Howard Chertkow

Dr. Howard Chertkow

Chair in Cognitive Neurology and Innovation Director Rotman Research Institute, Baycrest Centre

Director Kimel Centre for Brain Wellness , Baycrest Centre

Clinical Advisor Centre for Aging + Brain Health Innovation, Baycrest Centre

Research Themes: Alzheimer's & Related Dementias, Aging & Brain Health, Cognitive Neuroscience

Research Techniques: Patient-based research, Intervention research, tDCS, MRI

Research Focus

Dr. Howard Chertkow is a remarkably distinguished cognitive neurologist whose contributions are admired across the world. Dr. Chertkow joins Baycrest and the University of Toronto from Montreal’s McGill University, where he served as Director of the Jewish General Hospital (JGH) and McGill University Bloomfield Centre for Research in Aging and was a Senior Investigator in the Lady Davis Institute for Medical Research. In his practice at the JGH, Dr. Chertkow diagnosed and treated patients with early stage Alzheimer’s disease and other dementias, and helped found and direct Canada’s largest memory clinic.
 
Dr. Chertkow will direct the new Kimel Family Centre for Brain Health and Wellness, a research, education and clinical interdisciplinary program to develop and evaluate the most promising approaches to preventing cognitive decline. As its inaugural Director, Dr. Chertkow will assemble a state-of-the-art Clinical Trials Unit and further develop Baycrest’s translational research program in dementia to test the latest emerging therapies for Alzheimer’s disease and related conditions. He will also serve as a Clinical Advisor to the Centre for Aging + Brain Health Innovation (CABHI), the largest venture of its kind in the global seniors’ care sector.
 
He is an exceptionally prolific researcher in the area of dementia, serving since 2014 as Scientific Director of the Canadian Consortium on Neurodegeneration in Aging (CCNA), which has brought together 400 leading dementia researchers in Canada.  Dr. Chertkow is an elected member of the Canadian Academy of Health Sciences.
 
His areas of research interest include: early diagnosis of Alzheimer’s disease and prediction of deterioration in individuals with mild cognitive impairment (MCI); the structure, organization, and function of the semantic memory component of long term memory, and its deterioration in dementia; localization of language and memory functions in the brain using functional imaging; and therapy of cognitive disorders in Alzheimer’s disease and frontotemporal dementia using neuromodulation approaches.

