Prefrontal cortex and episodic memory retrieval mode
Proceedings of the National Academy of Sciences of the United States of America
A multistudy analysis of positron emission tomography data identified threeright prefrontal and two left prefrontal cortical sites, as well as a region inthe anterior cingulate gyrus, where neuronal activity is correlated with themaintenance of episodic memory retrieval mode (REMO), a basic and necessarycondition of remembering past experiences. The right prefrontal sites were nearthe frontal pole [Brodmann's area (BA) 10], frontal operculum (BA 47/45), andlateral dorsal area (BA 8/9). The two left prefrontal sites were homotopicalwith the right frontal pole and opercular sites. The same kinds of REMO siteswere not observed in any other cerebral region. Many previous functionalneuroimaging studies of episodic memory retrieval have reported activations nearthe frontal REMO sites identified here, although their function has not beenclear. Many of these, too, probably have signaled their involvement in REMO. Wepropose that REMO activations largely if not entirely account for the frontalhemispheric asymmetry of retrieval as described by the original hemisphericencoding retrieval asymmetry model.
Lepage M., Ghaffar O., Nyberg L. & Tulving E.
Publisher: NATL ACAD SCIENCES, 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA Subject Category: Multidisciplinary Sciences IDS Number: 271ZA ISSN: 0027-8424