruff P, Kyrios M, Brewer WJ, Strother SC, Nathan PJ, Scott AM, Pantelis C | 1136091600 | Journal Article |
| Evaluating fMRI preprocessing pipelines: Review of preprocessing steps for BOLD fMRI | IEEE Engineering in Medicine and Biology Magazine | Strother SC | 1136091600 | Journal Article |
| NIfTI-1: An example of linking informatics tools | Linking Informatics of Neuroscience Communities Workshop | Strother SC | 1136091600 | Presentation |
| Applications of Multivariate Analysis to Imaging in Drug Development | Pfizer Global Clinical Technologies Group | Strother SC | 1136091600 | Presentation |
| Managing and Optimising fMRI Pipelines | Plenary lecture for functional Bioinformatics Resource Network (fBIRN) annual meeting | Strother SC | 1136091600 | Presentation |
| Evaluating fMRI preprocessing pipelines. | IEEE Engineering in Medicine and Biology Magazine | Strother SC | 1136091600 | Journal Article |
| Support vector machines for temporal classification of block design fMRI data | Neuroimage | LaConte S, Strother SC, Cherkassky V, Anderson J, Hu X | 1104555600 | Journal Article |
| Functional connectivity during Stroop Task performance | Neuroimage | Harrison B, Shaw M, Yucel M, Purcell R, Brewer WJ, Strother SC, Egan GF, Olver JS, Nathan PJ, Pantelis C | 1104555600 | Journal Article |
| Age and Task Interactions with Choices in the fMRI Processing Pipeline | Decoding Brain States with Machine Learning: Applications to fMRI | Strother SC | 1104555600 | Presentation |
| Abnormal cingulo-prefrontal connectivity during Stroop task performance in first episode psychosis: A PET study | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | Harrison B, Brewer WJ, Shaw M, Yucel M, Strother SC, Nathan PJ, McGorry PD, Pantelis C | 1086062400 | Abstract |
| Reversible jump Markov chain Monte Carlo signal detection in functional neuroimaging analysis | IEEE International Symposium on Biomedical Imaging | Lukic AS, Wernick MN, Galatsanos NP, Yongyi Yang, Strother SC | 1082001600 | Journal Article |
| The effect of set on the resting state in functional imaging: A role for the striatum? | Neuroimage | Sidtis JJ, Strother SC, Rottenberg DA | 1072933200 | Journal Article |
| Optimizing the fMRI data-processing pipeline using prediction and reproducibility performance metrics. I. A preliminary group analysis | Neuroimage | Strother SC, LaConte S, Hansen LK, Anderson J, Zhang J, Pulapura S, Rottenberg D | 1072933200 | Journal Article |
| Impact of inter-subject image registration on group analysis of fMRI data | International Congress Series | Ardekani BA, Bachman AH, Strother SC, Fujibayashi Y, Yonekura Y | 1072933200 | Book Chapter |
| Data-Driven Discovery in Functional Neuroimaging | RUMBA Seminar Series | Strother SC | 1072933200 | Presentation |
| Dimensionality Reduction with RVMs and RJMCMC | Computational Neuroscience UC Workshop | Strother SC, Lukic A, Wernick M | 1072933200 | Presentation |
| Optimizing fMRI processing pipelines | IPAM Graduate Summer School: Mathematics in Brain Imaging | Strother SC | 1072933200 | Presentation |
| Optimizing fMRI Processing Pipelines: A Group Study | Laboratory Visit to Seong-Gi Kim and William Eddy | Strother SC | 1072933200 | Presentation |
| Predicting performance from functional imaging data: methods matter | Neuroimage | Sidtis JJ, Strother SC, Rottenberg DA | 1064980800 | Journal Article |
| Scale for auditory speech hallucinations (SASH), reliability | SCHIZOPHRENIA RESEARCH | Stephane M, Roberts S, Nasrallah HA, Strother SC, Adityanjee D, Schulz SC, Georgopoulos AP | 1047704400 | Abstract |
| The evaluation of preprocessing choices in single-subject BOLD fMRI using NPAIRS performance metrics | Neuroimage | LaConte S, Anderson J, Muley S, Frutiger S, Hansen LK, Yacoub E, Xiaoping H, Rottenberg D, Ashe J, Strother SC | 1041397200 | Journal Article |
| Evaluating subject specific preprocessing choices in multisubject fMRI data sets using data-driven performance metrics | Neuroimage | Shaw ME, Strother SC, Gavrilescu M, Podzebenko K, Waites A, Watson J, Anderson J, Jackson G, Egan G | 1041397200 | Journal Article |