Publications

Title Source (Journal/Book/Conference) Authors/Presenters Published On Type
Subcortical amyloid load is associated with shape and volume in cognitively normal individuals. Human brain mapping Rahayel S, Bocti C, Sévigny Dupont P, Joannette M, Lavallée MM, Nikelski J, Chertkow H, Joubert S 1546318800 Journal Article
Development and validation of a salivary tau biomarker in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands) Pekeles H, Qureshi HY, Paudel HK, Schipper HM, Gornistky M, Chertkow H 1546318800 Journal Article
The Frontotemporal Dementia versus Primary Psychiatric Disorder (FTD versus PPD) Checklist: A Bedside Clinical Tool to Identify Behavioral Variant FTD in Patients with Late-Onset Behavioral Changes. Journal of Alzheimer's disease : JAD Ducharme S, Pearl-Dowler L, Gossink F, McCarthy J, Lai J, Dickerson BC, Chertkow H, Rapin L, Vijverberg E, Krudop W, Dols A, Pijnenburg Y 1546318800 Journal Article
Donepezil for gait and falls in mild cognitive impairment: a randomized controlled trial. European journal of neurology Montero-Odasso M, Speechley M, Chertkow H, Sarquis-Adamson Y, Wells J, Borrie M, Vanderhaeghe L, Zou GY, Fraser S, Bherer L, Muir-Hunter SW 1546318800 Journal Article
National Neuroinformatics Framework for Canadian Consortium on Neurodegeneration in Aging (CCNA). Frontiers in neuroinformatics Mohaddes Z, Das S, Abou-Haidar R, Safi-Harab M, Blader D, Callegaro J, Henri-Bellemare C, Tunteng JF, Evans L, Campbell T, Lo D, Morin PE, Whitehead V, Chertkow H, Evans AC 1514782800 Journal Article
An Action Plan to Face the Challenge of Dementia: INTERNATIONAL STATEMENT ON DEMENTIA from IAP for Health. The journal of prevention of Alzheimer's disease Chertkow H 1514782800 Journal Article
Motor and Cognitive Trajectories Before Dementia: Results from Gait and Brain Study. Journal of the American Geriatrics Society Montero-Odasso M, Speechley M, Muir-Hunter SW, Sarquis-Adamson Y, Sposato LA, Hachinski V, Borrie M, Wells J, Black A, Sejdić E, Bherer L, Chertkow H, 1514782800 Journal Article
Structural brain differences between monolingual and multilingual patients with mild cognitive impairment and Alzheimer disease: Evidence for cognitive reserve. Neuropsychologia Duncan HD, Nikelski J, Pilon R, Steffener J, Chertkow H, Phillips NA 1514782800 Journal Article
Integrating sex and gender into neurodegeneration research: A six-component strategy. Alzheimer's & dementia (New York, N. Y.) Tierney MC, Curtis AF, Chertkow H, Rylett RJ 1483246800 Journal Article
Inferior parietal transcranial direct current stimulation with training improves cognition in anomic Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia (New York, N. Y.) Roncero C, Kniefel H, Service E, Thiel A, Probst S, Chertkow H 1483246800 Journal Article
Application of calibrated fMRI in Alzheimer's disease. NeuroImage. Clinical Lajoie I, Nugent S, Debacker C, Dyson K, Tancredi FB, Badhwar A, Belleville S, Deschaintre Y, Bellec P, Doyon J, Bocti C, Gauthier S, Arnold D, Kergoat MJ, Chertkow H, Monchi O, Hoge RD 1483246800 Journal Article
A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment. Data in brief Tam A, Dansereau C, Badhwar A, Orban P, Belleville S, Chertkow H, Dagher A, Hanganu A, Monchi O, Rosa-Neto P, Shmuel A, Breitner J, Bellec P, 1451624400 Journal Article
Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four Independent Studies. Frontiers in aging neuroscience Tam A, Dansereau C, Badhwar A, Orban P, Belleville S, Chertkow H, Dagher A, Hanganu A, Monchi O, Rosa-Neto P, Shmuel A, Wang S, Breitner J, Bellec P, 1420088400 Journal Article
Patterns of Cognitive Decline Prior to Dementia in Persons with Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD Cloutier S, Chertkow H, Kergoat MJ, Gauthier S, Belleville S 1420088400 Journal Article
Visual selective attention in mild cognitive impairment: Effects of task demands and auditory cues. Journals of Gerontology: Psychological Sciences McLaughlin PM, Anderson ND, Rich JB, Chertkow H, Murtha SJE 1377230400 Journal Article
Diagnosis and treatment of dementia: 5. Nonpharmacologic and pharmacologic therapy for mild to moderate dementia Canadian Medical Association Journal Hogan DB, Bailey P, Black S, Carswell A, Chertkow H, Clarke B, Cohen C, Fisk JD, Forbes D, Man-Son-Hing M, Lanctot K, Morgan D, Thorpe L 1225774800 Journal Article
Diagnosis and treatment of dementia: 4. Approach to management of mild to moderate dementia Canadian Medical Association Journal Hogan DB, Bailey P, Black S, Carswell A, Chertkow H, Clarke B, Cohen C, Fisk JD, Forbes D, Man-Son-Hing M, Lanctot K, Morgan D, Thorpe L 1223352000 Journal Article
Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia Canadian Medical Association Journal Chertkow H, Massoud F, Nasreddine Z, Belleville S, Joanette Y, Bocti C, Drolet V, Kirk J, Freedman M, Bergman H 1210046400 Journal Article
Diagnosis and treatment of dementia: 2. Diagnosis Canadian Medical Association Journal Feldman HH, Jacova C, Robillard A, Garcia A, Chow T, Borrie M, Schipper HM, Blair M, Kertesz A, Chertkow H 1206417600 Journal Article
Mild cognitive impairment and cognitive impairment, no dementia: Part B, therapy Alzheimer's & Dementia Massoud F, Belleville S, Bergman H, Kirk J, Chertkow H, Nasreddine Z, Joanette Y, Freedman M 1191211200 Journal Article
Imaging biomarkers and their role in dementia clinical trials Canadian Journal of Neurological Sciences Chertkow H, Black S 1167627600 Journal Article
Progress in clinical neurosciences: Canadian guidelines for the development of antidementia therapies: a conceptual summary Canadian Journal of Neurological Sciences Feldman HH, Gauthier S, Chertkow H, Conn DK, Freedman M, Chris M, 1136091600 Journal Article
A case study of pure word deafness: modularity in auditory processing? Neurocase Pinard M, Chertkow H, Black S, Peretz I 1009861200 Journal Article

Education

  • 1978: M.D., University of Western Ontario
  • 1985: F.R.C.P, McGill University
  • 1985: Chief Resident, Montreal Neurological Hosptial

