Morris Freedman

Morris Freedman, MD, FRCP(C)

Head Division of Neurology, Baycrest Health Sciences

Professor Faculty of Medicine (Neurology), University of Toronto

Scientist Rotman Research Institute, Baycrest Health Sciences

Medical Director Cognition & Behaviour, Baycrest Health Sciences

Research Focus

My research is aimed at improving our understanding of the mechanisms underlying cognitive impairment due to Alzheimer’s disease and frontotemporal dementia.  A major focus is on the study of social cognition in these disorders. A second focus is on the development of cognitive assessment procedures in dementia.  My colleagues and I have written a book on clock drawing that contains a large set of normative data and have developed a mental status examination, called the Behavioural Neurology Assessment, that is suitable for use by physicians in the office setting.

This research will have implications for future studies in Alzheimer's disease related to determining the underlying causes, the development of refined diagnostic criteria, and treatment.

Publications

Title Source (Journal/Book/Conference) Authors/Presenters Published On Type
Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI) J Alzheimer’s Disease Montero-Odasso M, Pieruccini-Faria F, Bartha R, Black S, Corbett D, Finger E, Freedman M, Greenberg B, Grimes D, Hegele R, Hudson C, Kleisteiver P, Lang A, Masselis M, McLaughlin P, Munoz D, Strother S, Swartz R, Simons S, Tartaglia C, Zinman L, Strong M, ONDRI Investigators, McIIroy W 1503633600 Journal Article
White matter disruption and connected speech in non-fluent and semantic variants of primary progressive aphasia. Dementia and Geriatric Cognitive Disorders Extra Marcotte K, Graham NL, Fraser KC, Meltzer JA, Tang-Wai D, Chow TW, Freedman M, Leonard C, Black SE, Rochon E 1488430800 Journal Article
The Ontario Neurodegenerative Disease Research Initiative (ONDRI) Canadian Journal of Neurological Sciences Farhan SMK, Bartha R, Black SE, Corbett D, Finger E, Freedman M, Greenberg B, Grimes DA, Hegele RA, Hudson C, Kleinstiver PW, Lang AE, Masellis M, McIlroy WE, McLaughlin PM, Montero-Odasso M, Munoz DG, Munoz DP, Strother S, Swartz RH, Symons S, Tartaglia MC, Zinman L, and Strong MJ 1488344400 Journal Article
Behavioral and neuroimaging changes after naming therapy for semantic variant PPA Neuropsychologia Jokel R, Kieler A, Anderson ND, Black SE, Rochon E, Freedman M, Tang-Wai D, Graham S 1473307200 Journal Article
Mind-matter interactions and the frontal lobes of the brain: A novel neurobiological model of psi inhibition Explore: The Journal of Science and Healing Freedman M, Alain C, Black S, Ryan J, Chen R, Cusimano M, Whitehouse P, Jeffers S, Strother SC, Vallesi A, Gao F, Holmes M, Roseborough A, Binns M 1466827200 Journal Article
Theory of Mind and Recognition of Facial Emotion in Dementia Challenge to Current Concepts ALZHEIMER DISEASE & ASSOCIATED DISORDERS Freedman M, Binns MA, Black SE, Murphy C, Stuss DT 1366689600 Journal Article
Object Alternation: A Novel Probe of Medial Frontal Function in Frontotemporal Dementia. Alzheimer Disease & Associated Disorders Freedman M, Binns MA, Black SE, Levine B, Miller BL, Ramirez J, Szilagy G, Scott C, McNeely A, Stuss DT 1366257600 Journal Article
Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias Clinical Phenemenology of the Frontotemporal Dementias Henri-Bhargava A and Freedman M 1366257600 Book Chapter
Visiospatial Function in Behavioural Neurology and Neuropsychiatry Merims D and Freedman M 1366257600 Book Chapter
Determinants of survival in autopsy-confirmed patients with behavioral variant frontotemporal dementia (bvFTD) Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Xie S, van Swieten JC, Seelaar H, Dopper EGP, Onyike CU, Hillis A, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin K, Johnson JK, Gorno-Tempini ML, Rosen H, Neuhaus J, Latham C, Lee AS, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor M, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow T, Manes F, Grafman J, Cappa SF, Freedman M, Miller BL, Grossman M 1365652800 Abstract
Neurology in Canada: History of the Canadian Neurological Society Neurology Murray TJ, Freedman M, Stoessl JA 1358830800 Journal Article
Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome. Alzheimer's Research & Therapy Lam B, Masellis M, Freedman M, Stuss DT, Black SE 1357707600 Journal Article
Abnormal network connectivity in frontotemporal dementia: Evidence for prefrontal isolation Cortex Farb NA, Grady CL, Strother S, Tang-Wai DF, Masellis M, Black S, Freedman M, Pollock BG, Campbell KL, Hasher L, Chow TW 1348459200 Journal Article
Clomipramine in the treatment of compulsive behavior in frontotemporal dementia: A case series Alzheimer Disease & Associated Disorders Furlan JC, Henri-Bhargava A, Freedman M 1344744000 Journal Article
Theory of mind and recognition of facial emotion in dementia. Challenge to current concepts. Alzheimer Disease and Associated Disorders Freedman M, Binns MA, Black SE, Murphy C, Stuss DT 1338523200 Journal Article
An [11C]SB-13 PET study correlating neuropsychiatric symptoms in Alzheimer’s disease with regional beta-amyloid burden Psychiatry Research: Neuroimaging Kaye ED, Honjo K, Petrovic-Poljak A, Reekum R, Streiner DL, Wilson AA, Black SE, Freedman M, Rusjan P, Houle S, Chow TW, Verhoeff NPLG 1325307600 Journal Article
Theory of Mind in Parkinson's Disease Journal of Neurological Sciences Freedman M, Stuss DT 1321333200 Journal Article
Theory of Mind in Parkinson’s Disease Journal of the Neurological Sciences Freedman M, Stuss DT 1321333200 Journal Article
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia Brain Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EGP, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Latham C, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer J, Rossor M, Warren NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, and Miller BL 1317873600 Journal Article
Predictors of Patient Self-Ratings of Quality of Life in Alzheimer Disease: Cross-Sectional Results From the Canadian Alzheimer's Disease Quality of Life Study American Journal of Geriatric Psychiatry Naglie G, Hogan D, Krahn M, Beattie BL, Black SE, MacKnight C, Freedman M, Patterson C, Borrie M, Bergman H, Byszewski A, Streiner D, Irvine J, Ritvo P, Comrie J, Kowgier M, Tomlinson G 1314158400 Journal Article
An Open-Label Study of the Short-Term Effects of Memantine on FDG-PET in Frontotemporal Dementia Neuropsychiatric Disease and Treatment Chow TW, Graff-Guerrero A, Verhoeff NPG, Binns MA, Tang-Wai DF, Freedman M, Masellis M, Black SE, Wilson AA, Houle S, Pollock BG 1310184000 Journal Article
Visual rating versus volumetry to detect frontotemporal dementia Dementia and Geriatric Cognitive Disorders Chow TW, Gao F, Links KA, Ween JE, Tang-Wai DF, Ramirez J, Scott CJM, Freedman M, Stuss DT, Black SE 1306814400 Journal Article
Comparative utility of linear, area and volumetric measures in detecting brain changes in FTD in correlation with cognitive performance 5th International Conference on Frontotemporal Dementia Gao FQ, Deshpande N, Ramierez J, Van Gaal S, Chow TW, Freedman M, Behl P, Black SE 1305259200 Presentation
Amyloid imaging with [11C]SB-13 PET: a test-retest reliability study 36th Annual Harvery Stancer Research Day Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black S 1303963200 Presentation
Prolactin response to Citalopram challenge predicts behavioural improvement in Frontotemporal Dementia INTERNATIONAL PSYCHOGERIATRICS Herrmann N, Black SE, Chow TW, Freedman M, Lanctôt KL 1303963200 Abstract
Neuroplasticity in dementia following language intervention: Illusion or possibility? Alzheimer's & Dementia Jokel R, Anderson N, Black S, Rochon E, Freedman M, Chow T, Tang-Wai D 1303617600 Abstract
Sensitivity of Diagnostic Criteria in Autopsy-Confirmed Patients with Behavioral Variant Frontotemporal Dementia (bvFTD): First Report of the International bvFTD Criteria Consortium NEUROLOGY Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Van Swieten JC, Seelaar H, Dopper EGP, Onyike CU, Hillis A, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin K, Johnson JK, Tempini MLG, Rosen H, Neuhaus J, Latham C, Lee AS, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor M, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Warren JD, Fox NC, Grossman M, Miller BL 1302667200 Abstract
Sensitivity of Diagnostic Criteria in Autopsy-Confirmed Patients with Behavioral Variant Frontotemporal Dementia (bvFTD): First Report of the International bvFTD Criteria Consortium Neurology American Academy of Neurology Rascovsky K, Hodges J, Knopman D, Chow TW, Manes F, Grafman J, Cappa S, Freedman M, Warren J, Fox N, Grossman M, Miller B 1302580800 Abstract
