Assistant Professor of Psychiatry Department of Geriatric Psychiatry, University of Toronto
Clinical Scientist Rotman Research Institute, Baycrest Centre for Geriatric Care
My research focuses on the on the use of behavioural paradigms and brain imaging to study cognitive and emotional processing and the neurobiology of mood and anxiety disorders. Behavioural and neuroimaging studies have demonstrated abnormalities of information processing and structures including the amygdala and anatomically-related limbic and paralimbic regions as pathogenetic mechanisms for major depressive disorder in mid-life, but little is known regarding emotional processing and its neural correlates in elderly depressed individuals. We are currently conducting fMRI studies designed to evaluate emotional processing and brain activity in geriatric depression. We will determine whether abnormalities in the unmedicated, depressed state are predictive of treatment response and whether there are associations with cognitive deficits and other clinical variables. We hypothesize that patterns of emotional processing and activation of specific brain regions including the amygdala, anterior cingulate, orbital cortex, and ventral striatum, will differentiate elderly depressed subjects from age-matched healthy control subjects. The identification of specific neuroanatomical targets using fMRI may inform the development of new and more effective strategies for treatment of depression in late life.
Title | Source (Journal/Book/Conference) | Authors/Presenters | Published On | Type |
---|---|---|---|---|
Negative emotional verbal memory biases in mild cognitive impairment and late-onset depression | American Journal of Geriatric Psychiatry | Mah L, Anderson ND, Verhoeff NPLG, Pollock BG | 1494388800 | Journal Article |
Dynamic working memory performance in individuals with single-domain amnestic mild cognitive impairment | Journal of Clinical and Experimental Neuropsychology | Guild EB, Vasquez BP, Maione AM, Mah L, Ween J, Anderson ND | 1409371200 | Journal Article |
Gabapentin withdrawal: Case report in a geriatric patient and review of the literature | J Am Geriatr Soc. | Mah L, Hart, M | 1377576000 | Journal Article |
Attitudes of Terminally Ill Older Adults towards Complementary and Alternative Medicine Therapies | Journal of Palliative Care | Grief C, Grossman D, Rootenberg M, Mah L | 1374897600 | Journal Article |
Association between Patient Dignity and Anxiety in Geriatric Palliative Care | Palliative Medicine | Mah L, Grossman D, Grief C, Rootenberg M | 1369627200 | Journal Article |
Psychosocial Dimensions of Geriatric Palliative Care | American Association of Geriatric Psychiatry | Mah L, Grief C, Grossman D, Rootenberg M | 1364702400 | Abstract |
Hydrocortisone infusion exerts dose- and sex-dependent effects on attention to emotional stimuli. | Brain and cognition | Breitberg A, Drevets WC, Wood SE, Mah L, Schulkin J, Sahakian BJ, Erickson K | 1357016400 | Journal Article |
Emotional processing differentiates amnestic mild cognitive impairment and late-life depression | Human Brain Mapping | Mah L, Grady C, Anderson ND, Pollock B | 1339128000 | Abstract |
Assessment of patient dignity in geriatric palliative care. | Journal of the American Geriatrics Society | Mah L, Grief C, Grossman D, Rootenberg M | 1325394000 | Journal Article |
Neural correlates of emotion regulation in late-life depression | Society for Neuroscience | Mah L, Ye B, Leung R, Freel S, Pollock BG | 1320728400 | Abstract |
Neural circuitry of emotional processing in late-life depression | Human Brain Mapping | Mah L, Williams LJ, Leung R, Freel S, Pollock B | 1302235200 | Abstract |
Neural substrates of emotional processing in late-life depression. | Biological Psychiatry | Mah L, Williams LJ, Leung R, Freel S, Pollock B | 1302235200 | Abstract |
Neural mechanisms of antidepressant efficacy of the dopamine receptor agonist pramipexole in treatment of bipolar depression. | International Journal of Neuropsychopharmacology | Mah L, Zarate CA, Nugent AC, Singh JB, Manji HK, Drevets WC | 1293858000 | Journal Article |
Effect of stimulus exposure duration on attentional bias for fearful faces | FRONTIERS OF NEUROSCIENCE | Leung R, Drevets WC, Furey ML, Mah L | 1277784000 | Abstract |