| A developer's commentary on fiswidgets | Neuroinformatics | Strother SC | 1041397200 | Journal Article |
| How to Optimize a Multivariate Analysis of fMRI Data Sets: Linear Discriminants, Confusion Matrices and Reproducibility Metrics in the NPAIRS Resampling Framework | fMRI Data Center Informatics Summer Workshop | Strother SC | 1041397200 | Presentation |
| Data-driven discovery in functional neuroimaging | Rotman Rounds | Strother SC | 1041397200 | Presentation |
| Data-Driven Discovery in Functional Neuroimaging | Data Processing Methods in Neuroscience Seminar | Strother SC | 1041397200 | Presentation |
| Production and dosimetry of [14O]water for PET activation studies. | Applied Radiation and Isotopes | Sajjad M, Zaini MR, Liow JS, Rottenberg DA, Strother SC | 1036126800 | Journal Article |
| An ICA algorithm for analyzing multiple data sets | International Conference on Image Processing | Lukic AS, Wernick MN, Hansen LK, Strother SC | 1032235200 | Journal Article |
| A spatially robust ICA algorithm for multiple fMRI data sets | IEEE International Symposium on Biomedical Imaging | Lukic AS, Wernick MN, Hansen LK, Anderson J, Strother SC | 1026014400 | Journal Article |
| A reversible jump Markov chain Monte Carlo algorithm for analysis of functional neuroimages | International Conference on Image Processing | Lukic AS, Wernick MN, Galatsanos NP, Yongyi Yang, Strother SC | 1024891200 | Journal Article |
| Evaluation of an MRI-based partial volume correction for PET | JOURNAL OF NUCLEAR MEDICINE | Liow J, Zaini M, Rehm K, Strother SC, Anderson J, Schaper K, Rottenberg D | 1024113600 | Abstract |
| The quantitative evaluation of functional neuroimaging experiments: The NPAIRS data analysis framework | Neuroimage | Strother SC, Anderson J, Hansen LK, Kjems U, Kustra R, Siditis J, Frutiger S, Muley S, LaConte S, Rottenberg D | 1009861200 | Journal Article |
| Abnormal functional connectivity in post-traumatic stress disorder | Neuroimage | Shaw M, Strother SC, McFarlane AC, Morris P, Anderson J, Clark CR, Egan GF | 1009861200 | Journal Article |
| The quantitative evaluation of functional neuroimaging experiments:Mutual information learning curves | Neuroimage | Kjems U, Hansen LK, Anderson J, Frutiger SA, Sidtis JJ, Rottenberg D, Strother SC | 1009861200 | Journal Article |
| An evaluation of methods for detecting brain activations from functional neuroimages | Artificial Intelligence in Medicine | Lukic AS, Wernick MN, Strother SC | 1009861200 | Journal Article |
| Production and dosimetry of [O-14]water for PET activation studies | Applied Radiation and Isotopes | Sajjad M, Liow J-S, Zaini MR, Rottenberg DA, Strother SC | 1009861200 | Journal Article |
| Cluster analysis of activity time-series in motor learning | Human Brain Mapping | Balslev D, Nielsen FA, Frutiger SA, Sidtis JJ, Christiansen TB, Svarer C, Strother SC, Rottenberg DA, Hansen LK, Paulson OB, Law I | 1009861200 | Journal Article |
| A signal-detection approach for analysis of functional neuroimages | IEEE Nuclear Science Symposium Conference Record | Lukic AS, Wernick MN, Galatsanos NP, Yongyi Yang, Strother SC | 1004850000 | Journal Article |
| Evaluating preprocessing choices in single-subject BOLD-fMRI studies using data-driven performance metrics | NEUROIMAGE | LaConte S, Strother SC, Anderson J, Muley S, Frutiger S, Hansen LK, Yacob E, Hu XP, Rottenberg D | 991368000 | Abstract |
| "lyngby" a Matlab toolbox for fMRI analysis: Results of a user questionnaire | NEUROIMAGE | Hansen LK, Nielsen FA, Liptrot M, Strother SC, Lange N, Gade A, Rottenberg DA, Paulson OB | 991368000 | Abstract |
| Abnormal functional connectivity in post-traumatic stress disorder: insight from multivariate analysis | NEUROIMAGE | Shaw M, Strother SC, Anderson J, Egan GF, Clark R | 991368000 | Abstract |
| Effects of changes in experimental design on PET studies of isometric force | Neuroimage | Muley SA, Strother SC, Ashe J, Frutiger SA, Anderson JR, Sidtis JJ, Rottenberg DA | 978325200 | Journal Article |