Treatment of Behavioural and Psychological Symptoms of Dementia in Frontotemporal Dementia with Citalopram AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY Herrmann N, Chow TW, Black SE, Freedman M, Lanctot KL 1300680000 Abstract
Visual rating vs. volumetry to detect frontotemporal dementia. Dementia and Geriatric Cognitive Disorders Chow TW, Gao F, Links KA, Ween JE, Tang-Wai DF, Ramirez J, Scott CJM, Freedman M, Stuss DT, Black SE 1298955600 Journal Article
Normal-pressure hydrocephalus: Is there a genetic predisposition? Canadian Journal of Neurological Sciences Cusimano MD, Rewilak D, Stuss DT, Barrera-Martinez JC, Salehi F, Freedman M 1298955600 Journal Article
Neuropsychological functioning in PLS: a comparison with ALS. Canadian Journal of Neurological Sciences Grace GM, Orange JB, Rowe A, Findlater K, Freedman M, Strong MJ 1293858000 Journal Article
Delaying the onset of Alzheimer disease: bilingualism as a form of cognitive reserve. Neurology Craik FI, Bialystok E, Freedman M 1289278800 Journal Article
Prevalence of primitive reflexes and parkinsonian signs in dementia Canadian Journal of Neurological Sciences Links KA, Merims D, Binns MA, Freedman M, Chow TW 1283313600 Journal Article
Occupation attributes relate to location of atrophy in frontotemporal lobar degeneration Neuropsychologia Spreng RN, Rosen H, Strother S, Chow TW, Diehl-Schmid J, Freedman M, Graff-Radford N, Hodges J, Lipton A, Mendez M, Morelli S, Black SE, Miller BL, Levine B 1283140800 Journal Article
Predictors of family caregiver ratings of patient quality of life in Alzheimer disease: Cross-sectional results from the Canadian Alzheimer’s Disease Quality of Life Study American Journal of Geriatric Psychiatry Naglie G, Hogan DB, Krahn M, Black SE, Beattie BL, Patterson C, MacKnight C, Freedman M, Borrie M, Byszewski A, Bergman H, Streiner D, Irvine J, Ritvo P, Comrie J, Kowgier M, Tomlinson G 1280635200 Journal Article
Predictors of patient self-ratings of quality of life in Alzheimer's Disease: Cross-sectional results from the Canadian Alzheimer's Disease Quality of Life (CADQOL) Study American Journal of Geriatric Psychiatry Naglie G, Hogan DB, Krahn M, Beattie BL, Black SE, MacKnight C, Freedman M, Patterson C, Borrie M, Bergman H, Byszewski A, Streiner D, Irvine J, Ritvo P, Comrie J, Kowgier M, Tomlinson G 1280635200 Journal Article
The effect of memantine on FDG-PET imaging in frontotemporal dementia Alzheimer’s Association International Conference on Alzheimer’s Disease Chow TW, Graff-Guerrero A, Freedman M, Tang-Wai D, Black SE, Pollock BG 1278734400 Presentation
Amyloid Imaging with [11C]SB-13 PET: A Test-Retest Reliability Study Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black S 1278734400 Presentation
Amyloid imaging with [11C]SB-13 PET: A test-retest reliability study ALZHEIMER'S & DEMENTIA Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black SE 1278734400 Abstract
Correlating neuropsychiatric symptoms with cerebral beta-amyloid load in mild Alzheimer's disease using [11C]SB-13 PET Kaye ED, Honjo K, Petrovic-Poljak A, van Reekum R, Streiner DL, Wilson A, Black SE, Freedman M, Rusjan P, Houle S, Verhoeff NPLG 1276747200 Presentation
Pre- and Post-Memantine FDG-PET Imaging in Frontotemporal Dementia NEUROLOGY Chow TW, Graff-Guerrero A, Freedman M, Tang-Wai D, Black SE, Pollock BG 1267419600 Abstract
Frontotemporal dementia and pharmacologic interventions Journal of Neuropsychiatry and Clinical Neurosciences Kaye ED, Petrovic-Poljak A, Verhoeff NP, Freedman M 1265000400 Journal Article
Progressive cognitive decline in a patient with isolated chronic neurosarcoidosis. The neurologist Oh J, Stokes K, Tyndel F, Freedman M 1262322000 Journal Article
Correlating neuropsychiatric symptoms with regional Beta-Amyloid load in the Alzheimer’s Disease brain using [11C]SB-13 PET Kaye E, Honjo K, Petrovic-Poljak A, van Reekum R, Streiner D, Wilson A, Black S, Freedman M, Rusjan P, Houle S, Verhoeff P 1258088400 Presentation
Does Beta-Amyloid correlate with neuropsychiatric symptoms in mild Alzheimer’s Disease? Kaye E, Honjo K, Petrovic-Poljak A, van Reekum R, Streiner D, Wilson A, Black S, Freedman M, Rusjan P, Houle S, Verhoeff P 1258088400 Presentation
Prevalence of primitive reflexes and Parkinsonism among patients with dementia Canadian Conference on Dementia Links K, Merims D, Binns M, Freedman M, Chow TW 1254456000 Presentation
Predictors of quality of life in family caregivers of person’s with Alzheimer's Disease: Cross-sectional results from the Canadian Alzheimer’s Disease Quality of Life (CADQOL) study CANADIAN JOURNAL OF GERIATRICS Naglie G, Borrie M, Black S, Beattie BL, Krahn M, Irvine J, Hogan D, Bergman H, Macknight C, Patterson C, Byszewski A, Freedman M, Streiner D, Ritvo P, Comrie J, Kowgier M, Tomlinson G 1254369600 Abstract
Pre-and post-memantine FDG-PET imaging in frontotemporal dementia 5th Canadian Conference on Dementia Chow TW, Binns MA, Freedman M, Pollock BG, Verhoeff NP, Graff-Guerrero A 1254369600 Presentation
Amyloid Imaging with [11C]SB-13 PET: A Test-Retest Reliability Study CANADIAN JOURNAL OF GERIATRICS Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black S 1254369600 Abstract
Pre- and post-memantine FDG-PET imaging in frontotemporal dementia 5th Canadian Conference on Dementia Chow TW, Binns MA, Freedman M, Pollock B, Verhoeff NPLG, Graff-Guerrero A 1254369600 Presentation
Apathy is not associated with basal ganglia atrophy in frontotemporal dementia American Journal of Geriatric Psychiatry Links KA, Chow TW, Binns M, Freedman M, Stuss DT, Scott CJ, Ramirez J, Black SE 1251777600 Journal Article
Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type Archives of Neurology Chow TW, Binns MA, Cummings JL, Lam I, Black SE, Miller BL, Freedman M, Stuss DT, van Reekum R 1248148800 Journal Article
Prevalence of Primitive Reflexes and Parkinsonism Among Patients with Dementia UNIVERSITY OF TORONTO DEPARTMENT OF PSYCHIATRY Links K, Merims D, Binns M, Freedman M, Chow TW 1246161600 Abstract
Amyloid imaging with [11C]SB-13 PET: a test-retest reliability study 35th Annual Harvery Stancer Research Day Verhoeff NPLG, Honjo K, Kaye ED, Petrovic-Poljak A, Wilson AA, Rusjan P, Houle S, van Reekum R, Freedman M, Black S 1245902400 Presentation
Correlating neuropsychiatric symptoms with regional beta-amyloid load in the Alzheimer’s disease brain using [11C]SB-13 PET UNIVERSITY OF TORONTO DEPARTMENT OF PSYCHIATRY Kaye ED, Honjo K, Petrovic-Poljak A, Van Reekum R, Streiner D, Wilson AA, Black SE, Freedman M, Rusjan P, Houle S, Verhoeff NPLG 1245902400 Abstract
Cerebral haemodynamic changes accompanying cognitive impairment in primary lateral sclerosis Amyotrophic Lateral Sclerosis Murphy MJ, Grace GM, Tartaglia MC, Orange JB, Chen XG, Rowe A, Findlater K, Kozak RI, Freedman M, Strong MJ, Lee TY 1244779200 Journal Article
Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis Strong MJ, Grace GM, Freedman M, Lomen-Hoerth C, Woolley S, Goldstein LH, Murphy J, Shoesmith C, Rosenfeld J, Leigh PN, Bruijn L, Ince P, Figlewicz D 1243828800 Journal Article
Predictors of quality of life in dementia caregivers JOURNAL OF THE AMERICAN GERIATRICS SOCIETY Naglie G, Borrie M, Black S, Beattie B, Krahn M, Irvine J, Hogan D, Bergman H, MacKnight C, Patterson C, Byszewski A, Freedman M, Streiner D, Ritvo P, Comrie J, Kowgier M, Tomlinson G 1240977600 Abstract
Correlating neuropsychiatric symptoms with regional beta-amyloid load in the Alzheimer’s disease brain using [11C]SB-13 PET CANADIAN JOURNAL OF GERIATRICS Kaye ED, Honjo K, Petrovic-Poljak A, Van Reekum R, Streiner D, Wilson AA, Black SE, Freedman M, Rusjan P, Houle S, Verhoeff NPLG 1240632000 Abstract
Research challenges in a study assessing driving fitness in persons with mild cognitive impairment (MCI) and mild dementia CANADIAN JOURNAL OF GERIATRICS Naglie G, Rapoport M, Man-Son-Hing M, Marshall S, Korner-Bitensky N, Black S, Herrmann N, Tang-Wai D, Tuokko H, Freedman M, Gélinas I, Tomlinson G 1240459200 Abstract
Pre- and post-memantine FDG-PET imaging in frontotemporal dementia AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY Chow T, Binns M, Dombrower H, Freedman M, Verhoeff P, Pollock BG 1236229200 Abstract
Pre- and post-memantine FDG-PET imaging in frontotemporal dementia. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY Chow TW, Binns MA, Freedman M, Pollock B, Verhoeff NPLG, Graff-Guerrero A 1236229200 Abstract
Treatment of behavioral and psychological symptoms of dementia in Frontotemporal Dementia with Citalopram AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY Herrmann N, Black SE, Chow TW, Freedman M, Lanctot KL 1236229200 Abstract