Emotional processing deficit in late-life depression | American Journal of Geriatric Psychiatry | Mah LWY, Pollock BG | 1272600000 | Journal Article |
Emotion Regulation in Healthy Aging | Journal of Neuropsychiatry and Clinical Neurosciences | Mah L, Pollock BG | 1270699200 | Abstract |
Use of the D2/D3 receptor agonist pramipexole in treatment of rapid-cycling bipolar disorder in an elderly patient | American Journal of Geriatric Psychiatry | Mah LWY, Conn D | 1267419600 | Journal Article |
Emotional processing deficits in late-life depression | AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | Mah L, McGarry L, Pollock BG | 1236229200 | Abstract |
Dysfunctional attitudes mediate response to cognitive behavioural therapy for depression | Harvey Stancer Research Day | Mah L, McGarry L, Rossi S, Pollock BG | 1213848000 | Abstract |
Age-related differences in attentional biases for emotional stimuli | Harvey Stancer Research Day | McGarry L, Rossi S, Mah L, Pollock BG | 1213848000 | Abstract |
Age-related differences in the perception of facial emotions | Harvey Stancer Research Day | Rossi S, McGarry L, Mah L, Pollock BG | 1213848000 | Abstract |
Regional cerebral glucose metabolic abnormalities in bipolar II depression | Biological Psychiatry | Mah LWY, Zarate CA, Singh J, Duan Y-F, Luckenbaugh DA, Manji H, Drevets WC | 1173931200 | Journal Article |
Neural correlates of emotional processing biases in major depressive disorder | AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | Mah L, Wood SE, Furey ML, Fromm SJ, Pine DS, Drevets WC | 1172725200 | Abstract |
Neural correlates of automatic beliefs about gender and race | Human Brain Mapping | Knutson KM, Mah LWY, Manly CF, Grafman J | 1167627600 | Journal Article |
Sex differences in the effect of hydrocortisone on functional interactions between amygdala and orbitomedial prefrontal cortex responses to emotional stimuli | SOCIETY FOR NEUROSCIENCE ABSTRACTS | Erickson K, Harrell PT, Wood SE, Nugent AC, Schulkin J, Mah L, Furey ML, Drevets WC | 1160798400 | Abstract |
Regional cerebral glucose metabolism in discriminating bipolar depressives from nonpsychiatric controls | NEUROIMAGE | Mah L, Zarate CA, Fromm SJ, Luckenbaugh DA, Duan Y-F, Manji H, Drevets WC | 1150171200 | Abstract |
Regional cerebral glucose metabolic abnormalities in unmedicated-remitted subjects with major depressive disorder | NEUROIMAGE | Mah L, Nugent AC, Neumeister A, Charney DS, Drevets WC | 1150171200 | Abstract |
VBM detection of Volumetric Abnormalities in Bipolar Disorder | ISMRM Fourteenth Scientific Meeting & Exhibition | Nugent AC, Milham M, Bain EE, Cannon D, Mah L, Zarate C, Pine D, Drevets WC | 1146888000 | Abstract |
Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry | Neuroimage | Nugent AC, Milham MP, Bain EE, Mah L, Cannon DM, Marrett S, Zarate CA, Pine DS, Price JL, Drevets WC | 1143867600 | Journal Article |
Altered amygdala response to emotional faces in major depression | SOCIETY FOR NEUROSCIENCE ABSTRACTS | Mah L, Wood SE, Furey ML, Fromm SJ, Pine DS, Drevets WC | 1136091600 | Abstract |
Influence of low and high dose hydrocortisone infusion on hemodynamic response in amygdala while viewing emotional faces | NEUROPSYCHOPHARMACOLOGY | Erickson K, Furey ML, Schulkin J, Wood SE, Mah L, Nugent AC, Drevets WC | 1134277200 | Abstract |
Baseline cerebral metabolism, alterations in metabolism, and response to pramipexole or placebo treatment in bipolar II depression | SOCIETY FOR NEUROSCIENCE ABSTRACTS | Mah L, Zarate CA, Wood SE, Duan Y-F, Nugent AC, Cannon DM, Manji H, Drevets WC | 1131858000 | Abstract |
Differential effects of hydrocortisone on amygdala habituation to emotional facial expressions: An fMRI study | SOCIETY FOR NEUROSCIENCE ABSTRACTS | Erickson K, Wood SE, Furey ML, Nugent AC, Mah L, Schulkin J, Drevets WC | 1131858000 | Abstract |
Cerebral metabolic changes in bipolar depressed patients treated with the D2/D3 receptor agonist pramipexole | BIPOLAR DISORDERS | Zarate CA, Mah L, Duan Y-F, Nugent AC, Cannon D, Quiroz JA, Manji HK, Drevets WC | 1118894400 | Abstract |
Effect of pramipexole treatment on glucose metabolism in bipolar II depression | NEUROIMAGE | Mah L, Wood SE, Duan Y-F, Nugent AC, Cannon DM, Solorio G, Zarate CA, Manji H, Drevets WC | 1118548800 | Abstract |