| Generalizable singular value decomposition for ill-posed datasets | Advances in Neural Information Processing Systems | Kjems U, Hansen LK, Strother SC | 978325200 | Book Chapter |
| Consensus Inference in Neuroimaging | Neuroimage | Hansen LK, Nielsen FA, Strother SC, Lange N | 978325200 | Journal Article |
| Penalized discriminant analysis of [O-15]-water PET brain images with prediction error selection of smoothness and regularization hyperparameters | IEEE Transactions on Medical Imaging | Kustra R, Strother SC | 978325200 | Journal Article |
| Re-examining the correlation between H215O delivery and signal size: Towards shorter, more efficient PET sessions | Physiological Imaging of the Brain with PET | Morenu-Cantu JJ, Liow J-S, Sajjad M, Rottenberg DA, Strother SC | 978325200 | Book Chapter |
| Establishing behavioural correlates of functional imaging signals | Physiological Imaging of the Brain with PET | Sidtis JJ, Anderson JR, Strother SC, Rottenberg DA | 978325200 | Book Chapter |
| Multivariate predictive relationship between kinematic and functional activation patterns in a PET study of visuomotor learning | Neuroimage | Frutiger S, Strother SC, Anderson JR, Sidtis JJ, Arnold JB, Rottenberg DA | 973054800 | Journal Article |
| Fast PET scanning for brain activation studies with [O-14]water | JOURNAL OF NUCLEAR MEDICINE | Sajjad M, Liow JS, Zaini MR, Rottenberg DA, Strother SC | 960004800 | Abstract |
| Comparing reconstruction algorithms using a multi-variate analysis | IEEE Transactions on Nuclear Science | Liow JS, Anderson JR, Strother SC | 959832000 | Journal Article |
| Comparison of voxel- and volume-of-interest-based analyses in FDG PET scans of HIV positive and healthy individuals | Journal of Nuclear Medicine | Liow JS, Rehm K, Strother SC, Anderson JR, Morch N, Hansen LK, Schaper KA, Rottenberg DA | 946702800 | Journal Article |
| Arithmetic principles of two-dimensional and three-dimensional reconstructions | Neurosurgery: The Scientific Basis of Clinical Practice | Strother SC, Liow J-L | 946702800 | Book Chapter |
| On the independent components of functional neuroimages | International Workshop on Independent Component Analysis and Blind Signal Separation | Petersen KS, Hansen LK, Kolenda T, Rostrup E, Strother SC | 946702800 | Book Chapter |
| An evaluation of methods for detecting brain activations from PET or fMRI images | IEEE Nuclear Science Symposium | Lukic AS, Wernick MN, Strother SC | 940737600 | Journal Article |
| Establishing functional relationships between imaging data and speech production in cerebellar ataxia using perceptual ratings, acoustic analysis, and PET | BRAIN AND LANGUAGE | Sidtis JJ, Gomez C, Anderson JR, Strother SC, Rottenberg DA | 940737600 | Abstract |
| Comparison of matched BOLD and FAIR 4.0T-fMRI with [O-15]water PET brain volumes | Medical Physics | Zaini MR, Strother SC, Anderson JR, Liow J-S, Kjems U, Tegeler C, Kim S-G | 926654400 | Journal Article |
| Are brain functions really additive? | Neuroimage | Sidtis JJ, Strother SC, Anderson JR, Rottenberg DA | 925531200 | Journal Article |
| Enhancing the multivariate signal of [O-15] water PET studies with a new nonlinear neuroanatomical registration algorithm | IEEE Transactions on Medical Imaging | Kjems U, Strother SC, Anderson J, Law I, Hansen LK | 924321600 | Journal Article |
| Plurality and resemblance in fMRI data analysis | Neuroimage | Lange N, Strother SC, Anderson JR, Nielsen FA, Holmes A, Kolenda T, Savoy R, Hansen LK | 915166800 | Journal Article |
| Generalizable patterns in neuroimaging: How many principal components? | Neuroimage | Hansen LK, Larsen J, Nielsen FA, Strother SC, Rostrup E, Savoy R, Lange N, Sidtis J, Svarer C, Paulson OB | 915166800 | Journal Article |
| Reproducibility of BOLD-based functional MRI obtained at 4T | Human Brain Mapping | Tegeler C, Strother SC, Anderson JR, Kim S-G | 915166800 | Journal Article |