Predictors of quality of life in dementia caregivers JOURNAL OF THE AMERICAN GERIATRICS SOCIETY Naglie G, Borrie M, Black S, Beattie B, Krahn M, Irvine J, Hogan D, Bergman H, MacKnight C, Patterson C, Byszewski A, Freedman M, Streiner D, Ritvo P, Comrie J, Kowgier M, Tomlinson G 1235883600 Abstract
Autobiographical memory and patterns of brain atrophy in frontotemporal lobar degeneration Journal of Cognitive Neuroscience McKinnon MC, Nica EI, Sengdy P, Kovacevic N, Moscovitch M, Freedman M, Miller BL, Black SE, Levine B 1222833600 Journal Article
Overlap in frontotemporal atrophy between normal aging and patients with frontotemporal dementias Alzheimer Disease & Associated Disorders Chow TW, Binns MA, Freedman M, Stuss DT, Ramirez J, Scott CJM, Black SE 1222833600 Journal Article
Apathy is associated with harmful behaviors in frontotemporal dementia and Alzheimer’s disease Dementia and Geriatric Cognitive Disorders Chow TW, Binns MA, van Reekum R, Freedman M, Cummings JL, Lam I, Black SE, Miller BL 1220414400 Abstract
Occupation attributes relate to laterality of atrophy in frontotemporal lobar degeneration Dementia and Geriatric Cognitive Disorders Spreng RN, Rosen HJ, Black SE, Chow TW, Diehl-Schmid J, Freedman M, Graff-Radford NR, Hodges JR, Lipton AM, Mendez MF, Morelli SA, Miller BL, Levine B 1220414400 Abstract
Involvement of ApoE e4 and H63D in sporadic Alzheimer's disease in a folate-supplemented Ontario population Journal of Alzheimer's Disease Percy M, Moalem S, Garcia A, Somerville MJ, Hicks M, Andrews D, Azad A, Schwarz P, Beheshti Zavareh R, Birkan R, Choo C, Chow V, Dhaliwal S, Duda V, Kupferschmidt AL, Lam K, Lightman D, Machalek K, Mar W, Nguyen F, Rytwinski PJ, Svara E, Tran M, Yeung L, Zanibbi K, Zener R, Ziraldo M, Freedman M 1220241600 Journal Article
Cognitive and behavioural impairment in Parkinson's disease International Review of Psychiatry Merims D, Freedman M 1219982400 Journal Article
Apathy in Dementia: Clinical and sociodemographic correlates Journal of Neuropsychiatry & Clinical Neurosciences Clarke DE, van Reekum R, Simard M, Streiner DL, Freedman M, Conn D 1217563200 Journal Article
Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophy Dementia and Geriatric Cognitive Disorders Chow TW, Izenberg A, Binns MA, Freedman M, Stuss DT, Scott CJM, Ramirez J, Black SE 1215662400 Journal Article
Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia Canadian Medical Association Journal Chertkow H, Massoud F, Nasreddine Z, Belleville S, Joanette Y, Bocti C, Drolet V, Kirk J, Freedman M, Bergman H 1210046400 Journal Article
Depressive symptoms and functional status predict quality of life in patients with Alzheimer's disease JOURNAL OF THE AMERICAN GERIATRICS SOCIETY Naglie A, Comrie J, Beattie L, Bergman H, Black S, Borrie M, Byszewski A, Freedman M, Hogan D, Irvine J, Krahn M, MacKnight C, Patterson C, Ritvo P, Streiner D, Kowgier M, Tomlinson G 1209614400 Abstract
Depressive symptoms and functional status predict quality of life in patients with Alzheimer's Disease Journal of the American Geriatrics Society Naglie G, Comrie J, Beattie L, Bergman H, Black S, Borrie M, Byszewski A, Freedman M, Hogan D, Irvine J, Krahn M, MacKnight C, Patterson C, Ritvo P, Streiner D, Kowgier M, Tomlinson G 1207713600 Journal Article
Episodic memory and regional atrophy in frontotemporal lobar degeneration Neuropsychologia Söderlund H, Black SE, Miller BL, Freedman M,Levine B 1199163600 Journal Article
Office Evaluation of Dementia Neurology Update Freedman M 1199163600 Presentation
Dementia: Putting the 2007 Recommendations into Practice Geriatric Refresher Day Freedman M 1199163600 Presentation
Differentiating the dementias: A road map to the history, mental state and neurological exam Geriatric Refresher Day Freedman M 1199163600 Presentation
Mild cognitive impairment and cognitive impairment, no dementia: Part B, therapy Alzheimer's & Dementia Massoud F, Belleville S, Bergman H, Kirk J, Chertkow H, Nasreddine Z, Joanette Y, Freedman M 1191211200 Journal Article
Patient and caregiver quality of life in Alzheimer's disease in relation to cognitive severity JOURNAL OF THE AMERICAN GERIATRICS SOCIETY Naglie G, Comrie J, Beattie L, Bergman H, Black S, Borrie M, Byszewski A, Freedman M, Hogan D, Irvine J, Krahn M, MacKnight C, Patterson C, Ritvo P, Streiner D, Kowgier M, Tomlinson G 1178078400 Abstract
Cognitive decline and human (Homo sapiens) aging: An investigation using a comparative neuropsychological approach Journal of Comparative Psychology Boutet I, Milgram NW, Freedman M 1176091200 Journal Article
Frontotemporal dementia: recommendations for therapeutic studies, designs, and approaches Canadian Journal of Neurological Sciences Freedman M 1172725200 Journal Article
Apathy in dementia: An examination of the psychometric properties of the apathy evaluation scale Journal of Neuropsychiatry & Clinical Neurosciences Clarke D, van Reekum R, Simard M, Streiner D, Freedman M, Conn D 1167627600 Journal Article
Associative (prosop)agnosia without (apparent) perceptual deficits: a case-study Neuropsychologia Anaki D, Kaufman Y, Freedman M, Moscovitch M 1167627600 Journal Article
Cognitive decline in Alzheimer disease: Impact of spirituality, religiosity, and QOL. Neurology Kaufman Y, Anaki D, Binns M, Freedman M 1167627600 Journal Article
Bilingualism as a protection against the onset of symptoms of dementia Neuropsychologia Bialystok E, Craik FI, Freedman M 1167627600 Journal Article
Adverse drug events in cognitively impaired elderly patients Dementia and Geriatric Cognitive Disorders Ganjavi H, Herrmann N, Rochon PA, Sharma P, Lee M, Cassel D, Freedman M, Black SE, Lanctot KL 1167627600 Journal Article
The clock test Fourth Canadian Colloquium on Dementia Freedman M 1167627600 Presentation
Office Evaluation of Dementia Fourth Canadian Colloquium on Dementia Freedman M 1167627600 Presentation
Attention decline in a cohort of older persons with normal cognitive function at baseline: relationship to changes in homocysteine levels BRAIN AND COGNITION Garcia A, Zanibbi K, Day A, Freedman M 1159675200 Abstract
Iatrogenic apathy in frontotemporal dementia University of California at San Francisco Chow TW, Binns MA, Pataky CE, Huang D, Yeo T, Cummings JL, Lam I, Black SE, Kelly S, Miller BL, Freedman M 1157515200 Presentation
Left orbitofrontal atrophy correlates with disinhibition and apathy in frontotemporal degeneration ALZHEIMER’S & DEMENTIA Chow TW, Binns MA, Freedman M, Stuss DT, Ramirez J, Verhoeff NPLG, Black SE 1153022400 Abstract
The diagnostic utility of regional atrophy in frontotemporal degeneration ALZHEIMER’S & DEMENTIA Chow TW, Binns MA, Freedman M, Stuss DT, Ramirez J, Black SE 1150344000 Abstract
Early stages of FTD show subcortical atrophy NEUROLOGY Izenberg AE, Chow TW, Binns MA, Freedman M, Stuss DT, Ramirez J, Black SE 1144209600 Abstract
Early stages of FTD show subcortical atrophy 58th Annual Meeting of the American-Academy-of-Neurology Izenberg AE, Chow T, Binns M, Freedman M, Stuss D, Ramirez J, Black S 1142312400 Presentation
Utility-based quality of life measures in Alzheimer's disease. Quality of Life Research Naglie G, Tomlinson G, Tansey C, Irvine J, Ritvo P, Black SE, Freedman M, Silberfeld M, Krahn M 1136091600 Journal Article
Progress in clinical neurosciences: Canadian guidelines for the development of antidementia therapies: a conceptual summary Canadian Journal of Neurological Sciences Feldman HH, Gauthier S, Chertkow H, Conn DK, Freedman M, Chris M, 1136091600 Journal Article
Cognitive Enhancers for dementia and Mild Cognitive Impairment: where are we Dr. Ira Pollock Clinic Day: Clinical Issues in Geriatric and Long-Term Care Freedman M 1136091600 Presentation
Dementia with Lewy Bodies: Diagnosis, cognitive assessment and treatment Neurology Update Freedman M 1136091600 Presentation
Streifler Lecture: Frontotemporal Dementia 13th Tel-Aviv University Alzheimer's Disease Conference Freedman M 1136091600 Presentation
Clinical phenomenology and treatment of frontotemporal dementia. Neurology Update Freedman M 1136091600 Presentation
Behaviour in FTD syndromes 2nd International ALS Research Workshop Freedman M 1136091600 Presentation
Cognitive enhancers for dementia and MCI Geriatric Rounds Freedman M 1136091600 Presentation
The effects of spirituality and religiosity on the rate of cognitive decline and quality of life in Alzheimer's disease NEUROLOGY Kaufman Y, Anaki D, Binns MA, Freedman M 1113278400 Abstract
Learning and memory as a function of age in Down syndrome: A study using animal-based tasks PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Nelson L, Johnson JX, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E 1109653200 Presentation