Reproducibility of the hemodynamic response of the amygdala to emotional stimuli | NEUROIMAGE | Mah L, Wood SE, Fromm S, Drevets WC, Furey ML | 1118548800 | Abstract |
Influence of hydrocortisone infusion on habituation of hemodynamic response in amygdala and anterior cingulate while viewing single and multiple presentations of emotionally expressed faces | NEUROIMAGE | Erickson K, Schulkin J, Furey M, Mah L, Wood SE, Nugent AC, Chrousos G, Drevets WC | 1118548800 | Abstract |
Cortical abnormalities in treated and untreated bipolar disorder as investigated with voxel based morphometry | BIPOLAR DISORDERS | Nugent AC, Milham M, Bain EE, Mah L, Cannon D, Marrett S, Zarate C, Pine D, Drevets WC | 1117598400 | Abstract |
Cerebral metabolic changes in bipolar depressed patients treated with the D-2/D-3 receptor agonist pramipexole | BIPOLAR DISORDERS | Zarate CA, Duan YF, Mah L, Nugent AC, Quiroz JA, Singh J, Manji HK, Drevets WC | 1117598400 | Abstract |
Deficits in social knowledge following damage to ventromedial prefrontal cortex | Journal of Neuropsychiatry & Clinical Neurosciences | Mah LWY, Arnold MC, Grafman J | 1107234000 | Journal Article |
Cortical abnormalities in treated and untreated bipolar disorder as investigated with voxel based morphometry | BIPOLAR DISORDERS | Nugent AC, Milham M, Bain EE, Mah L, Cannon D, Marrett S, Zarate C, Pine D, Drevets WC | 1104555600 | Abstract |
Effect of task instructions on amygdalar response to fearful facial expressions | SOCIETY FOR NEUROSCIENCE ABSTRACTS | Mah L, Drevets WC, Wood SE, Monk CS, Nelson EE, Pine DS, Furey ML | 1098763200 | Abstract |
Effects of hydrocortisone infusion on affectively valenced autobiographical memory | Society for Neuroscience's Annual Meetings | Erickson K, Mah L, Wood SE, Chrousos GP, Schulkin J, Charney DS, Drevets WC | 1098763200 | Abstract |
Impairment of social perception associated with lesions of the prefrontal cortex | American Journal of Psychiatry | Mah L, Arnold MC, Grafman J | 1088654400 | Journal Article |
Effect of stimulus duration on the BOLD signal in the amygdala | NEUROIMAGE | Mah L, Drevets WC, Wood SE, Monk CS, Nelson EE, Pine DS, Furey ML | 1087099200 | Abstract |
Amygdalar Modulation of Cingulate Activity During Presentation of Fearful Faces | NEUROIMAGE | Wood SE, Mah L, Nelson EE, Pine DS, Monk CS, Nugent AC, Drevets WC, Furey ML | 1087099200 | Abstract |
Neuromorphometric measurements of the amygdala in medicated and unmedicated bipolar disorder | NEUROIMAGE | Nugent AC, Sills R, Bain EE, Cannon DM, Mah L, Zarate C, Drevets WC | 1087099200 | Abstract |
Voxel-based morphometry in bipolar disorder | NEUROIMAGE | Nugent AC, Millam MP, Bain EE, Cannon DM, Mah L, Pine DS, Charney DS, Drevets WC | 1087099200 | Abstract |
High resolution MRI neuromorphometric assessment of the hippocampal subiculum in mood disorders | ISMRM Twelfth Scientific Meeting & Exhibition | Nugent AC, Wood SE, Bain EE, Mah L, Cannon DM, Neumeister A, Zarate C, Marrett S, Koretsky A, Talagala L, Price J, Charney DS, Drevets WC | 1084593600 | Abstract |
Glucose metabolism in the amygdala in bipolar II depression | BIOLOGICAL PSYCHIATRY | Mah L, Duan YF, Zarate CA, Singh J, Payne JL, Nugent AC, Charney DS, Drevets WC | 1083211200 | Abstract |
Glucose Metabolism in the Amygdala in Bipolar II Depression | BIOLOGICAL PSYCHIATRY | Mah L, Duan Y-F, Zarate CA, Singh J, Payne JL, Nugent AC, Charney DS, Drevets WC | 1083211200 | Abstract |
Effect of stimulus duration on selective attention to fearful faces | JOURNAL OF COGNITIVE NEUROSCIENCE | Mah L, Wood S, Nelson K, Monk CS, Pine DS, Drevets WC, Furey ML | 1082260800 | Abstract |
Neural correlates of changes in the automaticity of gender attitudes | JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | Mah L, Manly CF, Grafman J | 1077426000 | Abstract |
Impairment of Social Perception Associated with Lesions of the prefrontal cortex | American Journal of Psychiatry | Mah LWY, Arnold MC, Grafman J | 1072933200 | Journal Article |
Neural correlates of automatic beliefs about gender and race | JOURNAL OF COGNITIVE NEUROSCIENCE | Mah L, Manly CF, Grafman J | 1052452800 | Abstract |
Impairment in social cognition following lesions of ventromedial and dorsolateral prefrontal cortex | JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | Mah L, Arnold MC, Grafman J | 1044162000 | Abstract |