| Establishing functional relationships between data and speech production in cerebellar ataxia using perceptual ratings, acoustic signals, and PET | Brain and Language | Sidtis JJ, Gomez C, Anderson JR, Strother SC, Rottenberg DA | 915166800 | Journal Article |
| A symbolic environment for visualizing activated foci in functional neuroimaging datasets | Medical Image Analysis | Rehm K, Lakshminaryan K, Frutiger S, Schaper KA, Sumners DW, Strother SC, Anderson JR, Rottenberg DA | 883630800 | Journal Article |
| On the detection of activation patterns using principal components analysis | Quantitative Functional Brain Imaging with Positron Emission Tomography | Ardekani BA, Strother SC, Anderson JR, Law I, Paulson OB, Kanno I, Rottenberg DA | 883630800 | Book Chapter |
| Measuring activation pattern reproducibility using resampling techniques | Quantitative Functional Brain Imaging with Positron Emission Tomography | Strother SC, Rehm K, Lange N, Anderson JR, Schaper KA, Hansen LK, Rottenberg DA | 883630800 | Book Chapter |
| Predicting speech rate in normal and ataxic speakers from functional imaging data | Brain and Language | Sidtis JJ, Gomez C, Anderson JR, Strother SC, Rottenberg DA | 883630800 | Journal Article |
| The effect of image smoothing on a disease specific pattern of cerebral atrophy for HIV seropositive subjects in PET FDG studies. | JOURNAL OF NUCLEAR MEDICINE | Liow JS, Strother SC, Anderson JR, Rehm K, Schaper KA, Rottenberg DA | 865137600 | Abstract |
| Activation pattern reproducibility: Measuring the effects of group size and data analysis models | Human Brain Mapping | Strother SC, Lange N, Anderson JR, Schaper KA, Rehm K, Hansen LK, Rottenberg DA | 852094800 | Journal Article |
| Improved resolution for PET volume imaging through three-dimensional iterative reconstruction | Journal of Nuclear Medicine | Liow J-S, Strother SC, Rehm K, Rottenberg DA | 852094800 | Journal Article |
| Nonlinear versus linear models in functional neuroimaging: Learning curves and generalization crossover | Lecture Notes in Computer Science | Morch N, Hansen LK, Strother SC, Svarer C, Rottenberg DA, Lautrup B, Savoy R, Paulson OB | 852094800 | Journal Article |
| Quantification of dynamic FDOPA scans for 3D PET without scatter correction | JOURNAL OF NUCLEAR MEDICINE | Liow JS, Strother SC, Rottenberg DA | 833774400 | Abstract |
| Signal and noise tradeoffs with scatter correction for 3D PET [O-15]water brain activation studies | JOURNAL OF NUCLEAR MEDICINE | Liow JS, Rehm K, Anderson JR, Strother SC, Rottenberg DA | 833774400 | Abstract |
| Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia | Journal of Nuclear Medicine | Rottenberg DA, Sidtis JJ, Strother SC, Schaper KA, Anderson JR, Nelson MJ, Price RW | 820472400 | Journal Article |
| [15O]water PET: More 'noise' than Signal? | Quantification of Brain Function using PET | Strother SC, Sidtis JJ, Anderson JR, Schaper K, Rottenberg DA | 820472400 | Book Chapter |
| Data Processing Summary | Quantification of Brain Function using PET | Strother SC | 820472400 | Book Chapter |
| Linear models of orthogonal subspaces and networks from functional activation pet studies of the human brain | INFORMATION PROCESSING IN MEDICAL IMAGING COMPUTATIONAL IMAGING AND VISION | Strother SC, Anderson JR, Schaper KA, Sidtis JS, Rottenberg DA | 801979200 | Presentation |
| Commentary and opinion .1. Principal component analysis, variance partitioning, and functional connectivity | Journal of Cerebral Blood Flow & Metabolism | Strother SC, Kanno I, Rottenberg DA | 799300800 | Journal Article |
| Principal component analysis, variance partitioning and "functional connectivity" | Journal of Cerebral Blood Flow & Metabolism | Strother SC, Kanno I, Rottenberg DA | 788936400 | Journal Article |
| Principal component analysis and the scaled subprofile model compared to intersubject averaging and statistical parametric mapping .1. Functional connectivity of the human motor system studied with [O-15]water PET | Journal of Cerebral Blood Flow & Metabolism | Strother SC, Anderson JR, Schaper KA, Sidtis JS, Liow J-S, Woods RP, Rottenberg DA | 788936400 | Journal Article |