Hippocampal complex contribution to retention and retrieval of recent and remote episodic and semantic memories: evidence from behavioral and neuroimaging studies of healthy and brain-damaged people Dynamic Cognitive Processes Moscovitch M, Westmacott R, Gilboa A, Addis DR, Rosenbaum RS, Viskontas I, Priselac S, Svoboda E, Ziegler M, Black SE, Gao F, Grady CL, Freedman M, Köhler S, Leach L, Levine B, McAndrews MP, Nadel L, Proulx G, Richards B, Ryan L, Stokes K, Winocur G 1104555600 Book Chapter
The behavioural neurology assessment Canadian Journal of Neurological Sciences Darvesh S, Leach L, Black SE, Kaplan E, Freedman M 1104555600 Journal Article
Age-associated cognitive deficits in humans and dogs: a comparative neuropsychological approach. Progress in Neuro-Psychopharmacology & Biological Psychiatry Boutet I, Ryan M, Kulaga V, McShane C, Christie LA, Freedman M, Milgram NW 1104555600 Journal Article
Reduced serotonin 1a receptor binding potential and abnormal oral behaviors in frontotemporal degeneration Neurology Chow TW, Verhoeff NPLG, Takeshita S, Freedman M, Black S, Wilson A, Hussey D, Houle S, Meyer J 1104555600 Abstract
Alzheimer's and related diseases: What's new? CCSAM/ISSAM North American Congress on The Aging Male Freedman M 1104555600 Presentation
Needs assessment 40th Annual Canadian Congress of Neurological Sciences Meeting Freedman M 1104555600 Presentation
Dementia with Lewy Bodies. Sixth Annual Gerald Zetter Memorial Lecture Freedman M 1104555600 Presentation
Clock drawing in normal aging and dementia Lecture to Alberta Association on Gerontology Freedman M 1104555600 Presentation
The Baycrest Dementia Scale: The Behavioural Neurology Assessment) and its Application - A Hands-On Workshop Association of Ontario Neurologists Neurology Update Freedman M 1104555600 Presentation
Frontotemporal Dementia: Current Concepts for the Clinician Medical Grand Rounds Freedman M 1104555600 Presentation
Frontotemporal lobar degeneration Third Canadian Colloquium on Dementia Freedman M 1104555600 Presentation
Clock drawing in the assessment of cognitive function Third Canadian Colloquium on Dementia Freedman M 1104555600 Presentation
Cognitive and behavioral changes in the Parkinson-plus syndromes. Advances in Neurology Cohen S, Freedman M 1104555600 Journal Article
Rate of cognitive decline in Alzheimer’s disease and spirituality/religiosity ANNALS OF NEUROLOGY Kaufman Y, Anaki D, Binns MA, Freedman M 1096862400 Abstract
Depression in frontotemporal dementia is associated with decreased left temporal lobe 5HT1a receptor density ANNALS OF NEUROLOGY Chow TW, Verhoeff NPLG, Takeshita S, St Jacques PL, Freedman M, Black SE, Wilson A, Hussey D, Houle S, Meyer J 1096862400 Abstract
Rate of cognitive decline in Alzheimers disease and spirituality/religiosity ANNALS OF NEUROLOGY Kaufman Y, Anaki D, Binns MA, Freedman M 1096689600 Abstract
Validity of utility-based quality of life measures in Alzheimer's disease GERONTOLOGIST Naglie G, Black S, Irvine J, Krahn M, Taney C, Silberfeld M, Freedman M, Ritvo P, Tomlinson G 1096603200 Abstract
Reduced serotonin 1a receptors in depressed frontotemporal lobar degeneration subjects Symposium for Frontotemporal Dementia Chow TW, Verhoeff NPLG, Takeshita S, Freedman M, Black SE, Wilson A, Hussey D, Houle S, Meyer J 1089691200 Presentation
Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: Systematic review British Medical Journal Lee PE, Gill SS, Freedman M, Bronskill SE, Hillmer MP, Rochon PA 1089432000 Journal Article
Recognition of the non-Alzheimer's dementias: Highlights from the University of Toronto behavioural neurology clinic day Geriatrics and Aging Gladstone DJ, Zinman L, Burton J, Casaubon L, Chan D, Cashman N, Black SE, Freedman M 1072933200 Journal Article
The contribution of autobiographical significance to semantic memory: evidence from Alzheimer's disease, semantic dementia, and amnesia Neuropsychologia Westmacott R, Black SE, Freedman M, Moscovitch M 1072933200 Journal Article
Temporally graded semantic memory loss in Alzheimer's disease: cross-sectional and longitudinal studies Cognitive Neuropsychology Westmacott R, Freedman M, Black SE, Stokes KA, Moscovitch M 1072933200 Journal Article
Increases in homocysteine are related to worsening of stroop scores in healthy elderly persons: a prospective follow-up study Journals of Gerontology Series A: Biological Sciences and Medical Sciences Garcia A, Haron Y, Pulman K, Hua L, Freedman M 1072933200 Journal Article
Cobalamin reduces homocysteine in older adults on folic acid-fortified diet: a pilot, double-blind, randomized, placebo-controlled trial. Journal of the American Geriatrics Society Garcia A, Pulman K, Zanibbi K, Day A, Galaraneau L, Freedman M 1072933200 Journal Article
Metabolic markers of cobalamin deficiency and cognitive function in normal older adults. Journal of the American Geriatrics Society Garcia AA, Haron Y, Evans LR, Smith MG, Freedman M, Roman GC 1072933200 Journal Article
An evaluation of the role of needs assessments, planning committees and experts in continuing education Geriatrics Today Holroyd-Leduc JM, Liu BA, Freedman M, Mehta R, Sibbald RG, Izukawa TA 1072933200 Journal Article
The Baycrest Dementia Scale (The Behavioural Neurology Assessment) and its Application – A Hands-on Workshop. Association of Ontario Neurologists Neurology Update Freedman M 1072933200 Presentation
Effects of frontal lobe lesions on intentionality and random physical phenomena Journal of Scientific Exploration Freedman M, Jeffers S, Saeger K, Binns M, Black S 1051761600 Journal Article
International approaches to frontotemporal dementia diagnosis: From social cognition to neuropsychology Annals of Neurology Miller BL, Diehl J, Freedman M, Kertesz A, Mendez M, Rascovsky K 1041397200 Journal Article
Diagnosis of Frontotemporal Dementia Geriatric Update for Primary Care 2003 Freedman M 1041397200 Presentation
Cognition and Hallucinations in Dementia with Lewy Bodies Geriatric Update for Primary Care 2003 Freedman M 1041397200 Presentation
Clinical Assessment and Management of Behavioural Disturbances in Frontotemporal Dementia VIIIth Colloque de Psychogeriatrie Freedman M 1041397200 Presentation
Frontotemoporal Dementia Second Canadian Colloquium on Dementia Freedman M 1041397200 Presentation
The Clock Test Second Canadian Colloquium on Dementia Freedman M 1041397200 Presentation
Is cerebral microembolism in mechanical prosthetic heart valves clinically relevant? Journal of Neuroimaging Nadareishvili ZG, Beletsky V, Black SE, Fremes SE, Freedman M, Kurzman D, Leach L, Norris JW 1033444800 Journal Article
Low frequency of tau mutations and further genetic heterogeneity in FTD NEUROBIOLOGY OF AGING Kawarai T, Rogaeva E, Song YQ, Moliaka Y, Medeiros H, Liang Y, Suto C, Ling S, Fong M, Kolesnikova T, Bergeron C, Lang AE, Paterson AD, Orlacchio A, Bernardi G, Rockwood K, Allegri R, Rainero I, Pinessi L, Cappa G, Kertesz A, Bruni AC, Freedman M, Ahern GL, Tuite P, Fornazzari L, St Geroge-Hyslop P 1026446400 Abstract
Changes to the Object Recognition System in Patients with Dementia of the Alzheimer’s Type BRAIN AND COGNITION Purdy KS, McMullen PA, Freedman M 1016427600 Abstract
Temporally-graded retrograde semantic memory loss in Alzheimer's Dementia: A one-year follow-up study International Neuropsychological Society 13th Annual Meeting Moscovitch M, Westmacott R, Black SE, Freedman M 1012539600 Presentation
Alzheimer's Disease: Defining the expanding role of the family physician Canadian Family Physician's Home Care Solutions Lee PE, Freedman M 1009861200 Book Chapter
Potential interactions between herbal medicines and conventional drug therapies used by older adults attending a memory clinic Drugs & Aging Dergal JM, Gold JL, Laxer DA, Lee MSW, Binns MA, Lanctot KL, Freedman M, Rochon PA 1009861200 Journal Article
Differential memory impairment in dementia with Lewy Bodies and Alzheimer's Disease BRAIN AND COGNITION Simard M, van Reekum R, Myran D, Panisset M, Cohen T, Freedman M, Black S, Suvajac B 1009861200 Abstract
Is low-dose oral cobalamin enough to normalize cobalamin function in older people? Journal of the American Geriatrics Society Garcia A, Paris-Pombo A, Evans L, Day A, Freedman M 1009861200 Journal Article
Depression Parkinson's Disease: Diagnosis and Clinical Management Chow TW, Verhoeff NPLG, Takeshita S, St Jacques PL, Freedman M, Black S, Wilson A, Hussey D, Houle S, Meyer J 1009861200 Book Chapter
Discussion on Dementia Round Table Discussion Freedman M 1009861200 Presentation
Frontotemporal Dementia Third Annual Behavioural Neurology Clinic Day Freedman M 1009861200 Presentation
Dementia with Lewy Bodies Third Annual Behavioural Neurology Clinic Day Freedman M 1009861200 Presentation