Academic Appointments

  • 2018–Present: Chair in Cognitive Neurology and Innovation Director, Rotman Research Institute, Baycrest Centre
  • 2018–Present: Director, Kimel Centre for Brain Wellness , Baycrest Centre
  • 2018–Present: Senior Scientist, Rotman Research Institute, Baycrest Centre
  • 2018–Present: Clinical Advisor, Centre for Aging + Brain Health Innovation, Baycrest Centre
  • 2018–Present: Professor, Neurology, Universty of Toronto
  • 2018–Present: Director, Clinical Trials Unit, Baycrest Centre
  • 2005–2018: Professor, Neurology and Neurosurgery, McGill University
  • 2000–2018: Director, Bloomfield Centre for Research and Aging, Lady Davis Institute for Medical Research, McGill University
  • 2000–2005: Associate Professor with Tenture, Neurology and Neurosurgery, McGill University
  • 1992–2018: Associate Member, Division of Geriatric Medicine, Dept. of Medicine, McGill University
  • 1992–2018: Associate Member, School of Human Communication Disorders, McGill University
  • 1988–1997: Assistant Professor, Neurology and Neurosurgery, McGill University
  • 1988–2018: Cognitive Neurology Project Director, Bloomfield Centre for Research in Aging, Lady Davis Institute, Jewish General Hospital
  • 1988–2018: Membre actif, Laboratoire Theophile-Alajouanine , Centre hospitalier Cote-des-Neiges, Montreal
  • 1988–2018: Assistant Professor, McGill Center for Studies on Aging, McGill University
  • 2009–2018: Director, Jewish General Hospital Memory Clinic, McGill University
  • 1995–1996: Acting Director, Jewish General Hospital Memory Clinic, McGill University
  • 1991–2009: Co-director, Jewish General Hospital Memory Clinic, McGill University
  • 1988–2018: Active Consultant, Department of Neurosciences, Sir Mortimer B. Davis, Jewish General Hospital
  • 1988–1991: Consulting Neurologist, Douglas Hospital Brain Tissue Bank
  • 1986–1988: Consultant Neurologist, St-Anne De Bellevue Veternas Hospital

Professional Affiliations

  • 2019:

Distinctions and Awards

  • 2014: Award for Excellence in Psychosocial or Clinical Research, Jewish General Hospital
  • 2014: Elected to the Canadian Academy of Health Sciences
  • 2014: Principal Investigator, Canadian Consortium for Neurodegeneration in Aging (CCNA), national grant awarded by CHRI to LDI, the largest of its kind ever in Canada
  • 2009: most cited paper in mild cognitive impairment, the Thomson Reuters' Essential Science indicators, The Montreal Cognitive Assessment (MoCA) published in the Journal of American Geriatrics Society, April 2005
  • 2008: Irma M Parhad awarded nationally, Consortium of Canadian Centres for Clinical Cognitive Research for "Excellence in Alzheimer's Disease Research"
  • 2008: Finalist, Canadian Magazine Awards
  • 1985: Penfield Award in Neurology, McGill University

Research Projects

External

  • 2018–2020: Developing tDCS as a therapy for Alzheimer's Disease and Frontotemporal dementia.
    Collaborators: T. Roncero, A. Thiel

    Sponsors: W. Garfield Weston Foundation, 149,325.00 (CAN)

    Research Grant
  • 2016–2021: Broad and deep analyses in neurdegeneration (BRAIN)

    Sponsors: CIHR, 4,750,000.00 (CAN)

    Research Grant
  • 2015–2023: Typical and atypical Alzheimer Disease: salivary tau biomarkers, therapy with neuromoduation

    Sponsors: CIHR, 1,695,052.00 (CAN)

    Research Grant
  • 2014–2019: Canadian Consortium on Neurodegeneration in Aging

    Sponsors: CIHR, 33.5 million/5 years (CAN)

    Research Grant
  • 2014–2015: Development and validation of salivary tau as a biomarker for early Alzheimer's Disease

    Sponsors: W. Garfield Weston Foundation, 149,745.00 (CAN)

    Research Grant
  • 2014–2015: Blood-based diagnostic for mild cognitive impaired victims

    Sponsors: National Institute on Aging (NIH), USA, Small Business Innovation. Research Program, 151,531.00 (USD)

    Research Grant
  • 2019: Comparing the nature and evolution of mild Cogntiive Impairments in individuals with and without parkinson's disease

    Sponsors: CIHR, 753,540.00 (CAN)

    Research Grant
  • 2013–2018: CCNA

    Sponsors: CIHR, 71,606.00 (CAN)

    Research Grant
  • 2013–2014: EOI

    Sponsors: CIHR, 25,000.00 (CAN)

    Research Grant

Contact

The Rotman Research Institute
Baycrest
3560 Bathurst Street, 734
Toronto, Ontario
Canada M6A 2E1 Phone: (416) 785-2500 x3956 Email: hchertkow@research.baycrest.org Fax: (416) 785-2862