| Linear models of orthogonal subspaces and activated networks from functional activation PET studies of the human brain | Computational Imaging and Vision | Strother SC, Anderson JR, Schaper KA, Sidtis JS, Rottenberg DA | 788936400 | Book Chapter |
| Visualization of neural networks using saliency maps | IEEE International Conference on Neural Networks | Morch N, Kjems U, Hansen LK, Svarer C, Law I, Lautrup B, Strother SC, Rehm K | 788936400 | Journal Article |
| Massive weight sharing: A cure for extremely ill-posed problems | Proceedings of the workshop on supercomputing in brain research: From tomography to neural networks | Lautrup B, Hansen LK, Law I, Moerch N, Svarer C, Strother SC | 788936400 | Book Chapter |
| Improved resolution via 3D iterative reconstruction for PET volume imaging | IEEE Conference Record Nuclear Science Symposium and Medical Imaging Conference | Liow J-S, Strother SC, Rottenberg DA | 783493200 | Journal Article |
| Improved Resolution via 3D Iterative Reconstruction for PET Volume Imaging | JOURNAL OF NUCLEAR MEDICINE | Liow JS, Strother SC | 770788800 | Abstract |
| Noise and signal decoupling in maximum likelihood reconstructions and Metz filters for PET brain images | Physics in Medicine and Biology | Liow J-S, Strother SC | 757400400 | Journal Article |
| Display of merged multimodality brain images using interleaved pixels with independent color scales | Journal of Nuclear Medicine | Rehm K, Strother SC, Anderson JR, Schaper KA, Rottenberg DA | 757400400 | Journal Article |
| Quantitative comparisons of image registration techniques based on high resolution MRI of the brain | Journal of Computer Assisted Tomography | Strother SC, Anderson JR, Xu X-L, Liow J-S, Bonar DC, Rottenberg DA | 757400400 | Journal Article |
| Error-bounds for 5 image registration techniques based on high-resolution MRI | QUANTIFICATION OF BRAIN FUNCTION - TRACER KINETICS AND IMAGE ANALYSIS IN BRAIN PET INTERNATIONAL CONGRESS SERIES | Anderson JR, Strother SC, Xu XL, Bonar DC, Rottenberg DA | 754722000 | Presentation |
| Iterative algebraic reconstruction algorithms for emission computed tomography: A unified framework and its application to positron emission tomography | Medical Physics | Xu X-L, Liow J-S, Strother SC | 752130000 | Journal Article |
| Error-bounds for 5 registration techniques based on high-resolution MRI of the brain | JOURNAL OF NUCLEAR MEDICINE | Anderson JR, Strother SC, Xu XL, Bonar DC, Rottenberg DA | 739512000 | Abstract |
| Effect of Smear-Correcting Radial Arterial Blood Activity Curves on FDG-PET Measurements of Cerebral Metabolic-Rate for Glucose | JOURNAL OF NUCLEAR MEDICINE | Palmer BM, Strother SC, Rottenberg DA | 739512000 | Abstract |
| The convergence of object dependent resolution in maximum likelihood based tomographic image reconstruction | Physics in Medicine and Biology | Liow J-S, Strother SC | 725864400 | Journal Article |
| Graphical analysis of MR feature space for measurement of CSF, gray-matter and white-matter volumes | Journal of Computer Assisted Tomography | Bonar DC, Schaper KA, Anderson JR, Rottenberg DA, Strother SC | 725864400 | Journal Article |
| Effect of delay and dispersion correction of arterial blood activity curves on FDG-PET measurements of cerebral metabolic rates for glucose | Quantification of Brain Function: Tracer Kinetics and Image Analysis in Brain PET | Palmer BM, Strother SC, Rottenberg DA | 725864400 | Book Chapter |
| Error bounds for five registration techniques based on high resolution MRI | Quantification of Brain Function: Tracer Kinetics and Image Analysis in Brain PET | Anderson JR, Strother SC, Xiaoliang X, Bonar DC, Rottenberg DA | 725864400 | Book Chapter |
| Using principal component analysis to identify a disease independent pattern of cerebral metabolic activation: The reticular activating system? | Quantification of Brain Function: Tracer Kinetics and Image Analysis in Brain PET | Strother SC, Moeller JR, Sidtis JJ, Rottenberg DA | 725864400 | Book Chapter |