Clock Drawing in Normal Aging and Neurological Disease Symposium Freedman M 1009861200 Presentation
Social Cognition in Frontotemporal Dementia Frontotemporal Dementia an Pick's Disease Conference Freedman M 1009861200 Presentation
Clinical Aspects of Frontotemporal Dementia 3rd Annual Commitment to Care - Southwestern Ontario Chapters of the Alzheimer Society Freedman M 1009861200 Presentation
Diagnosis and Treatment of Early Alzheimer's Disease Alzheimer Society of York Region: Demystifying Dementia Symposium Freedman M 1009861200 Presentation
Ideomotor and ideational apraxia in early Alzheimer's disease NEUROLOGY Chayer C, Xerri T, Mar W, Cohen S, Stuss DT, Freedman M 989121600 Abstract
Frontal Deficits in Alzheimer's Disease BRAIN AND COGNITION Freedman M 985064400 Abstract
Bedside Approach to Cognitive Assessment 11th Annual Rotman Research Institute Conference: Dementia - Biological and Clinical Advances Freedman M 984891600 Presentation
Frontotemporal Dementia BRAIN AND COGNITION Freedman M 984891600 Presentation
Is cerebral microembolism in prosthetic heart valves clinically relevant? STROKE Nadareishvili ZG, Beletsky V, Black S, Fremes S, Freedman M, Kurzman D, Leach L, Norris JW 982126800 Abstract
Quantifying qualitative features of block design performance among healthy older adults Archives of Clinical Neuropsychology Joy S, Fein D, Kaplan E, Freedman M 981003600 Journal Article
Relationship of psychosis to aggression, apathy and function in dementia International Journal of Geriatric Psychiatry Rapoport MJ, van Reekum R, Freedman M, Streiner D, Simard M, Clarke D, Cohen T, Conn D 981003600 Journal Article
Different patterns of autobiographical memory loss in semantic dementia and medial temporal lobe amnesia: a challenge to consolidation theory Neurocase Westmacott R, Leach L, Freedman M, Moscovitch M 978325200 Journal Article
Frontal Lobe Functions Current Neurology and Neuroscience Reports Chayer C, Freedman M 978325200 Journal Article
Assessment of Cognitive Function: A Bedside Approach Symposium on Alzheimer's Disease and Related Disorders: An Afternoon for Clinical Understanding, Management and Sharing Freedman M 978325200 Presentation
Frontotemporal Dementia Symposium on Alzheimer's Disease and Related Disorders: An Afternoon for Clinical Understanding, Management and Sharing Freedman M 978325200 Presentation
Cognitive Aspects of Dementia with Lewy Bodies Lewy Body Dementia Course. 36th Meeting of the Canadian Congress of Neurological Sciences Freedman M 978325200 Presentation
Frontotemporal Dementia First Canadian Colloquium on Dementia Freedman M 978325200 Presentation
Differential Diagnosis of Dementia First Canadian Colloquium on Dementia Freedman M 978325200 Presentation
Differential Diagnosis of Frontotemporal Dementia versus Alzheimer's Disease Practical Advances in Dementia Management Freedman M 978325200 Presentation
Diagnostic Challenges Practical Advances in Dementia Management Freedman M 978325200 Presentation
Personalized semantics: Autobiographical significance influences lexical and semantic knowledge as evidenced by healthy controls and neurological patients. Psychonomic Society Moscovitch M, Westmacott R, Black SE, Freedman M 978325200 Presentation
Frontal deficits in Alzheimer's disease Brain and Cognition Presentation Abstract Freedman M 978325200 Presentation
Normal patterns on Tc-99m-ECD brain SPECT scans in adults Journal of Nuclear Medicine Tanaka F, Vines D, Tsuchida T, Freedman M, Ichise M 967780800 Journal Article
Vitamin B12 deficiency and incontinence in older people Canadian Journal of Urology Garcia A, Smith M, Freedman M 946702800 Journal Article
Speed and memory in WAIS-R-NI Digit Symbol performance among healthy older adults Journal of the International Neuropsychological Society Joy S, Fein D, Kaplan E, Freedman M 946702800 Journal Article
Troubles de la reconnaisance dans la maladie de Parkinson Actualités sur la Maladie d'Alzheimer et les Syndromes Apparentés Ergis A-M, Winocur G, Saint-Cyr J, Van der Linden M, Melo B, Freedman M 946702800 Book Chapter
Aphasia Alberta Heritage Fund For Medical Research Visiting Lecturer Freedman M 946702800 Presentation
The Behavioural Neurology Program at Baycrest Alberta Heritage Fund For Medical Research Visiting Lecturer Freedman M 946702800 Presentation
Frontotemporal Dementia Alberta Heritage Fund For Medical Research Visiting Lecturer Freedman M 946702800 Presentation
Clinical Approach to Aphasia Behavioural Neurology Clinic Day Freedman M 946702800 Presentation
Dementia Update Issues in Geriatric Medicine, Baycrest Centre For Geriatric Care Freedman M 946702800 Presentation
Cognitive Impairment Following Stroke Workshop: 31st Heart and Stroke Clinical Update Freedman M 946702800 Presentation
Normal Tc-99m-ECD SPECT patterns in adults JOURNAL OF NUCLEAR MEDICINE Tanaka F, Vines D, Tuchida T, Freedman M, Otsubo H, Snead C, Ichise M 926481600 Abstract
Information multiple choice among healthy older adults: Characteristics, correlates, and clinical implications Clinical Neuropsychologist Joy S, Fine D, Kaplan E, Freedman M 917845200 Journal Article
Ventral frontal contribution to self-regulation: Convergence of episodic memory and inhibition Neurocase Levine B, Freedman M, Dawson D, Black S, Stuss DT 915166800 Journal Article
A neuropsychological comparison of demented and nondemented patients with Parkinson's disease Applied Neuropsychology Zakzanis KK, Freedman M 915166800 Journal Article
Learning needs of Canadian neurologists Annals of the Royal College of Physicians and Surgeons of Canada Morris B, Suchowersky O, Freedman M, Edmeads J, Becker W, Purdy A 915166800 Journal Article
The use of clock tests in schizophrenia General Hospital Psychiatry Herrmann N, Kidron D, Shulman KI, Kaplan E, Binns M, Soni J, Leach L, Freedman M 915166800 Journal Article
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria Neurology Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF 912488400 Journal Article
Age-related changes in D2 receptor binding with Iodine-123-Iodobenzofuran SPECT Journal of Nuclear Medicine Ichise M, Ballinger JR, Tanaka F, Moscovitch M, St George-Hyslop PH, Raphael D, Freedman M 904622400 Journal Article
L-deprenyl in Alzheimer's disease: Cognitive and behavioral effects Neurology Freedman M, Rewilak D, Xerri T, Cohen S, Gordon AS, Shandling M, Logan A 888728400 Journal Article
Clustering and switching on verbal fluency tests in Alzheimer's and Parkinson's disease Journal of the International Neuropsychological Society Troyer AK, Moscovitch M, Winocur G, Leach L, Freedman M 888728400 Journal Article
Clock tests in depression, Alzheimer's disease, and elderly controls International Journal of Psychiatry in Medicine Herrmann N, Kidron D, Shulman KI, Kaplan E, Binns M, Leach L, Freedman M 883630800 Journal Article
Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE Neuroscience Letters Song YQ, Rogaeva E, Premkumar S, Brindle N, Kawarai T, Orlacchio A, Yu G, Levesque G, Nishimura M, Ikeda M, Pei Y, O'Toole C, Duara R, Barker W, Sorbi S, Freedman M, Farrer L, St George-Hyslop P 883630800 Journal Article
Structural and functional meta-analytic evidence for fronto-subcortical system deficit in progressive supranuclear palsy Brain and Cognition Zakzanis KK, Leach L, Freedman M 883630800 Journal Article
Orbitofrontal function, object alternation and perseveration Cerebral Cortex Freedman M, Black S, Ebert P, Binns MA 883630800 Journal Article
Effect of age on dopamine D2 receptor binding with iodine-123-IBF SPECT JOURNAL OF NUCLEAR MEDICINE Ichise M, Ballinger JR, Moscovitch M, StGeorgeHyslop PH, Raphael D, Freedman M 865137600 Abstract
Impaired Recognition in Parkinson's Disease BRAIN AND COGNITION Ergis AM, Winocur G, Saint-Cyr J, Van der Linden M, Melo B, Freedman M 857192400 Abstract
Breakdown of cross-modal function in dementia Neuropsychiatry, Neuropsychology, and Behavioral Neurology Freedman M, Oscar-Berman M 852094800 Journal Article
Orienting of visual attention in Alzheimer's disease. Its implication in favor of the interhemispheric balance Neuropsychiatry, Neuropsychology, and Behavioral Neurology Caffarra P, Riggio L, Malvezzi L, Scaglioni A, Freedman M 852094800 Journal Article
Dementia in the Elderly Encyclopedia of Human Biology Second Edition Osimani A, Freedman M 852094800 Book Chapter
Subcortical dementia: A neurobehavioral approach Brain and Cognition Darvesh S, Freedman M 836193600 Journal Article
Usefulness of follow-up regional cerebral blood flow measurements by single-photon emission computed tomography in the differential diagnosis of dementia Journal of Neuroimaging Golan H, Kremer J, Freedman M, Ichise M 820472400 Journal Article
Motor Functioning The Cognitive Neuropsychology of Alzheimer's Disease Kidron D, Freedman M 820472400 Book Chapter
Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases Neuroscience Letters Tsuda T, Chi H, Liang Y, Rogaeva EA, Sherrington R, Levesque G, Ikeda M, Rogaev EI, Pollen D, Freedman M, Duara R, St George-Hyslop PH 788936400 Journal Article
Cognitive and Behavioural Changes in the Parkinson-Plus Syndromes Advances in Neurology Cohen S, Freedman M 788936400 Book Chapter
Comparison of patients with Alzheimer's and Parkinson's disease on different explicit and implicit tests of memory Neuropsychiatry, Neuropsychology, and Behavioral Neurology Huberman M, Moscovitch M, Freedman M 757400400 Journal Article
Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein C II genes due to linkage disequilibrium? Annals of Neurology Tsuda T, Lopez R, Rogaeva EA, Freedman M, Rogev E, Drakman D, Polland D, Haines J, Crapper-McLachlan DR, Duara R, St George-Hyslop P 757400400 Journal Article
Neuropsychological test performance in patients with dominantly inherited spinocerebellar ataxia: Relationship to ataxia severity Neurology Kish SJ, El-Awar M, Stuss D, Nobrega J, Currier R, Aita JF, Schut L, Zoghbi HY, Freedman M 757400400 Journal Article
SPECT for differential diagnosis of dementia and correlation of rCBF with cognitive impairment Canadian Journal of Neurological Sciences Osimani A, Ichise M, Dae-Gyun C, Pogue J, Freedman M 757400400 Journal Article
Frontal and parietal lobe dysfunction in depression: Delayed alternation and tactile learning deficits Neuropsychologia Freedman M 757400400 Journal Article
Assessment of regional cerebral perfusion by technetium-99m HM-PAO SPECT in chronic fatigue syndrome Nuclear Medicine Communications Ichise M, Salit IE, Abbey SE, Ghung DG, Gray B, Kirsh JC, Freedman M 694242000 Journal Article
The noisy elderly patient: Prevalence, assessment, and response to the antidepressant doxepin Journal of Geriatric Psychiatry and Neurology Friedman R, Gryfe CI, Tal DT, Freedman M 694242000 Journal Article
Selective delayed alternation deficits in dominantly inherited olivopontocerebellar atrophy Brain and Cognition Elawar M, Kish S, Oscarberman M, Robitaille Y, Schut L, Freedman M 678340800 Journal Article
The effects of age on Wisconsin Card Sorting variables JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY Leach LR, Warner CM, Hotz-Sud R, Kaplan E, Freedman M 666421200 Abstract
Assessment of cognitive impairment: The role of CT Canadian Journal of Neurological Sciences Varga M, Wortzman G, Freedman M 662706000 Journal Article
Assessment of competency: The role of neurobehavioral deficits Annals of Internal Medicine Freedman M, Stuss DT, Gordon M 662706000 Journal Article
Dementia in the Elderly Encyclopedia of Human Biology First Edition Osimani A, Freedman M 662706000 Book Chapter
Delayed Response Tasks - Parallels between experimental ablation studies and findings in patients with frontal lesions Frontal Lobe Function and Dysfunction Oscar-Berman M, McNamara P, Freedman M 662706000 Book Chapter
Alzheimer's Disease - Clinical Diagnosis and Management Clinical Review Neurology Schiffer L, Freedman M 662706000 Book Chapter
Piecing Together the Signs of Alzheimer's Disease Canadian Journal of Diagnosis Cohen S, Freedman M 662706000 Book Chapter
Functional Anatomy Dementia and Communication - Research and Clinical Implications Osimani A, Freedman M 662706000 Book Chapter
Orienting of visual attention in Alzheimer's and Parkinson's disease NEUROBIOLOGY OF AGING Freedman M, Caffarra P, Scaglioni A, Abbati C, Warner C, Pogue J, Liotti M 641534400 Abstract
Object alternation and orbitofrontal system dysfunction in Alzheimer's and Parkinson's disease Brain and Cognition Freedman M 631170000 Journal Article
Evaluating dementia: What price testing? Canadian Medical Association Journal Gordon M, Freedman M 631170000 Journal Article
Cross-modal functions in alcoholism and aging Neuropsychologia Oscar-Berman M, Pulaski JL, Hutner N, Altman Weber D, Freedman M 631170000 Journal Article
Parkinson's Disease Subcortical Dementia Freedman M 631170000 Book Chapter
Non-Alzheimer type pattern of brain cholineacetyltransferase reduction in dominantly inherited olivopontocerebellar atrophy Annals of Neurology Kish SJ, Robitaille Y, El-Awar M, Simmons J, Schut L, Chang L, Distefano L, Freedman M 599634000 Journal Article
Spatial and visual learning deficits in Alzheimer's and Parkinson's disease Brain and Cognition Freedman M, Oscar-Berman M 599634000 Journal Article
Cognitive deficits in olivopontocerebellar atrophy: Implications for the cholinergic hypothesis of Alzheimer's dementia Annals of Neurology Kish SJ, El-Awar M, Leach L, Oscar-Berman M, Schut L, Freedman M 568011600 Journal Article
Explicit and implicit memory in patients with Parkinson's and Alzheimer's Disease 9th International Symposium on Parkinson's Disease Moscovitch M, Huberman M, Freedman M 568011600 Presentation
Response of Tardive and L-Dopa-Induced Dyskinesias to Anti-depressants Canadian Journal of Neurological Sciences El-Awar M, Freedman M, Seeman P, Goldenberg L, Little J, Solomon P 536475600 Journal Article
Tactile discrimination learning deficits in Alzheimer's and Parkinson's diseases Archives of Neurology Freedman M, Oscar-Berman M 536475600 Journal Article
Screening for Dementia Medicine North America Freedman M 504939600 Journal Article
Mnemonic precedence in amnesic patients: an analogue of the AB error in infants? Child Development Schacter DL, Moscovitch M, Tulving E, Freedman M 504939600 Journal Article
Selective delayed response deficits in Parkinson's and Alzheimer's disease Archives of Neurology Freedman M, Oscar-Berman M 504939600 Journal Article
Comparative neuropsychology of cortical and subcortical dementia Canadian Journal of Neurological Sciences Freedman M, Oscar-Berman M 504939600 Journal Article
Stuttering: Disappearance and reappearance with acquired brain lesions Neurology Helm-Estabrooks N, Yoe R, Geschwind N, Freedman M, Weinstein C 504939600 Journal Article
Semantic encoding deficits in frontal lobe disease and amnesia Brain and Cognition Freedman M, Cermak LS 504939600 Journal Article
Bilateral frontal lobe disease and selective delayed-response deficits in humans Behavioral Neuroscience Freedman M, Oscar-Berman M 504939600 Journal Article
Catecholamine metabolites and cyclic nucleotides in cerebrospinal fluid in dementia of Alzheimer type Journal of Gerontology Volicer L, Direnfeld LK, Langlais PJ, Freedman M, Bird ED, Albert ML 473403600 Journal Article
Serotonin and 5-hydroxyindoleacetic acid in CSF: Difference in Parkinson's disease and dementia of the Alzheimer's type Archives of Neurology Volicer L, Direnfeld LK, Freedman M, Albert ML, Langlais PJ, Bird ED 473403600 Journal Article
Cholinesterase activity in plasma, erythrocytes, and cerebrospinal fluid of patients with dementia of the Alzheimer type Biological Psychiatry Marquis JK, Volicer L, Mark KA, Direnfeld LK, Freedman M 473403600 Journal Article
Subcortical dementia Handbook of Clinical Neurology Freedman M, Albert ML 473403600 Book Chapter
Cortical and subcortical dementia Annals of Neurology Freedman M 441781200 Journal Article
Amnesia after anterior communicating artery aneurysm rupture Neurology Alexander MP, Freedman M 441781200 Journal Article
Anatomic basis of transcortical motor aphasia Neurology Freedman M, Alexander MP, Naeser M 441781200 Journal Article
Retrograde amnesia in Parkinson's disease Canadian Journal of Neurological Sciences Freedman M, Rivoira P, Butters N, Sax D, Feldman RG 441781200 Journal Article
Computerized Axial Tomography in Aging Clinical Neurology of Aging Freedman M, Knoefel JE, Naeser MA, Levine HL 441781200 Book Chapter
Functional retrograde amnesia - A quantitative case study Neuropsychologia Schacter DL, Wang PL, Tulving E, Freedman M 378709200 Journal Article
Widespread cerebral haemodynamics disturbances occur early in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis Murphy MJ, Grace GM, Tartaglia MC, Orange JB, Chen X, Rowe A, Findlater K, Kozak RI, Freedman M, Lee T-Y, Strong MJ -28800 Journal Article
Standardized norms for the Freedman version of the Clock Drawing Test. J of Clinical and Experimental Neuropsychology Caffarra P, Gardini S, Zonato F, Concari L, Diecl F, Copelli S, Freedman M, Stracciari A, Venneri A -28800 Journal Article
Progressive difficulty naming and object identification Case studies in Dementia: Common and Uncommon causes Blanco M, and Freedman M -28800 Book Chapter
Psi and the Brain. Mysterious Minds: The Neurobiology of Psychics, Mediums and Other Extraordinary People Freedman M -28800 Book Chapter
Clinical Phenemenology and treatment of frontotemporal dementia Dementia and Motor Neuron Disease Freedman M -28800 Book Chapter

