Research | Baycrest

Chen, Jean Dr.

Jean Chen

Jean Chen

Scientist Rotman Research Institute

Assistant Professor Medical Biophysics, University of Toronto

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Research Focus

  • Functional MRI methodological development
  • Measurement of cerebral perfusion and metabolism using MRI techniques
  • Measurement of tissue microstructure using diffusion-weighted MRI
  • Investigating the relationship between functional and structural brain changes in neurodegenerative diseases

Publications

Title Source (Journal/Book/Conference) Authors/Presenters Published On Type
The Relationship between Cortical Blood Flow and Sub-Cortical White-Matter Health across the Adult Age Span PLoS One Chen JJ, Rosas HD, Salat DH 1361422800 Journal Article
Complex relationships between cerebral blood flow and brain atrophy in early Huntington's disease. NeuroImage Chen JJ, Salat DH, Rosas HD 1325394000 Journal Article
Age-associated reductions in cerebral blood flow are independent from regional atrophy. NeuroImage Chen JJ, Rosas HD, Salat DH 1293858000 Journal Article
Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease. NeuroImage Salat DH, Chen JJ, van der Kouwe AJ, Greve DN, Fischl B, Rosas HD 1293858000 Journal Article
MRI measurement of the BOLD-specific flow-volume relationship during hypercapnia and hypocapnia in humans. NeuroImage Chen JJ, Pike GB 1262322000 Journal Article
Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Chen JJ, Pike GB 1262322000 Journal Article
BOLD-specific cerebral blood volume and blood flow changes during neuronal activation in humans. NMR in biomedicine Chen JJ, Pike GB 1230786000 Journal Article
Origins of the BOLD post-stimulus undershoot. NeuroImage Chen JJ, Pike GB 1230786000 Journal Article
Human whole blood T2 relaxometry at 3 Tesla. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Chen JJ, Pike GB 1230786000 Journal Article
Cerebral blood flow measurement using fMRI and PET: a cross-validation study. International journal of biomedical imaging Chen JJ, Wieckowska M, Meyer E, Pike GB 1199163600 Journal Article
The impact of partial-volume effects in dynamic susceptibility contrast magnetic resonance perfusion imaging. Journal of magnetic resonance imaging : JMRI Chen JJ, Smith MR, Frayne R 1104555600 Journal Article
Reassessing the clinical efficacy of two MR quantitative DSC PWI CBF algorithms following cross-calibration with PET images. Physics in medicine and biology Chen JJ, Frayne R, Smith MR 1104555600 Journal Article
Advantages of frequency-domain modeling in dynamic-susceptibility contrast magnetic resonance cerebral blood flow quantification. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Chen JJ, Smith MR, Frayne R 1104555600 Journal Article
Partial volume effect in quantitative magnetic resonance perfusion imaging. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Chen JJ, Smith MR, Frayne R 1072933200 Journal Article

Education

  • 2011: Postdoctorate, Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital
  • 2009: PhD, Biomedical Engineering, McGill University, Montreal Neurological Institute
  • 2004: MSc, Electrical Engineering, University of Calgary

Academic Appointments

  • 2011–Present: Scientist, Rotman Research Institute
  • 2011–Present: Assistant Professor, Medical Biophysics, University of Toronto

Reviewership

Consulting

  • NeuroImage
  • Magnetic Resonance in Medicine
  • Journal of Cerebral Blood Flow and Metabolism
  • Journal of Magnetic Resonance Imaging
  • PLoS ONE
  • Journal of Gerontology
  • Journal of Pharmacology and Experimental Therapeutics
  • 2010–Present: Neurobiology of Aging

Research Projects

External

  • 2012–2017: Discovery Grant: "Investigating the Neuronal and Vascular Contributions to the Spontaneous BOLD fMRI Signal Fluctuations Underlying Functional Connectivity"

    Sponsors: NSERC

  • 2009–2011: Postdoctoral Fellowship

    Sponsors: CIHR

  • 2013–2017: Operating Grant: "Physiological Basis of Resting-State fMRI"

    Sponsors: CIHR Research Grant

Curriculum Vitae

Contact Us:

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Phone: (416) 785-2500

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