| A novel iterative reconstruction algorithm for emission computed tomography | IEEE International Conference on Acoustics, Speech, and Signal Processing | Xu XL, Liow J-S, Strother SC | 725864400 | Journal Article |
| EFFECT OF DELAY AND DISPERSION CORRECTION OF ARTERIAL BLOOD ACTIVITY CURVES ON FDG-PET MEASUREMENTS OF CEREBRAL METABOLIC-RATE FOR GLUCOSE | QUANTIFICATION OF BRAIN FUNCTION - TRACER KINETICS AND IMAGE ANALYSIS IN BRAIN PET INTERNATIONAL CONGRESS SERIES | PALMER BM, STROTHER SC, ROTTENBERG DA | 723186000 | Presentation |
| Performance of maximum likelihood based image reconstruction for quantitative imaging | IEEE Nuclear Science Symposium and Medical Imaging Conference | Liow J-S, Strother SC | 694242000 | Journal Article |
| A non-iterative linear algebraic algorithm for image reconstruction | IEEE Nuclear Science Symposium and Medical Imaging Conference | Xu X-L, Liow J-S, Strother SC | 694242000 | Journal Article |
| Noise and signal decoupling in maximum likelihood reconstructions and Metz filters for PET images | IEEE Nuclear Science Symposium and Medical Imaging Conference | Liow J-S, Strother SC | 694242000 | Journal Article |
| Practical tradeoffs between noise, quantitation, and number of iterations for maximum likelihood-based reconstructions | IEEE Transactions on Medical Imaging | Liow J-S, Strother SC | 691563600 | Journal Article |
| The metabolic landscape of cortico-basal ganglionic degeneration: regional asymmetries studied with positron emission tomography | Journal of Neurology, Neurosurgery & Psychiatry | Eidelberg D, Dhawan V, Moeller JR, Sidtis JJ, Ginos JZ, Strother SC, Cedarbaum J, Greene P, Fahn S, Powers JM, Rottenberg DA | 686289600 | Journal Article |
| A linear spatial correlation model, with applications to Positron Emission Tomography | Journal of the American Statistical Association | Worsley KJ, Evans AC, Strother SC, Tyler JL | 662706000 | Journal Article |
| Effects of percent thresholding on the extraction of (18F)fluorodeoxyglucose positron emission tomographic region-of-interest data | Journal of Cerebral Blood Flow & Metabolism | Rottenberg DA, Moeller JR, Strother SC, Sidtis JJ, Dhawan V | 662706000 | Journal Article |
| Abnormal cerebral glucose metabolism in long-term survivors of childhood acute lymphocytic leukemia | Annals of Neurology | Phillips PC, Moeller JR, Sidtis JJ, Dhawan V, Steinherz PG, Strother SC, Ginos JZ, Rottenberg DA | 662706000 | Journal Article |
| Absolute quantitation in neurological PET: Do we need it? | Journal of Cerebral Blood Flow & Metabolism | Strother SC, Liow J-S, Moeller JR, Sidtis JJ, Dhawan V, Rottenberg DA | 662706000 | Journal Article |
| A regional covariance approach to the analysis of functional patterns in positron emission tomographic data | Journal of Cerebral Blood Flow & Metabolism | Moeller JR, Strother SC | 662706000 | Journal Article |
| Performance of maximum likelihood based iterative image reconstruction for quantitative imaging | IEEE Engineering in Medicine and Biology Society | Strother SC, Liow J-S | 662706000 | Book Chapter |
| Measuring PET scanner sensitivity - relating countrates to image signal-to-noise ratios using noise equivalent counts | IEEE Transactions on Nuclear Science | Strother SC, Casey ME, Hoffman EJ | 640324800 | Journal Article |
| The metabolic anatomy of Parkinson's disease: Complementary [F-18]Fluorodeoxyglucose and [F-18]Fluorodopa positron emission tomographic studies | Movement Disorders | Eidelberg D, Moeller JR, Dhawan V, Sidtis JJ, Ginos JZ, Strother SC, Cedarbaum J, Greene P, Fahn S, Rottenberg DA | 631170000 | Journal Article |
| Practical tradeoffs between noise, resolution and quantitation, and number of iterations for maximum likelihood reconstructions | IEEE Nuclear Science Symposium | Liow J-S, Strother SC | 631170000 | Journal Article |
| In defense of quantitative PET techniques | Journal of Nuclear Medicine | Rottenberg DA, Strother SC, Moeller JR | 607410000 | Journal Article |