Education

  • 1971: BSc, University of Toronto
  • 1975: MD (Medicine) , University of Ottawa
  • 1983: FRCPC, Neurology,

Academic Appointments

  • 2000–Present: Head, Division of Neurology, Baycrest Health Sciences (changed from "Head, Division of Neurology, and Scientist", end data 2025 - 2017 03)
  • 1997–Present: Coordinator, Behavioural Neurology Section, Division of Neurology, University of Toronto
  • 1990–2000: Associate Professor, Faculty of Medicine , University of Toronto
  • 1985–1990: Assistant Professor, Faculty of Medicine, University of Toronto
  • 1989–Present: Head, Division of Neurology and Director, Behavioural Neurology Program, Baycrest Hospital
  • 1988–Present: Graduate Faculty, Institute of Medical Science, University of Toronto
  • 1986–Present: Professor, Faculty of Medicine (Neurology), University of Toronto (extemded tp 2025 - 2017 03)
  • 1984–Present: Associate Staff Scientist, Mount Sinai Research Institute, Mount Sinai Hospital
  • 1983–2010: Staff Neurologist, Mount Sinai Hospital and Baycrest Centre for Geriatric Care, Toronto, Canada
  • 1998–Present: Staff Neurologist, University Health Network, Toronto, Canada
  • 1983–1985: Lecturer, Faculty of Medicine, University of Toronto
  • 2010–Present: Director, Behavioural Neurology Section, Division of Neurology, University of Toronto
  • 2012–2015: Executive Medical Director, Centre for Memory and Neurotherapeutics, Baycrest Health Sciences
  • 1990–Present: Scientist, Rotman Research Institute, Baycrest Health Sciences
  • 2015–Present: Medical Director, Cognition & Behaviour, Baycrest Health Sciences

Research Projects

External

  • 2008–2010: The Effect of Lifelong Bilingualism on the Onset and Progression of Alzheimer Disease
    Collaborators: E Bialystok (PI), F Craik

    Sponsors: Alzheimer Society of Canada, $94,826

  • 2008–2011: Assessing Driving Performance in Persons with Mild Cognitive Impairment and Mild Dementia.
    Collaborators: G Naglie (PI), S Black, I Gelinas, N Herrman, N Korner-Bitensky, M Man-Son-Hing, S Marshall, M Rapoport, D Tang-Wai, G Tomlinson, H Tuokko

    Sponsors: CIHR, $191,860

  • 2007–2012: The Language Impairment in Progressive Aphasia: A Longitudinal Neuropsychological and Imaging Study
    Collaborators: E Rochon (PI), S Black (PI), B Levine, C Leonard, T Chow, D Tang-Wai, N Graham