Social cognition deficits in patients with frontal lobe damage | JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | Mah L, Arnold MC, Grafman J | 1015736400 | Abstract |
Do frontal behaviours change following surgery for temporal lobe epilepsy? | JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | Mah L, Benjamin S, Swearer J, Phillips C, Weaver J | 983077200 | Abstract |
A comparison of hemispatial neglect from posterior parietal and periarcuate lesions in the monkey | Psychobiology | Crowne DP, Mah LWY | 883630800 | Journal Article |
Sponsors: Alzheimer Society of Canada
Sponsors: CIHR
Sponsors: OMHF
Sponsors: Scottish Rite Charitable Foundation of Canada
Sponsors: Ministry of Health and Long-Term Care- AFP Innovation Fund
Sponsors: University of Toronto Faculty of Medicine
Sponsors: Baycrest Department of Psychiatry Academic Development Fund,
Sponsors: Baycrest Department of Psychiatry Academic Development Fund
Sponsors: Baycrest Department of Psychiatry Academic Development Fund
Research Fellow (Supervisor: Wayne Drevets, M.D.), 2002-2006
Section on Neuroimaging in Mood and Anxiety Disorders, NIMH
Clinical Fellow (Supervisor: Jordan Grafman, Ph.D.), 2000-2002
Cognitive Neuroscience Section, NINDS, NIH
Clinical Neuropsychiatry Fellow (Supervisor: Sheldon Benjamin, M.D.), 1999-2000
University of Massachusetts Medical School, Worcester, MA
Resident, Psychiatry, 1994-1999
McGill University, Montreal, Quebec
College of Physicians and Surgeons of Ontario, 2000- present
American Board of Psychiatry and Neurology, Psychiatry, 2000
Royal College of Physicians and Surgeons of Canada, Psychiatry, 1999
College des Medicins du Quebec, Psychiatry, 1999
Licentiate of the Medical Council of Canada, 1996
Faculty of Medicine, McGill University, Montreal, Quebec
Introduction to the Patient, Seminar Leader, 1999, 4 hours
Department of Psychiatry, Faculty of Medicine, McGill University, Montreal
Introduction to Clinical Medicine – Psychiatry, Lecturer, 1997, 8 hours
Department of Psychology, University of Waterloo, Waterloo, Ontario
Research Methods and Statistics, Teaching Assistant, 1989, 20 hours
Baycrest, University of Toronto
Coordinator and Seminar Leader, Evidence-Based Medicine Rounds, Department of Psychiatry, Sept 2012- present, 10 hours/year
Baycrest, University of Toronto
Psychiatric Formulation – Psychiatry Residency Teaching, 2010- present, 3 hours/year
Baycrest, University of Toronto
Statistics/Critiquing Journal Articles – Psychiatry Residency Teaching, 2011- present, 2 hours/year
Baycrest, University of Toronto
How to Critique Journal Articles in Psychiatry – Evidence-Based Medicine Seminar, 2009-2010, 2-3 hours/year, overall rating 4.5/5
Baycrest, University of Toronto
PDQ Statistics – Evidence-Based Medicine Seminar, 2009-2010, 2-3 hours/year, overall rating 4.5/5
Baycrest, University of Toronto
Personality Disorders in the Elderly – Psychiatry Residency Teaching, 2007, 1 hour
Allan Memorial Institute, McGill University
Psychiatry Clinical Clerkship, Teaching Fellow, 1997-1998, 250 hours
Psychiatric Interviewing Course
Problem-based Learning – Psychiatric Diagnosis and Management
Mock Oral Examiner
Allan Memorial Institute, McGill University
Psychotropic Medications in Pregnancy – Psychiatric Residency Teaching, 1997, 1 hour
Montreal General Hospital, McGill University
Anxiety Disorders – Clinical Clerk Teaching, 1997, 1 hour
St. Mary’s Hospital, McGill University
Delusional Disorders in the Elderly – Family Medicine Resident Teachin, 1997, 2 hours
Allan Memorial Institute, McGill University
Neuroleptics – Clinical Clerk Teaching, 1996, 6 hours
Organic Brain Syndromes – Clinical Clerk Teaching, 1996, 6 hours
Substance Intoxication and Withdrawal – Psychiatry Resident Teaching, 1996, 1 hour
SSRIs and the Cytochrome P450 System – Psychiatry Resident Teaching, 1996, 1 hour
Montreal General Hospital, McGill University
Anxiety Disorders – Clinical Clerk Teaching, 1995, 6 hours
Baycrest, University of Toronto, Toronto, Ontario, 2010
Mock oral examiner for psychiatry residents
McGill Teaching Hospitals, 1994-1999
Supervision of clinical clerks in emergency, inpatient, and consultation-liaison psychiatry
Mock oral examiner for clinical clerks
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