| Positron emission tomographic measurement of blood-to-brain and blood-to-tumor transport of Rb-82 . 2. Clinical-data and validation of technique | Physics in Medicine and Biology | Dhawan V, Jarden JO, Moeller JR, Strother SC, Rottenberg DA | 599634000 | Journal Article |
| The time course of steroid action on blood-to-brain and blood-to-tumor transport of [Rb-82]: a positron emission tomographic study | Annals of Neurology | Jarden JO, Dhawan V, Moeller JR, Strother SC, Rottenberg DA | 599634000 | Journal Article |
| Effect of selecting a fixed dephosphorylation rate on the estimation of rate constants and rCMRGlu from dynamic [F-18] fluorodeoxyglucose PET data | Journal of Nuclear Medicine | Dhawan V, Moeller JR, Strother SC, Evans AC, Rottenberg DA | 599634000 | Journal Article |
| Positron emission tomographic measurement of blood-to-brain and blood-to-tumor transport of RB-82 .1. Error analysis and computer-simulations | Physics in Medicine and Biology | Dhawan V, Poltorak A, Moeller JR, Jarden JO, Strother SC, Thaler H, Rottenberg DA | 599634000 | Journal Article |
| Effect of blood curve smearing on the accuracy of parameter estimates obtained for [Rb-82]/PET studies of blood-brain barrier permeability | Physics in Medicine and Biology | Dhawan V, Jarden JO, Strother SC, Rottenberg DA | 568011600 | Journal Article |
| Stability of regional cerebral glucose metabolism in the normal brain measured by positron emission tomography | Journal of Nuclear Medicine | Tyler JL, Strother SC, Zatorre RJ, Alivisatos B, Worsley KJ, Diskic M, Yamamoto YL | 568011600 | Journal Article |
| The metabolic anatomy of paraneoplastic cerebellar degeneration | Annals of Neurology | Anderson NE, Posner JB, Sidtis JJ, Moeller JR, Strother SC, Dhawan V, Rottenberg DA | 568011600 | Journal Article |
| The metabolic pathology of the AIDS dementia complex | Annals of Neurology | Rottenberg DA, Moeller JR, Strother SC, Sidtis JJ, Navia BA, Dhawan V, Ginos JZ, Price PW | 536475600 | Journal Article |
| Differences in cerebral blood flow and glucose utilization in vegetative versus locked-in patients | Annals of Neurology | Levy DE, Sidtis JJ, Rottenberg DA, Jarden JO, Strother SC, Dhawan V, Ginos JZ, Tramo MJ, Evans AC, Plum F | 536475600 | Journal Article |
| Scaled subprofile model: a statistical approach to the analysis of functional patterns in positron emission tomographic data | Journal of Cerebral Blood Flow & Metabolism | Moeller JR, Strother SC, Sidtis JJ, Rottenberg DA | 536475600 | Journal Article |
| Headholders for functional brain imaging | Journal of Cerebral Blood Flow & Metabolism | Strother SC, Perlmutter JS | 536475600 | Journal Article |
| [N-13] cisplatin PET to assess pharmacokinetics of intra-arterial versus intravenous chemotherapy for malignant brain tumors | Journal of Nuclear Medicine | Ginos JZ, Cooper AJL, Dhawan V, Lai JC, Strother SC, Alcock N, Rottenberg DA | 536475600 | Journal Article |
| Reduced cerebral glucose metabolism and increased brain capillary permeability following high-dose methotrexate chemotherapy: a positron emission tomographic study | Annals of Neurology | Phillips PC, Dhawan V, Strother SC, Sidtis JJ, Evans AC, Allen JC, Rottenberg DA | 536475600 | Journal Article |
| A technique to reject scattered radiation in PET transmission scans | International Workshop on Physics and Engineering of Computerized Multidimensional Imaging and Processing | Thompson CJ, Dagher A, Lunney DN, Strother SC, Evans AC | 504939600 | Book Chapter |
| Correcting positron emission tomography data for cerebral atrophy | Journal of Cerebral Blood Flow & Metabolism | Strother SC, Rottenberg DA | 504939600 | Journal Article |
| Sensitivity of positron detection for a pair of opposed detectors compared with ring scanners using image-reconstruction | Journal of Nuclear Medicine | Strother SC, Allard C | 504939600 | Journal Article |
| An inter-center comparison of region of interest and resolution effects for normal 18F-fluorodeoxyglucose studies with PET | Journal of Cerebral Blood Flow & Metabolism | Strother SC, Tyler JK, Peters T, Thompson C, Evans AC, Diksic M, Meyer E, Yamamoto YL, Feindel W | 473403600 | Journal Article |