    Sponsors: CIHR, $511,835

  • 2007–2009: Theory of Mind in Alzheimer's Disease and Frontotemporal Dementia
    Collaborators: D Stuss, S Black, M Binns

    Sponsors: OMHF, $148,784

  • 2006–2008: Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia
    Collaborators: N Herrman (PI), K Lanctot, S Black, T Chow

    Sponsors: Alzheimer Society of Canada, $79,858

  • 2006–2009: B-Amyloid PET Imaging in Alzheimer's Disease
    Collaborators: NP Verheoff (PI), R Van Reekum, S Houle, A Wilson

    Sponsors: Alzheimer Society of Canada, $99,913

  • 2006–2008: Cognitive Behaviour Therapy for Family Caregivers of Older Adults with Dementia
    Collaborators: C Mackenzie (PI), D Conn, N Khatri

    Sponsors: Alzheimer Society of Canada, $48,288

  • 2006–2008: Canadian Alzheimer's Disease Quality of Life Study
    Collaborators: G Naglie (PI), G Tomlinson, D Hogan, M Krahn, J Irvine, C Patterson, M Borrie, D Streiner, S Black, C MacKnight, H Bergman, L Beattie, Y Bacher, A Byszewski, P Ritvo

    Sponsors: Alzheimer Society of Canada, $211,956

  • 2006–2007: Pharmacogenetics of Rivastigmine Response in Lewby Body Disease: A Pilot Study Employing Brain SPECT
    Collaborators: S Black (PI), M Masellis

    Sponsors: CIHR, $ 50,000

  • 2005–2006: Longitudinal Canadian Alzheimer's Disease Quality of Life Study
    Collaborators: G Naglie (PI), Y Bacher, L Beattie, H Bergman, S Black, M Borrie, A Byszewski, D Hogan, J Ingram, J Irvine, M Krahn, C MacKnight, C Patterson, P Ritvo, D Streiner, G Tomlinson

    Sponsors: CIHR, $ 50,000

  • 2004–2006: Canadian Alzheimer's Disease Quality of Life Study
    Collaborators: G Naglie (PI), Y Bacher, L Beattie, H Bergman, S Black, M Borrie, A Byszewski, D Hogan, J Ingram, J Irvine, M Krahn, C MacKnight, C Patterson, P Ritvo, D Streiner, G Tomlinson

    Sponsors: Alzheimer Society of Canada, $113,752

  • 2003–2008: Rotman Research Institute Brain and Aging Group
    Collaborators: D Stuss (PI), C Alain, S Black, T Chow, F Craik, C Grady, S Graham, L Hasher, B Levine, N Lobaugh, H Mayberg, A McIntosh, M Moscovitch, K O'Craven, C Pantev, T Picton, J Ryan, T Stefurak, E Tulving, G Winocur

    Sponsors: CIHR, $2,074,570

  • 2002–2006: Canadian Alzheimer's Disease Quality of Life Study
    Collaborators: G Naglie (PI), M Krahn, M Irvine, P Ritvo, M Silberford, S Black, D Streiner, G Tomlinson, D Hogan, H Bergman, C MacKnight, C Patterson, M Borrie, L Beattie

    Sponsors: CIHR, $565,419

  • 2002–2005: Social Cognition in Frontotemporal Dementia and Alzheimer's Disease
    Collaborators: D Stuss, S Black

    Sponsors: CIHR, $265,788

  • 2002–2004: Interactions Between Herbal Medicines and Conventional Drug Therapy
    Collaborators: P Rochon (PI), S Black, J Gurwitz, N Herrman, D Streiner

    Sponsors: Alzheimer Society of Canada, $119,474

  • 2001–2003: Risk Factors in Dementia
    Collaborators: M Percy (PI), D Andrews

    Sponsors: Alzheimer Society of Canada, $77,100

  • 1999–2000: Heterogeneity in Frontotemporal Dementia: Clinical, Anatomical, and Genetic Mechanisms
    Collaborators: M Ichise, M Moscovitch, D Raphael, P St. George-Hyslop, M Binns

    Sponsors: Medical Research Council of Canada, $12,773

  • 1998–2002: Rehabilitation of Executive Dysfunction Following Focal Lesions, "Traumatic Brain Injury and Aging"
    Collaborators: D Stuss (PI), M Alexander, S Black, M Cusimano, F Craik, D Dawson, C Grady, L Jacoby, B Levine, B Koel, R McIntosh, M Moscovitch, G Proulx, I Robertson, M Schwartz, G Winocur

    Sponsors: James S McDonnell Foundation, $840,000

  • 2006–2008: An Open-Label Pilot Study of the Effects of Acute Memantine Administration on FDG-PET in Frontotemporal Dementia
    Collaborators: T Chow (PI), M Binns, H Dombrower, B Pollock, G Smith, P Verhoeff

    Sponsors: Lundbeck Canada Inc, $161,992

    Contract Research
  • 2002–2004: Olanzipine versus Trazadone for Treatment of Agitation in Dementia
    Collaborators: P Lee, D Conn, B Richards, L Duanal

    Sponsors: Eli Lilly Canada Inc, $66,112

    Contract Research
  • 1999–2000: Cognitive and Regional Brain Perfusion of Aricept in Probable Alzheimer's Disease
    Collaborators: S Black (Co-PI), C Caldwell, L Ehrlich, M Ichise

    Sponsors: Pfizer Canada Inc, $72,826

    Contract Research
  • 2009–2010: Slowing Language Decline in Progressive Aphasia through Language Rehabilitation: Treatment and Neuroimaging Study
    Collaborators: R Jokel (PI), D Tang-Wai, E Rochon, L DeNil, N Anderson, S Black, S Graham, T Chow

    Sponsors: CIHR, $81,530

  • 2011–2013: Parkinson's-related dementia: A pharmacogenomic study of cholinesterase inhibitors investigating cognitive benefit, motor worsening, and brain SPECT
    Collaborators: M Masellis (PI), B Macintosh, D Tang-Wai, J Kennedy, J Lee, Kleiner-Fishman, N Herrmann, R Chen, S Black

    Sponsors: Parkinson Society Canada, $90,000

  • 2013–2016: Validation of ocular measures as potential biomarkers for early detection of brain amyloid and neurodegeneration
    Collaborators: S Black (PI), A Kiss, A Lang, A Voineskos, B Greenberg, B Pollock, C Tartaglia, C Hudson, C Fischer, C Caldwell, D Tang-Wai, E Margolin, E Mandelcorn, E Rogaeva, J Valliant, M Masellis, R Schwartz, S Strother, S Houle, T Chow, V Yang

    Sponsors: Weston Foundation - Brain Canada, $1,498,490

  • 2012–2018: Improving performance in drivers with mild cognitive impairment: An RCT of cognitive training
    Collaborators: G Naglie (PI), B Levine, C Fischer, D Dawson, D Tang-Wai, M Bedard, M Binns, N Herrmann, N Korner-Bitensky, S Black, T Schweizer

    Sponsors: CIHR, $562,766

  • 2015–2019: ALEVIATE - A randomized controlled trial of levetiracetam to reduce hippocampal volume loss in subjects with amnestic mild cognitive impairment
    Collaborators: N Herrmann (PI), A Kiss, B Greenberg, B Pollock, C Tartaglia, C Fischer, D Tang-Wai, D Weaver, K Lanctot, Mario Masellis, M McAndrews, R Olsen, S Black, S Kumar, S Strother

    Sponsors: W. Garfield Weston Foundation, $1,499,998

Research Training

1975-1976 Internship (rotating), Toronto General Hospital, University of Toronto, Ontario

1976-1977 Resident in Medicine, Toronto General Hospital, University of Toronto

1977-1978 Resident in Neurology, Sunnybrook Medical Centre, University of Toronto

1978 (July - Dec) Resident in Neurology, Mount Sinai Hospital, University of Toronto

1979 (Jan - June) Senior Resident in Neurology, Toronto General Hospital, University of Toronto

1979 (July - Dec) Resident in Neurology (Neuropathology rotation), Banting Institute, University of Toronto

1980 (Jan - June) Resident in Neurology (Electroencephalography rotation),Toronto Western Hospital, University of Toronto

1980 (July - Dec) Physician, Division of Neurology, Mount Sinai Hospital, Toronto, Ontario

Jan 1981 - June 1983 Behavioural Neurology Fellow, Neurobehavioural/Aphasia Unit, Boston Veterans Administration Medical Center, Boston, Massachusetts