Email

Email .pdf (1.41 MB)

Journal Article

Reference (APA Format)

Balslev D., Nielsen F.A., Frutiger S.A., Sidtis J.J., Christiansen T.B., Svarer C., Strother S.C., Rottenberg D.A., Hansen L.K., Paulson O.B. & Law I. 2002. Cluster analysis of activity time-series in motor learning. Human Brain Mapping, 15, 135-145.

Title

Cluster analysis of activity time-series in motor learning

Journal Name

Human Brain Mapping

Abstract

Neuroimaging studies of learning focus on brain areas where the activity changes as a function of time. To circumvent the difficult problem of model selection, we used a data-driven analytic tool, cluster analysis, which extracts representative temporal and spatial patterns from the voxel-time series. The optimal number of clusters was chosen using a cross-validated likelihood method, which highlights the clustering pattern that generalizes best over the subjects. Data were acquired with PET at different time points during practice of a visuomotor task. The results from cluster analysis show practice-related activity in a fronto-parieto-cerebellar network, in agreement with previous studies of motor learning. These voxels were separated from a group of voxels showing an unspecific time-effect and another group of voxels, whose activation was an artifact from smoothing.

Volume

15

Year

2002

Pages

135-145

Authors

Balslev D., Nielsen F.A., Frutiger S.A., Sidtis J.J., Christiansen T.B., Svarer C., Strother S.C., Rottenberg D.A., Hansen L.K., Paulson O.B. & Law I.