Research | Baycrest

Meltzer, Jed Dr.

Jed Meltzer

Dr. Jed Meltzer, Ph.D.

Research Focus

My research deals with the neural mechanisms responsible for understanding and producing language, with an emphasis on multiple partially redundant pathways. The study of multiple pathways for information processing is essential to future developments in stroke rehabilitation, as functional and structural assessments can be made of an individual's capacity to exploit spared pathways to recover cognitive and linguistic abilities. Behavioural intervention strategies could be tailored to an individual's post-stroke neuroanatomical status for maximal effect. My work has explored the potential of magnetoencephalography as a mapping tool in neurolinguistics, providing the spatial and temporal resolution necessary to measure the involvement of specific neural pathways on a time scale relevant to everyday language use. More recent work aims at a closer integration between the fields of cognitive neuroscience and computational linguistics. Assessment of language function in neurological patients has traditionally depended on behavioural tests administered by a trained professional under somewhat artificial conditions. Although these tests provide invaluable information, they do not capture more subtle aspects of variability in language use, especially those associated with milder forms of impairment as present in dementia and traumatic brain injury patients. Recently numerous tools have become available for automated analysis of naturalistic language samples that are easily obtained from patients. Studies have revealed quantifiable aspects of language use associated with normal aging and neurological impairment, but the relationship of these factors to neuroanatomical pathways remains to be explored. Current studies in my lab will develop the potential of computational linguistics tools to contribute towards improved diagnosis and treatment of cognitive impairment in stroke and progressive disorders.

Publications

Title Source (Journal/Book/Conference) Authors/Presenters Published On Type
An EEG-MEG dissociation between online syntactic comprehension and posthoc reanalysis Frontiers in Human Neuroscience Meltzer JA, Braun AR 1296795600 Journal Article
Infraslow EEG oscillations organize large-scale cortical-subcortical interactions during sleep: A combined EEG/fMRI study Brain Research Picchioni D, Horovitz SG, Fukunaga M, Carr WS, Meltzer JA, Balkin TJ, Duyn,JH, Braun AR 1296795600 Journal Article
Neural aspects of sentence comprehension: syntactic complexity, reversibility, and reanalysis. Cerebral Cortex Meltzer JA, McArdle JJ, Schafer RJ, Braun AR 1280635200 Journal Article
Strategies for longitudinal neuroimaging studies of overt language production. NeuroImage Meltzer JA, Postman-Caucheteux WA, McArdle JJ, Braun AR 1250308800 Journal Article
Neural correlates of evaluative compared with passive tasting. European Journal of Neuroscience Bender G, Veldhuizen MG, Meltzer JA, Gitelman DR, Small DM 1247630400 Journal Article
Transverse patterning dissociates human EEG theta power and hippocampal BOLD activation. Psychophysiology Meltzer JA, Fonzo GA, Constable RT 1230786000 Journal Article
Effects of working memory load on oscillatory power in human intracranial EEG. Cerebral Cortex Meltzer JA, Zaveri HP, Goncharova II, Distasio MM, Papademetris X, Spencer SS, Spencer DD, Constable RT 1217563200 Journal Article
Biphasic hemodynamic responses influence deactivation and may mask activation in block-design fMRI paradigms. Human Brain Mapping Meltzer JA, Negishi M, Constable RT 1207022400 Journal Article
Individual differences in EEG theta and alpha dynamics during working memory correlate with fMRI responses across subjects Clinical Neurophysiology Meltzer JA, Negishi M, Mayes LC, Constable RT 1193889600 Journal Article
A functional magnetic resonance imaging study of the long-term influences of early indomethacin exposure on language processing in the brains of prematurely born children. Pediatrics Ment LR, Peterson BS, Meltzer JA, Vohr B, Allan W, Katz KH, Lacadie C, Schneider KC, Duncan CC, Makuch RW, Constable RT 1157083200 Journal Article
Activation of human hippocampal formation reflects success in both encoding and cued recall of paired associates NeuroImage Meltzer JA, Constable RT 1105765200 Journal Article
Temperature dependence of non-linear capacitance in human embryonic kidney cells transfected with prestin, the outer hair cell motor protein Neuroscience Letters Meltzer J, Santos-Sacchi J 989380800 Journal Article

Education

Academic Appointments

  • 2006–2010: Postdoctoral Fellow, Language Section, National Institute on Deafness and Other Communication Disorders, Bethesda, MD

Research Projects

External

  • 2001–2004: Graduate Research Fellowship
    Institutions: Yale University

    Sponsors: National Science Foundation Fellowship

  • 2005–2006: Graduate Research Fellowship
    Institutions: Yale University

    Sponsors: American Epilepsy Society Fellowship

Internal

  • 2006–2010:
    Supervisor: Allen Braun
    Institutions: National Institute on Deafness and Other Communication Disorders

    Sponsors: NIH Intramural Postdoctoral Fellowship

Contact

3560 Bathurst St.
Toronto, ON M6A 2E1 Phone: 416 785 2500 x2117 Email: jmeltzer@rotman-baycrest.on.ca Fax: 416 785 2862