Quantification of Brain Function: Tracer Kinetics and Image Analysis in Brain PET
Effect of delay and dispersion correction of arterial blood activity curves on FDG-PET measurements of cerebral metabolic rates for glucose
Uemura K., Lassen N.A., Jones T. & Kanno I.
Elsevier Science Publishers B.V.
Amsterdam, The Netherlands
Quantitative measurements of regional cerebral metabolic rate for glucose (rCMR,,,) with FDG-PET require the acquisition of a tissue arterial blood activity curve (BAC), which is usually measured by radial arterial sampling. Although arterial sampling permits excellent quantitation of radioactivity, temporal smearing errors are unavoidable due to differences in the tracer's transit time and dispersion from the left ventricle to the carotid and radial arteries. In addition to this internal smearing, discrete arterial blood samples are usually taken with an automatic blood sampling system, which introduces significant external smearing into the measured radial arterial BAC [I].
Palmer B.M., Strother S.C. & Rottenberg D.A.