| An improved approach for measurement of regional cerebral rate constants in the deoxyglucose method with positron emission tomography | Journal of Cerebral Blood Flow & Metabolism | Kato A, Diksic M, Yamamoto YL, Strother SC, Feindel W | 470725200 | Journal Article |
| A contrast-detail-noise approach to the study of display conditions | IEEE Computer Society | Strother SC, Peters TM | 410245200 | Journal Article |
| Application of spatial filtering to CT imagery | IEEE Computer Society | Peters TM, Strother SC | 383806800 | Journal Article |
| Analysing dose limited radiation imaging systems | New Zealand Medical Physics and Biomedical Engineering Journal | Peters TM, Strother SC | 347173200 | Journal Article |
| The Delta 2020 CT Scanner | New Zealand Medical Physics and Biomedical Engineering Journal | Strother SC | 252478800 | Journal Article |
Academic Appointments
- 2004–Present: Senior Scientist , Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
- 2004–Present: Professor , Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
- 2007–2010: Full Member, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
- 2007–2010: Member, Program in Neuroscience, University of Toronto, Toronto, Ontario, Canada
- 2008–Present: Core Member, Centre for Stroke Recovery
- 2011–Present: Associate Director, Baycrest Site, Cnetre for Stroke Recovery
Research Groups
- 2004–Present: Anita Oder, Research Assistant/Programmer, Integrating Predictive Modeling and PLS in a Java Framework
- 2008: Wayne Lee, Research Assistant, fMRI Processing
- 2005–2008: Wayne Lee, MBP masters student, Assessing the Efficacy of Preprocessing Choices: Intensity Normalisation as a Function of Task and Age
- 2005–2007: Mani Fazeli, MBP masters student, Assessing the Efficacy of Preprocessing Choices: Residual Motion Artifacts as a Function of Task and Age
- 2006–Present: Grigori Yourganov, IMS PhD student, Rotman Research Institute (Co-supervised with Dr. R. McIntosh)
- 2007–Present: Jennifer Evans, IMS PhD student, Hospital for Sick Children (Co-supervised with Dr. M. Taylor)
- 2007–Present: Chris Thomas, Postdoctoral Fellow
Reviewership
Committee
- 2002–Present: Chair, Data Format Working Group of Neuroinformatics Technology Initiative, NIH,
- 2006–Present: External Advisory Committee, Functional Bioinformatics Resource Network (fBIRN
Editorial Board
- 2003–Present: Human Brain Mapping, Associate Editor
- 2007–Present: Frontiers in NeuroInformatics, Review Editor
Research Projects
External
-
2007–2011:
Towards Clinical FMRI: Characterizing a Rapid, Multitask, fMRI Battery as a Function of Age
Collaborators: SC Strother, S Graham, C Grady, J WeenSponsors: CIHR, 240,000 (Cdn)
Research Grant -
2007–2010:
Memory and attention in people who experienced a single life-threatening event
Collaborators: Levine, B., Anderson, A.K., McKinnon, M., Moscovitch, M., Feinstein, A., Mayberg, H., Graham, S.I., Strother, S., and McIntosh, A.R.Sponsors: National Institutes of Mental Health, 731,652 (USD)
Research GrantR01 MH076067-02,(3 years) US$10,944 (Equipment).
-
2005–2008:
Network mechanisms underlying cognition and recovery of function in the human brain
Collaborators: AR McIntoshSponsors: Bridging Brain, Mind, and Behavior, James S. McDonnell Foundation, 4,200,000 (USD)
Research GrantLink: http://www.jsmf.org/
-
2005–2007:
fMRI Research via Database Mining, Management. Project 2: Optimizing fMRI Processing Pipelines
Collaborators: MS Gazzaniga, PhD, Dartmouth CollegeSponsors: National Institute of Mental Health, NIH, 1,500,000 (USD)
Research GrantCore-Project 1: J Van Horn; Project 2: SC Strother; Project 3: M D'Esposito
Project 2: US$200,000
Curriculum Vitae
Contact
The Rotman Research InstituteBaycrest
3560 Bathurst Street, 1058
Toronto, Ontario,
Canada M6A 2E1 Phone: 416 785 2500 x2956 Email: sstrother (at) rotman-baycrest.on.ca Fax: 416 785 2862
Baycrest is an academic health sciences centre fully affiliated with the University of Toronto
Privacy Statement | Disclaimer | © 2012 Baycrest. All Rights Reserved.